Recombinant Rat ADARB2 Protein, His (Fc)-Avi-tagged

• Cat.No.: ADARB2-168R
• Product Overview: Recombinant Rat ADARB2 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Rat
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Adarb2 adenosine deaminase, RNA-specific, B2 [ Rattus norvegicus ]
• Official Symbol: ADARB2
• Gene ID: 117088
• mRNA Refseq: NM_133302.2
• Protein Refseq: NP_579836.1
• UniProt ID: P97616

Q&As

Are there any FDA-approved drugs that target ADARB2 protein?

There are currently no FDA-approved drugs that target ADARB2 protein. However, preclinical studies are investigating the efficacy of ADARB2 inhibitors in neurological disorders.

Can ADARB2 protein be used in gene therapy approaches?

ADARB2 has been explored as a potential target for gene therapy approaches to treat neurological disorders such as epilepsy. Gene therapy approaches involving ADARB2 would aim to increase or decrease its expression or activity in specific brain regions to modulate neuronal excitability and prevent seizures. However, more research is needed to develop safe and effective gene therapy strategies for neurological disorders.

Can ADARB2 protein be used as a therapeutic target for neurological disorders?

Yes, ADARB2 has been suggested as a potential therapeutic target for neurological disorders such as depression, anxiety, and epilepsy. Its role in regulating neurotransmitter receptor expression and neuronal excitability make it an attractive target for drugs that can modulate its activity.

Can ADARB2 protein be used as a diagnostic biomarker for neurological disorders?

It is possible that ADARB2 expression or activity levels could serve as diagnostic biomarkers for certain neurological disorders. For example, decreased ADARB2 activity has been associated with depression and anxiety, and increased ADARB2 activity has been linked to epilepsy. However, more research is needed to determine the specificity and sensitivity of ADARB2 as a diagnostic biomarker.

Can ADARB2 protein affect immune function?

ADARB2 protein is expressed in various immune cells, including T cells and B cells, where it can affect gene expression and function. Dysregulation of ADARB2 activity has been implicated in autoimmune diseases such as multiple sclerosis and inflammatory bowel disease. Additionally, a recent study found that ADARB2 activity is necessary for optimal antiviral immune responses. These findings suggest that ADARB2 may play a role in regulating immune function.

What are the potential therapeutic applications of ADARB2 protein?

ADARB2 protein has potential therapeutic applications in neurological disorders, specifically epilepsy and mood disorders such as depression and anxiety. ADARB2 inhibitors may increase serotonin and dopamine neurotransmitter levels, improving mood and reducing the incidence of seizures.

Can ADARB2 inhibitors be used in combination with other drugs?

It is possible to use ADARB2 inhibitors in combination with other drugs, but the potential interactions and side effects of such combinations need to be carefully studied.

Is it possible to develop drugs that can selectively target ADARB2 protein?

Yes, researchers have developed compounds that can selectively inhibit or activate ADARB2 activity in experimental settings. These compounds can be used to study the role of ADARB2 in disease pathology and may eventually lead to the development of drugs that can modulate ADARB2 activity for therapeutic purposes.

Is ADARB2 protein involved in regulating circadian rhythms?

Yes, ADARB2 has been identified as a regulator of circadian rhythms, which are the biological processes that govern our sleep-wake cycle and other physiological functions. Studies have found that ADARB2 activity is necessary for normal circadian rhythm function, and its dysregulation can contribute to circadian rhythm disorders like insomnia. This suggests that ADARB2 could be a potential therapeutic target for these conditions.

How is ADARB2 protein related to RNA editing?

ADARB2 protein is one of the enzymes involved in RNA editing, a process that modifies RNA molecules after they are transcribed from DNA. Specifically, ADARB2 catalyzes the conversion of adenosine to inosine in double-stranded RNA molecules. This process can have a significant impact on gene expression and function by altering the genetic code of RNA molecules, and dysregulation of RNA editing has been associated with various diseases.

Are there any drugs that interact with ADARB2 protein?

There are currently no drugs approved for clinical use that directly interact with ADARB2 protein. However, several compounds that inhibit or activate ADARB2 have been investigated in preclinical studies as potential therapies for various diseases, as discussed above.

How do ADARB2 inhibitors work?

ADARB2 inhibitors work by blocking the activity of the ADARB2 protein, which is involved in RNA editing in neurons. By inhibiting ADARB2, these compounds alter the RNA editing patterns, which can affect neurotransmitter levels and potentially improve mood and reduce seizure incidence.

What are the potential side effects of ADARB2 inhibitors?

The potential side effects of ADARB2 inhibitors are not fully understood, but they may include mood changes, such as anxiety and depression, as well as potential disturbances in motor function.

Is ADARB2 protein involved in Alzheimer's disease?

Yes, ADARB2 protein has been implicated in Alzheimer's disease (AD). A study found that ADAR2 protein levels were decreased in the hippocampus, a brain region involved in memory formation, of AD patients compared to healthy individuals. Additionally, decreased ADARB2 activity has been associated with increased levels of amyloid-beta peptide, a hallmark of AD pathology. However, more research is needed to understand the exact role of ADARB2 in AD and whether it could be a therapeutic target for the disease.

Can ADARB2 protein be used as a biomarker for cancer diagnosis?

There is some evidence that ADARB2 protein expression may be a useful biomarker for certain types of cancer. For example, ADARB2 expression is decreased in lung cancer, and low levels of ADARB2 were found to be associated with poor prognosis in patients with liver cancer. However, more studies are needed to determine whether ADARB2 expression can be used as a reliable biomarker for cancer diagnosis.