AJAP1
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Official Full Name
adherens junctions associated protein 1
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Synonyms
AJAP1;adherens junctions associated protein 1;30801;ENSG00000196581;MOT8;SHREW1;SHREW-1;RP3-426F10.1;1p36.32;adherens junction-associated protein 1;adherens junction-associated protein 1;membrane protein shrew-1;transmembrane protein SHREW1;adherens junction associated protein 1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- E.coli expression system
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AJAP1-482H | Recombinant Human AJAP1 Protein | Wheat Germ | N/A | ||
Human | AJAP1-961HF | Recombinant Full Length Human AJAP1 Protein | In Vitro Cell Free System | 411 amino acids | ||
Mouse | Ajap1-3195M | Recombinant Mouse Ajap1, His-tagged | E.Coli or Yeast | His | 412 | |
Mouse | AJAP1-1461M | Recombinant Mouse AJAP1 Protein | Mammalian Cell | His | ||
Mouse | AJAP1-419M | Recombinant Mouse AJAP1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | AJAP1-419M-B | Recombinant Mouse AJAP1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | AJAP1-580R | Recombinant Rat AJAP1 Protein | Mammalian Cell | His | ||
Rat | AJAP1-236R | Recombinant Rat AJAP1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | AJAP1-236R-B | Recombinant Rat AJAP1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mus musculus (Mouse) | RFL-10945MF | Recombinant Full Length Mouse Adherens Junction-Associated Protein 1(Ajap1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-412) |
- Involved Pathway
- Protein Function
- Interacting Protein
- AJAP1 Related Articles
AJAP1 involved in several pathways and played different roles in them. We selected most pathways AJAP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AJAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AJAP1 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by AJAP1 itself. We selected most functions AJAP1 had, and list some proteins which have the same functions with AJAP1. You can find most of the proteins on our site.
Function | Related Protein |
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molecular_function | INPP4AA;TMEM194B;MUP12;HHLA1;MINOS1;LPIN1;GHDC;ARXES2;HSPA7 |
AJAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AJAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AJAP1.
- Q&As
- Reviews
Q&As (13)
Ask a questionYes, AJAP1 has been shown to interact with other proteins. For instance, it has been found to interact with α-catenin, a vital component of adherens junctions, to regulate cell-cell adhesion. AJAP1 has also been reported to interact with PDZ domain-containing proteins, such as ZO-2 and MAGI-1, which are involved in cell signaling and junctional complex assembly.
AJAP1 plays a role in regulating cell migration through its interaction with signaling molecules and the cytoskeleton. It can modulate the activity of Rho GTPases, key regulators of cell migration, and influence actin dynamics, which are essential for cell movement. AJAP1 also interacts with components of focal adhesions, structures involved in cell anchoring and motility, suggesting its involvement in cell migration processes.
AJAP1 is expressed in various tissues throughout the body. It is found in epithelial tissues, such as the lining of the intestine and skin, as well as in other tissues like the brain and heart.
Yes, AJAP1 has been shown to interact with several proteins involved in cell adhesion and signaling processes. For example, it can bind to β-catenin and E-cadherin, which are key components of adherens junctions. AJAP1 also interacts with cytoskeletal elements such as actin and microtubules, as well as signaling molecules such as Src kinase.
AJAP1 has shown promise as a potential diagnostic and prognostic marker in cancer. Its downregulation or loss of expression has been correlated with worse prognosis and increased tumor metastasis in various types of cancer, including colorectal, lung, and breast cancer. Further research is needed to validate its clinical utility as a biomarker and to determine its potential as a therapeutic target.
Currently, there is limited information available about genetic mutations specifically in the AJAP1 gene. However, mutations in genes related to adherens junctions and cell adhesion molecules have been associated with certain diseases and conditions, such as cancer metastasis and developmental disorders.
Currently, there are no specific therapeutic approaches targeting AJAP1. However, the emerging understanding of its role in cancer and other diseases could lead to the development of novel therapies in the future. For example, strategies that enhance AJAP1 expression or stabilize its interactions with other proteins could be explored to potentially inhibit tumor progression and metastasis.
The exact role of AJAP1 in disease is still being investigated. However, studies have suggested that AJAP1 may be involved in various biological processes relevant to disease, including tumor suppression, angiogenesis (formation of new blood vessels), and neuronal development. Further research is needed to fully understand the implications of AJAP1 in different disease contexts.
Currently, there is limited information on specific research studies or clinical trials focused solely on the AJAP1 protein. However, ongoing research in the fields of cell adhesion, cancer biology, and developmental biology may explore the role of AJAP1 in various disease processes. Stay updated with scientific literature and clinical trial databases for the latest information on studies related to AJAP1.
While AJAP1 mutations have not been extensively studied, some studies have reported genetic variations in AJAP1 that may be associated with certain diseases. For example, single nucleotide polymorphisms (SNPs) in the AJAP1 gene have been linked to schizophrenia susceptibility in some populations. However, more research is needed to fully understand the impact of AJAP1 genetic variations on disease development and progression.
The regulation of AJAP1 protein expression and function is still not fully understood. However, studies have indicated that AJAP1 expression can be regulated at the transcriptional level by various signaling pathways and transcription factors. Additionally, post-translational modifications, such as phosphorylation and ubiquitination, may also influence the activity and stability of AJAP1 protein.
Targeting AJAP1 for therapeutic purposes is currently not well explored. However, as AJAP1 is involved in cell adhesion and regulation of various cellular processes, it is possible that it could be a target for future therapeutic interventions. Further research is needed to better understand the specific mechanisms and functions of AJAP1 in disease contexts in order to evaluate its potential as a therapeutic target.
AJAP1 has been implicated in various diseases and conditions. Alterations in AJAP1 expression or function have been observed in certain types of cancer, including breast, colorectal, and gastric cancer, suggesting a potential role in tumor progression and metastasis. AJAP1 has also been linked to neurological disorders, such as epilepsy and Alzheimer's disease, in which abnormalities in cell adhesion and synapse formation are present. However, more research is needed to fully understand the involvement of AJAP1 in these diseases.
Customer Reviews (3)
Write a reviewIn addition to its esteemed quality, the manufacturer of the AIRE protein offers unparalleled technical support, ready to address any challenges that may arise during my experimental journey.
Their expert team of professionals possesses an in-depth understanding of the intricacies surrounding the AIRE protein and can provide prompt and effective solutions to any queries or concerns I may encounter.
With its exceptional purity and consistency, this protein surpasses all expectations, ensuring reliable and conclusive outcomes for my research endeavors.
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