Recombinant Rat DHODH Protein

• Cat.No.: DHODH-10R
• Product Overview: Recombinant Rat DHODH Protein was expressed in E. coli.

Specification

• Description: Enables FMN binding activity; dihydroorotate dehydrogenase activity; and ubiquinone binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; lactation; and response to L-arginine. Located in mitochondrial inner membrane and neuronal cell body. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)).
• Source: E. coli
• Species: Rat
• Form: Liquid. In 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
• Molecular Mass: ~40 kDa
• AA Sequence: TGDDHFYAEYLMPGLQRLLDPESAH RLAVRVTSLGLLPRATFQDSDMLEV KVLGHKFRNPVGIAAGFDKNGEAVD GLYKLGFGFVEVGSVTPQPQEGNPR PRVFRLPEDQAVINRYGFNSHGLSV VEHRLRARQQKQAQLTADGLPLGIN LGKNKTSEDAAADYAEGVRTLGPLA DYLVVNVSSPNTAGLRSLQGKTELR HLLSKVLQERDALKGTRKPAVLVKI APDLTAQDKEDIASVARELGIDGLI VTNTTVSRPVGLQGALRSETGGLSG KPLRDLSTQTIREMYALTQGRIPII GVGGVSSGQDALEKIQAGASLVQLY TALIFLGPPVVVRVKRELEALLKER GFTTVTDAIGADHRR
• Purity: >90%
• Storage: Short Term Storage at 4 centigrade, Long Term, please prepare aliquots with 20% glycerol and store at -20 to -80 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.1 mg/ml
• Official Full Name: Dihydroorotate dehydrogenase

Gene Information

• Gene Name: Dhodh dihydroorotate dehydrogenase (quinone) [ Rattus norvegicus (Norway rat) ]
• Official Symbol: DHODH
• Synonyms: AI834883; 2810417D19Rik
• Gene ID: 65156
• mRNA Refseq: NM_001008553
• Protein Refseq: NP_001008553
• UniProt ID: Q63707

Reviews

07/29/2020

Saves time and effort. Highly recommended for research.

11/03/2017

Top-notch support for insights. Trusted for accurate data.

05/05/2017

Reliable data, essential for our protein research.

Q&As

How does DHODH contribute to pyrimidine biosynthesis?

It catalyzes a key step in the pyrimidine biosynthesis pathway, converting dihydroorotate to orotate.

What is the primary role of DHODH in cellular metabolism?

DHODH, dihydroorotate dehydrogenase, is crucial for the de novo synthesis of pyrimidines, essential for DNA and RNA synthesis.

How does DHODH interact with other enzymes in the pyrimidine biosynthesis pathway?

DHODH collaborates with other enzymes in pyrimidine biosynthesis, playing a role in nucleotide metabolism.

What role does DHODH play in cell proliferation and growth?

DHODH is important for cell proliferation, as pyrimidine synthesis is essential for DNA replication and cell growth.

How do genetic variations in DHODH affect its function in nucleotide synthesis?

Genetic mutations in DHODH can disrupt nucleotide synthesis, affecting cellular replication and function.

What is the impact of altered DHODH activity on autoimmune diseases?

Altered DHODH activity is linked with autoimmune conditions, as it affects lymphocyte proliferation and function.

What potential therapeutic applications arise from targeting DHODH in disease treatment?

Targeting DHODH in therapies could be effective in treating autoimmune diseases and certain cancers by modulating pyrimidine synthesis.