Recombinant Rat Interleukin 15
Cat.No. : | Il15-231R |
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Cat. No. : | Il15-231R |
Description : | Interleukin 15 (IL-15) is a novel cytokine that uses beta- and gamma-chain of IL-2R for signal transduction and is structurally similarity to IL-2. IL-15 is secreted by activated monocytes/macrophages following infection by virus. This cytokine induces cell proliferation of natural killer cells. This cytokine and interleukin 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other"s activity. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. IL-15 can recruit and activate T lymphocytes in the synovial membrane, thereby contributing to Rheumatoid arthritis pathogenesis. |
Source : | Sf 21 Insect Cells. |
Molecular Weight : | The predicted molecular weight of Recombinant Rat IL-15 is Mr 70 kDa. |
State Of Matter : | Lyophilized. |
Purity : | >95% by SDS Page and HPLC. |
Endotoxin : | <1.0 EU/µg. |
Storage And Stability : | The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Gene Name : | Il15 interleukin 15 [ Rattus norvegicus ] |
Synonyms : | Il15; interleukin 15 |
Gene ID : | 25670 |
mRNA Refseq : | NM_013129 |
Protein Refseq : | NP_037261 |
UniProt ID : | P97604 |
Chromosome Location : | 19q11 |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway |
Function : | cytokine activity; molecular_function; protein binding |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionTechniques discern IL15 and IL2 receptor binding kinetics.
Methods explore IL15's role in autoimmune disease mechanisms.
IL15 knockout models provide insights into its diverse functions.
IL15's influence on memory T cell differentiation investigated.
Immunofluorescence microscopy visualizes IL15 subcellular localization.
Approaches validate IL15's involvement in inflammatory responses.
IL15's role in NK cell cytotoxicity analyzed using assays.
ELISA measures IL15 secretion accurately.
qPCR quantifies IL15's impact on regulatory T cells.
Flow cytometry quantifies IL15-driven T-cell proliferation.
Customer Reviews (3)
Write a reviewMapping protein- interactions in DNA transcription for gene regulation.
Suitable for cytotoxicity assays.
Effective in NK cell activation.
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