Recombinant Rat ALS2CR8 Protein, His (Fc)-Avi-tagged

• Cat.No.: ALS2CR8-300R
• Product Overview: Recombinant Rat ALS2CR8 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Rat
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Als2cr8 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8 [ Rattus norvegicus ]
• Official Symbol: ALS2CR8
• Gene ID: 301446
• mRNA Refseq: NM_001106915.1
• Protein Refseq: NP_001100385.1
• UniProt ID: D4A7U2

Reviews

10/25/2022

Compatible with automated liquid handling systems.

08/14/2021

Accurate assessment of protein expression changes.

03/06/2017

Low interference from endogenous proteins in samples.

Q&As

Can the enzymatic activities of ALS2CR8 be characterized, and what are its potential substrates or targets?

The enzymatic activities of ALS2CR8 are not well-characterized, and further studies are needed to identify its potential substrates or targets.

Are there any specific post-translational modifications that regulate ALS2CR8's activity or localization? How do these modifications impact its cellular functions?

ALS2CR8 undergoes specific post-translational modifications, including phosphorylation or ubiquitination, that regulate its activity, stability, or subcellular localization.

Does ALS2CR8 play a role in synaptic function, neuronal connectivity, or plasticity? How does it affect these processes?

ALS2CR8 plays a role in synaptic function, affecting processes such as neurotransmitter release, postsynaptic receptor trafficking, or synaptic vesicle dynamics.

Can therapeutic interventions targeting ALS2CR8 or its associated pathways offer potential strategies for treating neurological disorders or related conditions?

Targeting ALS2CR8 or its associated pathways may hold therapeutic potential for treating neurological disorders, aiming to modulate synaptic function, promote neuronal survival, or enhance neuronal connectivity.

Is ALS2CR8 involved in intracellular signaling pathways or regulation of gene expression? If so, what are the downstream targets or effectors?

ALS2CR8 is implicated in intracellular signaling pathways, such as those involved in neuronal survival, synaptic plasticity, or gene expression regulation.

How does ALS2CR8 expression change during neuronal development or in response to neuronal activity? Are there any factors or conditions that regulate its expression levels?

ALS2CR8 expression is dynamically regulated during neuronal development and can be influenced by factors such as neuronal activity, neurotrophic factors, or signaling molecules.

How does ALS2CR8 contribute to neuronal development and function, and what are the underlying molecular mechanisms?

ALS2CR8 is crucial for neuronal development and function, potentially influencing processes such as neurite outgrowth, synaptogenesis, or synaptic transmission through various molecular mechanisms.

Can the interactions of ALS2CR8 with other proteins or molecular complexes be identified and characterized?

ALS2CR8 interacts with specific proteins or molecular complexes involved in neuronal signaling, cytoskeletal organization, or intracellular transport, which contribute to its cellular functions.

What is the cellular localization of ALS2CR8, and does it exhibit any specific associations with cellular compartments or organelles?

ALS2CR8 is primarily localized to the cytoplasm, with potential associations with specific cellular compartments involved in neuronal function.

What are the functional domains or motifs present in ALS2CR8, and how do they contribute to its cellular functions?

ALS2CR8 contains functional domains and motifs, such as protein-protein interaction domains or enzymatic domains, that play a role in its molecular functions.