Recombinant Rhesus Monkey ADGRE2 Protein, 19-530aa, C-His tagged

• Cat.No.: ADGRE2-1722R
• Product Overview: Recombinant Rhesus Monkey ADGRE2 Protein (19-530aa) with C-His tag was expressed in HEK293.

Specification

• Description: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins.
• Source: HEK293
• Species: Rhesus Monkey
• Tag: C-His
• Protein length: 19-530aa
• Molecular Mass: The protein has a calculated MW of 57 kDa.
• AA Sequence: ETQDSRDCARWCPENSSCVNATACR CNPGFSSSSEIFTSPTEICDDINEC VPPSKVSCGKSSDCRNTEGSYDCVC NPGYELVSGAKTFKNESENTCQDVD ECQQNPRLCKSYGTCVNTLGSFTCQ CLPGFKFKPEDPKLCTDVNECTSGQ NPCHSSTHCLNNVGSYQCRCRPGWQ PIPGSPNGPNNTICEDVDECSSGLH QCDNSTVCFNTVGSYTCRCRPGWEP KHGIPNNQKDTVCKDMNFPTWTLPP GVHSQTLSQFFNKVQDLDRDFKTSS AKVTIQSILKELDELLEAPGDLETL PRFQQHCVATHLLDGLEDVLRGLSK NPSIGLLNFSYPAGTEFSLEVQKQV DRNVTLRQNQATMQLHWNLAQKSGD PGPSVVGLVSVPGMGKLLAEAPLVS EPENQVVRNETHQGLLPILLSDVIS AFLSNNDTQNLSSPVTFIFSHRSVI PRRKVLCVFWEHGQNGCGHWATTGC STMDTRDTSTICRCTHLSSFAVLMA PYDVQEEDPVLTHHHHHHHH
• Purity: > 95% by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.135 mg/mL
• Storage Buffer: Sterile PBS, pH7.4

Gene Information

• Gene Name: ADGRE2 adhesion G protein-coupled receptor E2 [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: ADGRE2
• Synonyms: ADGRE2; adhesion G protein-coupled receptor E2; EMR2; adhesion G protein-coupled receptor E2; EGF-like module receptor 2; EGF-like module-containing mucin-like hormone receptor-like 2; egf-like module containing, mucin-like, hormone receptor-like 2
• Gene ID: 654420
• mRNA Refseq: NM_001038662
• Protein Refseq: NP_001033751
• UniProt ID: Q2Q426

Reviews

09/24/2021

Demonstrates excellent stability and consistency in long-term storage.

03/15/2021

Provides accurate and reproducible quantification of the target protein in mass spectrometry analysis.

Q&As

Does ADGRE2 play a role in immune cell activation, migration, or adhesion, and what are the underlying mechanisms?

ADGRE2 plays a role in immune cell activation, migration, and adhesion through mechanisms involving [specific cellular processes or adhesion molecules].

What are the functional consequences of ADGRE2 activation or inhibition on immune cell function and immune responses?

Activation or inhibition of ADGRE2 has functional consequences on immune cell function and immune responses, impacting [specific immune cell activities or immune response outcomes].

What are the downstream signaling pathways activated by ADGRE2 and how do they contribute to cellular processes?

ADGRE2 activates specific downstream signaling pathways, including [specific signaling cascades], which contribute to various cellular processes, such as [specific immune cell activation or migration].

Are there any known ligands or interacting partners that bind to the ADGRE2 protein and modulate its function?

ADGRE2 interacts with specific ligands or interacting partners, such as [specific molecules or cell surface receptors], leading to the modulation of its function.

Can the expression or activity of ADGRE2 be modulated by pharmacological agents or genetic manipulation?

The expression or activity of ADGRE2 can be modulated by pharmacological agents that target [specific receptors or signaling pathways], or through genetic manipulation using [specific genetic tools or techniques].

What is the impact of ADGRE2 deficiency or knockout on immune cell phenotypes or immune responses?

Deficiency or knockout of ADGRE2 in immune cells leads to observable changes in immune cell phenotypes or altered immune responses, characterized by [specific immune cell dysfunctions or immune response impairments].

Does ADGRE2 play a role in specific diseases or pathological conditions, and if so, what are the associated mechanisms?

ADGRE2 is implicated in specific diseases or pathological conditions, such as [specific autoimmune diseases or inflammatory disorders], where it contributes to [specific disease mechanisms or immune dysregulation].

What is the subcellular localization and distribution pattern of ADGRE2 within immune cells or relevant cell types?

ADGRE2 exhibits a [specific subcellular localization pattern], with localization primarily observed in [specific cellular compartments, such as plasma membrane or endosomes].

How is the expression of ADGRE2 regulated under normal physiological conditions and in response to specific stimuli?

Under normal physiological conditions, the expression of ADGRE2 is tightly regulated and can be modulated in response to specific stimuli, such as [specific cytokines or inflammatory signals].

What is the tissue-specific expression pattern of the ADGRE2 protein across different organs and cell types?

The ADGRE2 protein exhibits a specific expression pattern across various tissues and cell types, with higher levels observed in [specific tissues or cell populations].