Recombinant Rat AJAP1 Protein Pre-coupled Magnetic Beads

• Cat.No.: AJAP1-236R-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Rat
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Ajap1 adherens junction associated protein 1 [ Rattus norvegicus ]
• Official Symbol: AJAP1
• Gene ID: 687031
• mRNA Refseq: NM_001101014.1
• Protein Refseq: NP_001094484.1
• UniProt ID: Q4W8E7

Reviews

03/26/2022

In addition to its esteemed quality, the manufacturer of the AIRE protein offers unparalleled technical support, ready to address any challenges that may arise during my experimental journey.

11/26/2021

Their expert team of professionals possesses an in-depth understanding of the intricacies surrounding the AIRE protein and can provide prompt and effective solutions to any queries or concerns I may encounter.

03/29/2018

With its exceptional purity and consistency, this protein surpasses all expectations, ensuring reliable and conclusive outcomes for my research endeavors.

Q&As

Can AJAP1 interact with other proteins?

Yes, AJAP1 has been shown to interact with other proteins. For instance, it has been found to interact with α-catenin, a vital component of adherens junctions, to regulate cell-cell adhesion. AJAP1 has also been reported to interact with PDZ domain-containing proteins, such as ZO-2 and MAGI-1, which are involved in cell signaling and junctional complex assembly.

How is AJAP1 involved in cell migration?

AJAP1 plays a role in regulating cell migration through its interaction with signaling molecules and the cytoskeleton. It can modulate the activity of Rho GTPases, key regulators of cell migration, and influence actin dynamics, which are essential for cell movement. AJAP1 also interacts with components of focal adhesions, structures involved in cell anchoring and motility, suggesting its involvement in cell migration processes.

Where is the AJAP1 protein expressed in the body?

AJAP1 is expressed in various tissues throughout the body. It is found in epithelial tissues, such as the lining of the intestine and skin, as well as in other tissues like the brain and heart.

Are there any known binding partners or interacting proteins for AJAP1?

Yes, AJAP1 has been shown to interact with several proteins involved in cell adhesion and signaling processes. For example, it can bind to β-catenin and E-cadherin, which are key components of adherens junctions. AJAP1 also interacts with cytoskeletal elements such as actin and microtubules, as well as signaling molecules such as Src kinase.

Can AJAP1 be used as a diagnostic or prognostic marker for cancer?

AJAP1 has shown promise as a potential diagnostic and prognostic marker in cancer. Its downregulation or loss of expression has been correlated with worse prognosis and increased tumor metastasis in various types of cancer, including colorectal, lung, and breast cancer. Further research is needed to validate its clinical utility as a biomarker and to determine its potential as a therapeutic target.

Are there any known genetic mutations in the AJAP1 gene?

Currently, there is limited information available about genetic mutations specifically in the AJAP1 gene. However, mutations in genes related to adherens junctions and cell adhesion molecules have been associated with certain diseases and conditions, such as cancer metastasis and developmental disorders.

Are there any known therapeutic approaches targeting AJAP1?

Currently, there are no specific therapeutic approaches targeting AJAP1. However, the emerging understanding of its role in cancer and other diseases could lead to the development of novel therapies in the future. For example, strategies that enhance AJAP1 expression or stabilize its interactions with other proteins could be explored to potentially inhibit tumor progression and metastasis.

What are the potential roles of AJAP1 in disease?

The exact role of AJAP1 in disease is still being investigated. However, studies have suggested that AJAP1 may be involved in various biological processes relevant to disease, including tumor suppression, angiogenesis (formation of new blood vessels), and neuronal development. Further research is needed to fully understand the implications of AJAP1 in different disease contexts.

Are there any current research studies or clinical trials focused on the AJAP1 protein?

Currently, there is limited information on specific research studies or clinical trials focused solely on the AJAP1 protein. However, ongoing research in the fields of cell adhesion, cancer biology, and developmental biology may explore the role of AJAP1 in various disease processes. Stay updated with scientific literature and clinical trial databases for the latest information on studies related to AJAP1.

Does AJAP1 have any genetic variations or mutations associated with diseases?

While AJAP1 mutations have not been extensively studied, some studies have reported genetic variations in AJAP1 that may be associated with certain diseases. For example, single nucleotide polymorphisms (SNPs) in the AJAP1 gene have been linked to schizophrenia susceptibility in some populations. However, more research is needed to fully understand the impact of AJAP1 genetic variations on disease development and progression.

How is the AJAP1 protein regulated?

The regulation of AJAP1 protein expression and function is still not fully understood. However, studies have indicated that AJAP1 expression can be regulated at the transcriptional level by various signaling pathways and transcription factors. Additionally, post-translational modifications, such as phosphorylation and ubiquitination, may also influence the activity and stability of AJAP1 protein.

Can AJAP1 be targeted for therapeutic purposes?

Targeting AJAP1 for therapeutic purposes is currently not well explored. However, as AJAP1 is involved in cell adhesion and regulation of various cellular processes, it is possible that it could be a target for future therapeutic interventions. Further research is needed to better understand the specific mechanisms and functions of AJAP1 in disease contexts in order to evaluate its potential as a therapeutic target.

Is AJAP1 associated with any diseases?

AJAP1 has been implicated in various diseases and conditions. Alterations in AJAP1 expression or function have been observed in certain types of cancer, including breast, colorectal, and gastric cancer, suggesting a potential role in tumor progression and metastasis. AJAP1 has also been linked to neurological disorders, such as epilepsy and Alzheimer's disease, in which abnormalities in cell adhesion and synapse formation are present. However, more research is needed to fully understand the involvement of AJAP1 in these diseases.