Recombinant Zebrafish ACOT11B

• Cat.No.: ACOT11B-3556Z
• Product Overview: Recombinant Zebrafish ACOT11B full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: acot11b acyl-CoA thioesterase 11b [ Danio rerio (zebrafish) ]
• Official Symbol: ACOT11B
• Gene ID: 641574
• mRNA Refseq: NM_001037572
• Protein Refseq: NP_001032661
• UniProt ID: Q2YDR6

Q&As

What other proteins or pathways are involved in regulating lipid metabolism and energy balance?

Lipid metabolism and energy balance are complex processes that involve multiple proteins, enzymes, receptors, and signaling pathways. Some other proteins that have been studied in relation to metabolic disorders include AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma (PPARγ), and adiponectin. Future research may identify additional targets for the development of new therapies.

How can ACOT11B be studied in humans?

ACOT11B can be studied in humans using a variety of methods, including genetic studies, transcriptomic analyses, proteomic analyses, and metabolic profiling. In animal models, ACOT11B activity can also be modulated using genetic manipulations or pharmacological interventions. However, any research involving human subjects would need to be approved by an ethics committee and follow appropriate guidelines for protecting privacy, confidentiality, and informed consent.

Could ACOT11B-targeted therapies be used in combination with other treatments for metabolic disorders?

It is possible that ACOT11B-targeted therapies could be used in combination with other treatments for metabolic disorders, such as lifestyle modifications, pharmacological interventions, or surgical procedures. However, more research is needed to determine which combinations of therapies would be most effective and safe.

What are the potential applications of ACOT11B protein?

ACOT11B protein has potential applications in the development of therapies for metabolic disorders such as obesity, type 2 diabetes, and cardiovascular disease. It has been proposed as a target for the development of new drugs that could modulate lipid metabolism and improve energy balance.

Are there any known side effects or risks associated with modulating ACOT11B activity?

The potential risks and side effects of modulating ACOT11B activity are not yet fully understood, as this area of research is still in its early stages. However, any new drug or therapy that targets ACOT11B would need to undergo rigorous safety and efficacy testing before it could be approved for clinical use.

What are some potential risks or concerns associated with ACOT11B-targeted therapies?

The potential risks and concerns associated with ACOT11B-targeted therapies are not yet fully understood and would depend on the specific targeting strategy used. For example, small molecule inhibitors can have off-target effects and may interact with other drugs, while biologics can have immunogenicity and other safety concerns. Additionally, long-term effects of targeting ACOT11B are still unclear and require further research.

What research has been done on the development of ACOT11B-targeted therapies?

Some studies have explored the use of natural compounds such as polyunsaturated fatty acids and resveratrol to modulate ACOT11B activity and improve metabolic function. Other studies have investigated the development of synthetic compounds that could specifically target ACOT11B or related proteins. However, more research is needed before ACOT11B-targeted therapies can be developed and tested in humans.

What are some potential applications of targeting ACOT11B?

Targeting ACOT11B could have potential applications in the treatment of metabolic disorders, such as obesity, type 2 diabetes, and fatty liver disease. Additionally, ACOT11B may play a role in the development of certain types of cancer, so targeting this protein could have applications in cancer therapy as well.

How does the function of ACOT11B compare to ACOT11A?

ACOT11A and ACOT11B are both members of the acyl-CoA thioesterase family and play a role in lipid metabolism. ACOT11A is primarily expressed in the liver and has been associated with systemic metabolic function, while ACOT11B is expressed in multiple tissues and has been shown to play a role in regulating lipid metabolism in adipose tissue. The function of ACOT11B in metabolic disorders is less well understood than ACOT11A, but both proteins may have potential applications as therapeutic targets.

Could ACOT11B be used as a biomarker for metabolic disorders?

The expression and activity of ACOT11B have been shown to be altered in animal models and human studies of obesity, type 2 diabetes, and other metabolic disorders. However, more research is needed to determine whether ACOT11B could be used as a reliable biomarker for these conditions in clinical settings.

Are there any ongoing clinical trials of ACOT11B-targeted therapies?

There are currently no known clinical trials of ACOT11B-targeted therapies. However, as this area of research continues to develop, it is possible that clinical trials may be initiated in the future.

What challenges or opportunities are there for developing ACOT11B-targeted therapies?

One challenge for developing ACOT11B-targeted therapies is that the function and regulation of this protein are not fully understood. Additionally, any new therapy would need to undergo rigorous testing for safety and efficacy before it could be approved for clinical use. However, the potential benefits of developing new treatments for metabolic disorders are substantial, given the growing prevalence and impact of these conditions on global health.

Can ACOT11B be targeted with small molecules or biologics?

ACOT11B could potentially be targeted with small molecule inhibitors or activators, as well as with biologics such as monoclonal antibodies or RNA-based therapeutics. However, more research is needed to identify the most effective and specific targeting strategies for this protein.

Could ACOT11B-targeted therapies be used as preventive measures for metabolic disorders?

It is possible that ACOT11B-targeted therapies could be used as preventive measures for metabolic disorders, especially in at-risk populations. However, more research is needed to determine the optimal timing and dosing of these therapies for maximum benefit.

What are the challenges or limitations to the use of ACOT11B as a therapeutic target?

One challenge to the use of ACOT11B as a therapeutic target is that its functions and mechanisms are not fully understood. Additionally, targeting a single protein such as ACOT11B is unlikely to provide a complete solution to complex metabolic disorders. More research is needed to identify the most effective and safe ways to modulate ACOT11B activity.