AHR1A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Zebrafish | AHR1A-8657Z | Recombinant Zebrafish AHR1A | Mammalian Cell | His |
|
- Involved Pathway
- Protein Function
- Interacting Protein
AHR1A involved in several pathways and played different roles in them. We selected most pathways AHR1A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AHR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
AHR1A has several biochemical functions, for example, DNA binding, NOT aryl hydrocarbon receptor activity, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AHR1A itself. We selected most functions AHR1A had, and list some proteins which have the same functions with AHR1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | HIVEP2;TOPORS;CASZ1;ZFP276;INSM1B;DNAJC2;HMGB2;ENG2B;HOXB8B |
| NOT aryl hydrocarbon receptor activity | |
| protein dimerization activity | HER15.1;AHR;ATP6V1C2;SRFA;NPAS1;MXD4;USF1L;FBXW11A;HIF3A |
| transcription factor activity, sequence-specific DNA binding | ZNF621;TP73;ZNF207;SIM2;ELK1;NKX2-5;RAI1;TBX5;FOXJ1 |
AHR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of AHR1A.
- Q&As
- Reviews
Q&As (10)
Ask a questionAHR1A can influence circadian rhythm and metabolic homeostasis by interacting with clock genes and metabolic regulators, affecting processes like glucose and lipid metabolism.
AHR1A activation has been implicated in promoting tumorigenesis through the upregulation of genes involved in cell proliferation and inflammation. Additionally, AHR1A can enhance the metabolism of pro-carcinogenic compounds, leading to DNA damage and mutagenesis.
Upon activation, AHR1A forms a heterodimer with the ARNT (AHR nuclear translocator) protein, which translocates to the nucleus. The AHR1A-ARNT complex binds to specific DNA sequences known as xenobiotic response elements (XREs) in the promoters of target genes, resulting in altered gene expression.
AHR1A activation can modulate immune responses by affecting the differentiation and function of immune cells. It can promote regulatory T cell development while inhibiting pro-inflammatory Th17 cell differentiation.
AHR1A can interact with the NF-κB pathway, influencing inflammation and immune responses. Activation of AHR1A can inhibit NF-κB activity, leading to reduced expression of pro-inflammatory cytokines.
AHR1A contains several functional domains, including the ligand-binding domain (LBD) responsible for ligand recognition and the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) domains involved in dimerization and DNA binding.
AHR1A is a key mediator of the toxic effects of dioxins and related compounds. Binding of dioxins to AHR1A leads to sustained activation of its target genes, which can disrupt various physiological processes and contribute to toxicity.
AHR1A is activated by ligands such as polycyclic aromatic hydrocarbons (PAHs), dioxins, and heterocyclic amines. Upon ligand binding, AHR1A undergoes a conformational change, leading to its translocation into the nucleus and subsequent gene regulation.
AHR1A plays a role in the detoxification of endogenous metabolites through the regulation of phase II drug-metabolizing enzymes, such as UDP-glucuronosyltransferases (UGTs) and glutathione S-transferases (GSTs).
AHR1A plays a critical role in the regulation of drug-metabolizing enzymes, such as cytochrome P450 family members. Its activation can lead to increased metabolism of drugs, affecting their bioavailability and clearance.
Customer Reviews (5)
Write a reviewCouldn't be happier with the amazing quality, prompt delivery, and friendly service – worth every penny!
The ordering process was smooth, and the recombinant proteins arrived on time and intact
The efficiency of this protein is outstanding. Saved me a lot of time!
From top-notch product quality to excellent customer service, they've got it all covered – truly impressed!
Top-notch quality, friendly price, and their customer service was super helpful!
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