Recombinant Rhesus Macaque CACUL1 Protein, His (Fc)-Avi-tagged

• Cat.No.: CACUL1-433R
• Product Overview: Recombinant Rhesus Macaque CACUL1 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Rhesus Macaque
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: CACUL1 CDK2-associated, cullin domain 1 [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: CACUL1
• Synonyms: CACUL1; C10orf46; C9H10orf46; CDK2-associated and cullin domain-containing protein 1
• Gene ID: 702200
• mRNA Refseq: NM_001266943
• Protein Refseq: NP_001253872
• UniProt ID: F7GNK2

Reviews

05/12/2022

Product exceeded my expectations!

02/04/2019

Easy to use and effective.

11/28/2018

Great value for the price.

Q&As

How does CACUL1's function relate to its localization within the cell?

CACUL1's subcellular localization varies throughout the cell cycle. It shuttles between the nucleus and cytoplasm, and this dynamic localization is essential for its role in cell cycle regulation and DNA damage response.

How does CACUL1 influence cell cycle progression?

CACUL1 promotes cell cycle progression by forming complexes with CDKs and Cyclins, facilitating their activation. This leads to the phosphorylation of target proteins that drive the cell cycle forward.

What are the key protein-protein interactions involving CACUL1?

CACUL1 interacts with several key cell cycle regulators, including Cyclin-Dependent Kinases (CDKs) and Cyclins. It also interacts with proteins involved in DNA damage repair and checkpoint control.

Can you discuss the role of CACUL1 in epigenetic regulation and chromatin remodeling, and how it impacts gene expression in cancer cells?

Emerging research suggests that CACUL1 is involved in epigenetic regulation by influencing chromatin remodeling processes. It can interact with histone modifiers and transcription factors, leading to changes in gene expression profiles in cancer cells. Understanding these epigenetic mechanisms is vital for targeted cancer therapies.

How is the expression of CACUL1 regulated in normal and cancerous cells?

CACUL1 expression is tightly regulated at the transcriptional level. It is upregulated in many cancer types due to aberrant transcriptional activation, which can be driven by various oncogenic pathways.