Recombinant Rat Ctsb Protein, His-tagged

• Cat.No.: Ctsb-1121R
• Product Overview: Recombinant rat Ctsb (NP_072119.2) (Met1-Phe339) was expressed with a polyhistidine tag at the C-terminus.

Specification

• Source: HEK293
• Species: Rat
• Tag: His
• Predicted N Terminal: His 18
• Form: Lyophilized from sterile 25 mM Tris, 150 mM NaCl, pH 7.5, 5%~8% trehalose and mannitol.
• Molecular Mass: The recombinant rat Ctsb consists 333 amino acids and predicts a molecular mass of 37.1 kDa.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >95 % as determined by SDS-PAGE.
• Stability: Samples are stable for up to twelve months from date of receipt at -70ºC.
• Storage: Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: Ctsb cathepsin B [ Rattus norvegicus ]
• Official Symbol: Ctsb
• Synonyms: CTSB; cathepsin B; RSG-2; cathepsin B1
• Gene ID: 64529
• mRNA Refseq: NM_022597
• Protein Refseq: NP_072119
• Pathway: Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem
• Function: cysteine-type endopeptidase activity; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; endopeptidase activity; kininogen binding; peptidase activity; peptidase activity

Reviews

08/08/2021

Exceptional protein engineering services, our trusted research partner.

07/13/2021

Reliable protein crystallography, key for our structural biology research.

11/15/2018

Swift protein quantification, improves data reliability in our work.

Q&As

How does CTSB affect extracellular matrix remodeling in conditions like osteoarthritis?

CTSB affects extracellular matrix remodeling, relevant in joint diseases like osteoarthritis.

What role does CTSB play in the pathology of neurodegenerative diseases, such as Alzheimer's?

CTSB is implicated in neurodegenerative diseases, potentially contributing to protein aggregation and neuronal damage.

How do alterations in CTSB expression or activity affect tissue repair and fibrosis?

Variations in CTSB expression impact tissue repair processes and the development of fibrosis in various organs.

What are the mechanisms by which CTSB modulates apoptosis and cell survival?

CTSB regulates apoptosis and cell survival, influencing cell fate decisions under stress or damage.

How does CTSB influence the tumor microenvironment and cancer progression?

CTSB can influence cancer progression by modulating the tumor microenvironment and facilitating tumor cell invasion.

How does CTSB (Cathepsin B) contribute to protein degradation and lysosomal function?

CTSB is involved in lysosomal protein degradation, essential for cellular waste disposal and recycling.

What is the impact of CTSB in inflammatory responses and immune cell activation?

CTSB plays a role in inflammation, impacting immune cell function and inflammatory responses.