Recombinant Rat Il22ra1 protein, His & T7-tagged

• Cat.No.: Il22ra1-1322R
• Product Overview: Recombinant Rat Il22ra1 aa. (Leu242~Pro485 (Accession# D3ZIM3) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Rat
• Tag: His & T7
• Form: Freeze-dried powder
• Molecular Mass: 33kDa as determined by SDS-PAGE reducing conditions.
• Protein length: Leu242~Pro485 (Accession# D3ZIM3)
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >90%
• Characteristic: The isoelectric point is 5.2.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: Il22ra1 interleukin 22 receptor subunit alpha 1 [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Il22ra1
• Synonyms: Il22ra1; interleukin 22 receptor subunit alpha 1; RGD1559655; interleukin-22 receptor subunit alpha-1; interleukin 22 receptor, alpha 1
• Gene ID: 362629
• mRNA Refseq: NM_001191869.1
• Protein Refseq: NP_001178798.1
• UniProt ID: D3ZIM3

Reviews

12/18/2022

High stability in serum.

09/04/2017

Suitable for receptor binding.

10/16/2016

Effective in autoimmune studies.

Q&As

What post-translational modifications occur on IL22RA1?

IL22RA1 undergoes phosphorylation.

How does IL22RA1 contribute to IL22 signaling?

IL22RA1 enhances IL22 signaling by forming a complex with IL-10R2.

What impact do IL22RA1 polymorphisms have on disease susceptibility?

IL22RA1 polymorphisms affect disease susceptibility in Crohn's disease.

Is IL22RA1 involved in anti-tumor immunity?

IL22RA1 is involved in anti-tumor immunity by activating STAT3.

How does IL22RA1 expression change in autoimmune diseases?

IL22RA1 expression is upregulated in autoimmune diseases like psoriasis.

How does IL22RA1 contribute to epithelial barrier function?

IL22RA1 enhances epithelial barrier function.

Is IL22RA1 expression tissue-specific?

IL22RA1 expression is tissue-specific, being high in the liver and skin.

Does IL22RA1 interact with other receptors?

IL22RA1 interacts with IL-10R2 and IL-20RB.

What is the affinity of IL22 for IL22RA1?

IL22 has high affinity for IL22RA1.

Does IL22RA1 have alternative splicing variants?

IL22RA1 has multiple alternative splicing variants.