Recombinant Rat AGRN Protein

• Cat.No.: AGRN-564R
• Product Overview: Recombinant Rat AGRN full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Rat
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Agrn agrin [ Rattus norvegicus ]
• Official Symbol: AGRN
• Gene ID: 25592
• mRNA Refseq: NM_175754.1
• Protein Refseq: NP_786930.1
• UniProt ID: P25304

Reviews

11/23/2022

The packaging was secure, and the proteins maintained their integrity and activity upon arrival.

12/03/2021

I highly recommend their products for researchers seeking reliable reagents.

09/14/2021

They offer excellent value for the price.

07/09/2021

We rely on this protein for its consistent performance.

05/22/2021

I am extremely satisfied with the prompt delivery of the proteins.

Q&As

Can AGRN be used as a diagnostic marker for neurological diseases?

The measurement of AGRN levels or its isoforms in biological fluids or tissues may hold potential as diagnostic markers for certain neurological disorders, although further research is needed.

How is AGRN involved in neuromuscular junction formation?

AGRN interacts with specific receptors on the muscle and nerve cells, initiating a signaling cascade that leads to the clustering of acetylcholine receptors and the formation and maintenance of the NMJ.

Is AGRN involved in other organ systems besides the neuromuscular junction?

Yes, AGRN has been shown to have roles outside of the NMJ, including in the development of the central nervous system, kidneys, and cardiovascular system.

What are the isoforms of AGRN?

AGRN exists in multiple isoforms generated by alternative splicing. The most well-known isoforms include the neural isoforms (Agrin-N) and the muscle-specific isoforms (Agrin-M).

What is the structure of AGRN?

AGRN consists of several functional domains, including N-terminal laminin G-like (LG) domains, central EGF-like repeats, a C-terminal domain, and a heparin-binding site.

How is AGRN involved in cancer progression?

AGRN has been found to promote tumor cell migration, invasion, and metastasis by interacting with receptors and signaling pathways that regulate cell adhesion, migration, and angiogenesis.

How is AGRN expression regulated?

AGRN expression is tightly regulated during development and can be influenced by various signaling pathways, including Wnt, BMP, and Notch signaling.

What are the receptor molecules for AGRN?

AGRN interacts with two major receptors: muscle-specific kinase (MuSK) on the postsynaptic membrane and low-density lipoprotein receptor-related protein 4 (LRP4) on the presynaptic membrane.

How is AGRN involved in synaptic plasticity?

AGRN plays a role in regulating synaptic plasticity by modulating the structure and function of synapses, including their strength and stability.

How is AGRN involved in synaptic maturation?

AGRN regulates the maturation and stabilization of synapses by promoting the clustering of postsynaptic receptors and facilitating the development of pre- and postsynaptic specializations.