Recombinant Zebrafish AHR2

• Cat.No.: AHR2-8859Z
• Product Overview: Recombinant Zebrafish AHR2 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ahr2 aryl hydrocarbon receptor 2 [ Danio rerio (zebrafish) ]
• Official Symbol: AHR2
• Gene ID: 30517
• mRNA Refseq: NM_131264
• Protein Refseq: NP_571339
• UniProt ID: Q9YGV3

Reviews

11/09/2021

Couldn't have asked for a better combination of quality, service, and value.

07/15/2020

Quality that speaks for itself, along with fantastic customer service and timely delivery.

05/22/2019

The perfect blend of great quality and affordable pricing – plus, delivery was a breeze!

03/28/2019

Impressed by the competitive pricing, superior quality, and outstanding customer support.

02/09/2019

Exceptional service, reasonable pricing, and the product quality exceeded expectations.

Q&As

How does AHR2 activation influence epigenetic modifications and chromatin remodeling at target gene promoters?

AHR2 activation can influence epigenetic modifications, such as DNA methylation and histone acetylation, at target gene promoters. These changes contribute to the regulation of gene expression in response to ligand binding.

Describe the crosstalk between AHR2 signaling and other signaling pathways, such as the Wnt/β-catenin pathway.

AHR2 signaling can crosstalk with the Wnt/β-catenin pathway, influencing cell proliferation and differentiation. This crosstalk is relevant in the context of tissue regeneration and certain pathological conditions.

Discuss the role of AHR2 in the immune system and its impact on immune cell differentiation and function.

AHR2 regulates immune cell differentiation, particularly affecting the development and function of innate lymphoid cells and regulatory T cells. It can modulate immune responses to pathogens and regulate tissue-specific immune tolerance.

How does AHR2 contribute to the detoxification of xenobiotics and environmental pollutants?

AHR2 activation leads to the upregulation of drug-metabolizing enzymes, such as cytochrome P450 (CYP) enzymes, which play a crucial role in the detoxification and clearance of xenobiotics and environmental pollutants.

What is the role of AHR2 in maintaining the gut barrier integrity and preventing intestinal inflammation?

AHR2 activation is essential for maintaining the gut barrier integrity by regulating the expression of genes involved in tight junctions and mucosal defense. Dysregulation of AHR2 signaling may contribute to intestinal inflammation and inflammatory bowel diseases.

Discuss the role of AHR2 in regulating the metabolism of endogenous compounds and its impact on homeostasis?

AHR2 is involved in the regulation of endogenous metabolites, including bile acids and tryptophan derivatives, which can affect various physiological processes, such as lipid metabolism and immune responses.

Describe the ligand-binding properties of AHR2 and its affinity for environmental toxicants?

AHR2 exhibits a broader ligand-binding specificity compared to AHR1A. It has higher affinity for certain environmental toxicants, such as halogenated aromatic hydrocarbons, which are common pollutants in the environment.

How does AHR2 contribute to the pathogenesis of liver diseases, such as non-alcoholic fatty liver disease (NAFLD)?

AHR2 activation has been implicated in the regulation of lipid metabolism and inflammation in the liver, making it a potential factor in the development and progression of NAFLD and other liver diseases.

How is AHR2 involved in developmental processes, particularly in embryogenesis and organogenesis?

AHR2 plays a critical role in embryonic development and organogenesis, similar to AHR1A. It regulates genes involved in developmental processes, such as neurogenesis, cardiovascular development, and hematopoiesis.

How do AHR2 polymorphisms impact its function and influence individual susceptibility to environmental toxins and diseases?

Genetic variations in the AHR2 gene can lead to altered AHR2 function and affect individual susceptibility to environmental toxins and diseases, similar to AHR1A polymorphisms.