Recombinant Rat Ctla4 Protein, hFc-tagged, Alexa Fluor 647 conjugated
Cat.No. : | Ctla4-1143RAF647 |
Product Overview : | Alexa Fluor 647 conjugated recombinant Rat Ctla4 (Ile38-Asp161) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
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Description : | CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis. |
Source : | HEK293 |
Species : | Rat |
Tag : | hFc |
Form : | Lyophilized |
Molecular Mass : | The protein has a calculated MW of 40.2 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE). |
Protein length : | Ile38-Asp161 |
N-terminal Sequence Analysis : | Ile 38 |
Endotoxin : | < 1.0 EU/ μg by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 647 via amines Excitation = 650 nm Emission = 668 nm |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | Ctla4 |
Official Symbol : | Ctla4 |
Synonyms : | CTLA4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte protein 4; soluble form; CD152 antigen; transmembrane form; Cd152; CTLA-4; sCTLA4 |
Gene ID : | 63835 |
mRNA Refseq : | NM_031674 |
Protein Refseq : | NP_113862 |
UniProt ID : | Q62859 |
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◆ Lysates | ||
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◆ Assay kits | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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