Recombinant Rat ALS2 Protein Pre-coupled Magnetic Beads

• Cat.No.: ALS2-298R-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Rat
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Als2 amyotrophic lateral sclerosis 2 (juvenile) [ Rattus norvegicus ]
• Official Symbol: ALS2
• Gene ID: 363235
• mRNA Refseq: NM_001013413.1
• Protein Refseq: NP_001013431.1
• UniProt ID: P0C5Y8

Reviews

11/13/2017

Robust antibody for immunoprecipitation experiments.

07/21/2017

Excellent signal-to-noise ratio in assays.

01/21/2017

Accurate determination of protein-protein interaction kinetics.

Q&As

What are the functional domains and motifs within ALS2, and how do they contribute to its enzymatic activities or protein-protein interactions?

ALS2 contains functional domains, including RhoGAP and VPS9 domains, which contribute to its GTPase activity, protein interactions, or membrane association.

What is the role of ALS2 in axonal growth, neuronal development, or cytoskeletal organization?

ALS2 plays a role in regulating axonal growth, neurite outgrowth, or cytoskeletal organization, potentially influencing neuronal development and connectivity.

What are the subcellular localization patterns of ALS2 and its association with cellular compartments or organelles?

ALS2 exhibits a predominantly cytoplasmic localization, with possible associations with endosomes, the Golgi apparatus, or cytoskeletal structures.

How does ALS2 contribute to motor neuron degeneration in the context of amyotrophic lateral sclerosis (ALS)?

Dysregulation or mutations in ALS2 can contribute to motor neuron degeneration in ALS, a progressive neurodegenerative disorder characterized by the selective loss of motor neurons in the brain and spinal cord.

How does ALS2 expression vary across different tissues and cell types, and what factors regulate its expression levels?

ALS2 expression levels can vary among different tissues and cell types, and they are regulated by factors such as developmental cues, cellular stress, or specific signaling pathways.

Can genetic variations or mutations in ALS2 lead to alterations in ALS2 function or expression, and how do they relate to the pathogenesis of ALS or other neurodegenerative diseases?

Genetic variations or mutations in ALS2 have been associated with juvenile forms of ALS and hereditary spastic paraplegia, suggesting their impact on ALS2 function and disease pathogenesis.

How does ALS2 interact with other proteins and form complexes involved in cellular processes or signaling pathways?

ALS2 interacts with various proteins involved in vesicle trafficking, cytoskeletal dynamics, or signaling cascades, forming complexes critical for its functional roles.

What are the post-translational modifications that regulate ALS2 activity, stability, or subcellular localization?

Post-translational modifications, such as phosphorylation or acetylation, can regulate ALS2 function, stability, or interactions with other proteins.

Can therapeutic interventions targeting ALS2 or its associated pathways provide potential strategies for treating ALS or related motor neuron disorders?

Targeting ALS2 or its associated pathways may offer potential therapeutic strategies for ALS and related motor neuron disorders, aiming to restore neuronal connectivity, enhance vesicle trafficking, or alleviate cellular stress in affected motor neurons.

What are the downstream signaling pathways or cellular processes modulated by ALS2, and how do they impact neuronal function or cellular homeostasis?

ALS2 modulates signaling pathways, such as the Rho GTPase signaling pathway, which are involved in cytoskeletal dynamics, vesicle transport, or cellular responses to extracellular signals.