Recombinant Rhesus macaque IL13RA2 protein, His-tagged

• Cat.No.: IL13RA2-540R
• Product Overview: Rhesus macaque IL-13 R alpha 2, His Tag is expressed from human 293 cells (HEK293). It contains AA Ser 26 - Ther 340 (Accession # XP_014983540.1).

Specification

• Description: Interleukin-13 receptor subunit alpha-2 is also known as IL13Rα2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL-13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL13Rα2 is closely related to IL13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13. IL13Rα2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 antagonist compared with IL13Rα1. It also functions as an inhibitor of IL4-dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13Rα2 and the IL4Rα chain. In spite of the failed STAT signaling function, IL13Rα2 dose induce TGF-beta production and fibrosis. Additionally, IL13Rα2has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme.
• Source: HEK293
• Species: Rhesus macaque
• Tag: His
• Predicted N Terminal: Ser 26
• Form: Please contact us for detailed information.
• Molecular Mass: The protein has a calculated MW of 40.0 kDa.
• Protein length: Ser 26 - Ther 340
• Storage: For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20°C to -70°C for 12 months in lyophilized state;
  -70°C for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: IL13RA2 interleukin 13 receptor subunit alpha 2 [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: IL13RA2
• Synonyms: IL13RA2; CD213A2; CT19; IL-13R; IL13BP
• Gene ID: 708339
• mRNA Refseq: XM_015128054.2
• Protein Refseq: XP_014983540.1
• UniProt ID: F6Z890

Reviews

07/14/2019

Reliable in co-immunoprecipitation.

09/24/2018

High specificity.

01/05/2017

Effective in asthma models.

Q&As

What experimental methods determine IL13RA2's role in cancer metastasis?

Methods unveil IL13RA2's role in cancer metastasis.

How does proximity ligation assay reveal IL13RA2 interactions with other proteins?

Proximity ligation assay exposes IL13RA2 interactions with proteins.

Can you elaborate on the use of immunohistochemistry in studying IL13RA2 expression in tissues?

Immunohistochemistry maps IL13RA2 expression in tissues.

How do structural studies such as X-ray crystallography inform IL13RA2's ligand binding mechanism?

Structural studies like X-ray crystallography illuminate IL13RA2's ligand binding mechanism.

What are the advantages of using siRNA libraries to explore IL13RA2 functions?

siRNA libraries probe diverse IL13RA2 functions advantageously.

Could you describe how CRISPR screening identifies regulators of IL13RA2 expression?

CRISPR screening identifies regulators of IL13RA2 expression.

What techniques investigate IL13RA2 dimerization in cellular contexts?

Techniques reveal IL13RA2 dimerization in cellular settings.

Could you explain how mass spectrometry identifies IL13RA2 post-translational modifications?

Mass spectrometry detects IL13RA2 post-translational modifications.

How does surface plasmon resonance (SPR) analyze IL13RA2 binding affinities?

SPR quantifies IL13RA2 binding affinities with precision.

How do reporter gene assays assess IL13RA2-mediated signaling pathways?

Reporter gene assays illuminate IL13RA2-mediated signaling.