Recombinant Human ACSL6 Protein, MYC/DDK-tagged
Cat.No. : | ACSL6-1026H |
Product Overview : | Recombinant human ACSL6 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293. |
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Description : | The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol. |
Molecular Mass : | 80.4 kDa |
Purity : | >50 ug/mL as determined by microplate BCA method |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | ACSL6 acyl-CoA synthetase long-chain family member 6 [ Homo sapiens ] |
Official Symbol : | ACSL6 |
Synonyms : | ACS2; FACL6; LACS 6; LACS2; LACS5 |
Gene ID : | 23305 |
mRNA Refseq : | NM_001009185 |
Protein Refseq : | NP_001009185 |
MIM : | 604443 |
UniProt ID : | Q9UKU0 |
Products Types
◆ Recombinant Protein | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionACSL6 expression has been shown to decrease with age, which may contribute to age-related metabolic dysfunction.
Studies have shown that increased ACSL6 expression in adipose tissue is associated with improved insulin sensitivity and decreased risk of developing type 2 diabetes.
ACSL6 is expressed in a variety of tissues, including adipose tissue, liver, muscle, and heart.
ACSL6 is involved in the uptake and utilization of fatty acids in the brain, which plays a critical role in maintaining brain function.
ACSL6 gene expression is regulated by various transcription factors, including PPARs, SREBP-1c, and LXR.
ACSL6 expression is regulated by AMPK, a key cellular energy sensor that activates ACSL6 transcription in response to low energy status.
The C-terminal domain of ACSL6 is responsible for the catalytic activity of the enzyme, which involves the activation of long-chain fatty acids by attaching them to coenzyme A.
ACSL6 is involved in the synthesis and storage of triacylglycerols in lipid droplets, which plays a critical role in maintaining lipid homeostasis.
ACSL6 is involved in the transport of fatty acids into the mitochondria, which is necessary for mitochondrial energy production.
The AMP-binding domain of ACSL6 binds to AMP, which can activate the enzyme and increase its activity.
Customer Reviews (5)
Write a reviewI'm thrilled with the performance of this recombinant protein. It surpassed my expectations in terms of purity and yield.
I'm amazed at the performance of this recombinant protein. It worked flawlessly in my assays, and the results were reproducible.
The high-quality protein allowed me to achieve robust and reliable results. I'm extremely satisfied with my purchase.
Overall, I highly recommend this recombinant protein and the manufacturer for their excellent product and service.
The recombinant protein was delivered promptly, and the packaging ensured its stability. The purity and activity were excellent, and the product performed consistently.
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