Recombinant Zebrafish AHR1A

• Cat.No.: AHR1A-8657Z
• Product Overview: Recombinant Zebrafish AHR1A full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ahr1a aryl hydrocarbon receptor 1a [ Danio rerio (zebrafish) ]
• Official Symbol: AHR1A
• Gene ID: 246224
• mRNA Refseq: NM_131028
• Protein Refseq: NP_571103
• UniProt ID: Q8QGQ3

Reviews

01/18/2022

Couldn't be happier with the amazing quality, prompt delivery, and friendly service – worth every penny!

08/12/2021

The ordering process was smooth, and the recombinant proteins arrived on time and intact

07/14/2019

The efficiency of this protein is outstanding. Saved me a lot of time!

07/11/2019

From top-notch product quality to excellent customer service, they've got it all covered – truly impressed!

04/21/2019

Top-notch quality, friendly price, and their customer service was super helpful!

Q&As

How does AHR1A participate in the regulation of circadian rhythm and metabolic homeostasis?

AHR1A can influence circadian rhythm and metabolic homeostasis by interacting with clock genes and metabolic regulators, affecting processes like glucose and lipid metabolism.

How does AHR1A contribute to carcinogenesis, and what mechanisms underlie its role in promoting tumorigenesis?

AHR1A activation has been implicated in promoting tumorigenesis through the upregulation of genes involved in cell proliferation and inflammation. Additionally, AHR1A can enhance the metabolism of pro-carcinogenic compounds, leading to DNA damage and mutagenesis.

Describe the AHR1A signaling pathway and its downstream effects on gene expression?

Upon activation, AHR1A forms a heterodimer with the ARNT (AHR nuclear translocator) protein, which translocates to the nucleus. The AHR1A-ARNT complex binds to specific DNA sequences known as xenobiotic response elements (XREs) in the promoters of target genes, resulting in altered gene expression.

How does AHR1A influence the immune system and immune responses?

AHR1A activation can modulate immune responses by affecting the differentiation and function of immune cells. It can promote regulatory T cell development while inhibiting pro-inflammatory Th17 cell differentiation.

Describe the crosstalk between AHR1A signaling and other pathways, such as the NF-κB pathway.

AHR1A can interact with the NF-κB pathway, influencing inflammation and immune responses. Activation of AHR1A can inhibit NF-κB activity, leading to reduced expression of pro-inflammatory cytokines.

What are the structural domains of the AHR1A protein, and how do they contribute to its function?

AHR1A contains several functional domains, including the ligand-binding domain (LBD) responsible for ligand recognition and the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) domains involved in dimerization and DNA binding.

How does AHR1A contribute to the toxic effects of environmental pollutants, such as dioxins?

AHR1A is a key mediator of the toxic effects of dioxins and related compounds. Binding of dioxins to AHR1A leads to sustained activation of its target genes, which can disrupt various physiological processes and contribute to toxicity.

What are the primary ligands that activate AHR1A, and how does this activation occur?

AHR1A is activated by ligands such as polycyclic aromatic hydrocarbons (PAHs), dioxins, and heterocyclic amines. Upon ligand binding, AHR1A undergoes a conformational change, leading to its translocation into the nucleus and subsequent gene regulation.

How is AHR1A involved in the detoxification and clearance of endogenous metabolites in the body?

AHR1A plays a role in the detoxification of endogenous metabolites through the regulation of phase II drug-metabolizing enzymes, such as UDP-glucuronosyltransferases (UGTs) and glutathione S-transferases (GSTs).

What role does AHR1A play in drug metabolism, and how can it influence the pharmacokinetics of xenobiotics?

AHR1A plays a critical role in the regulation of drug-metabolizing enzymes, such as cytochrome P450 family members. Its activation can lead to increased metabolism of drugs, affecting their bioavailability and clearance.