AHR2
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Zebrafish | AHR2-8859Z | Recombinant Zebrafish AHR2 | Mammalian Cell | His |
|
- Involved Pathway
- Protein Function
- Interacting Protein
AHR2 involved in several pathways and played different roles in them. We selected most pathways AHR2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AHR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
AHR2 has several biochemical functions, for example, DNA binding, contributes_to DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHR2 itself. We selected most functions AHR2 had, and list some proteins which have the same functions with AHR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | SERPINA3;POLR2C;ZNF529;AHR;CDX1A;ZNF35;CENPC1;VOX;LASS4 |
| contributes_to DNA binding | MAFGB;FOXH1;AHR2;RFC3;MCM7;NFE2L2A;SMAD2;GTF3C4;GTF3C3 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | RORAB;HNF4G;RXRA;NR5A2;NR2F6B;NR5A1B;NR1H4;PPARAB;NR2F6 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | JUNBA;ZNF488;TFAP2A;ERG;ELK4;FOXG1D;CC2D1A;GATA6;SP4 |
| aryl hydrocarbon receptor activity | ARNT;AHR2 |
| protein dimerization activity | CLOCK;ZBED1;ASCL1B;STK4;EBF4;POLR2J;ATM;PDCD6;AHR1A |
| sequence-specific DNA binding | MKX;NKX2.3;ASCL1A;ARGFX;PRRXL1;IRX4B;DLX2B;VDRA;HSFY1 |
AHR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AHR2.
- Q&As
- Reviews
Q&As (10)
Ask a questionAHR2 activation can influence epigenetic modifications, such as DNA methylation and histone acetylation, at target gene promoters. These changes contribute to the regulation of gene expression in response to ligand binding.
AHR2 signaling can crosstalk with the Wnt/β-catenin pathway, influencing cell proliferation and differentiation. This crosstalk is relevant in the context of tissue regeneration and certain pathological conditions.
AHR2 regulates immune cell differentiation, particularly affecting the development and function of innate lymphoid cells and regulatory T cells. It can modulate immune responses to pathogens and regulate tissue-specific immune tolerance.
AHR2 activation leads to the upregulation of drug-metabolizing enzymes, such as cytochrome P450 (CYP) enzymes, which play a crucial role in the detoxification and clearance of xenobiotics and environmental pollutants.
AHR2 activation is essential for maintaining the gut barrier integrity by regulating the expression of genes involved in tight junctions and mucosal defense. Dysregulation of AHR2 signaling may contribute to intestinal inflammation and inflammatory bowel diseases.
AHR2 is involved in the regulation of endogenous metabolites, including bile acids and tryptophan derivatives, which can affect various physiological processes, such as lipid metabolism and immune responses.
AHR2 exhibits a broader ligand-binding specificity compared to AHR1A. It has higher affinity for certain environmental toxicants, such as halogenated aromatic hydrocarbons, which are common pollutants in the environment.
AHR2 activation has been implicated in the regulation of lipid metabolism and inflammation in the liver, making it a potential factor in the development and progression of NAFLD and other liver diseases.
AHR2 plays a critical role in embryonic development and organogenesis, similar to AHR1A. It regulates genes involved in developmental processes, such as neurogenesis, cardiovascular development, and hematopoiesis.
Genetic variations in the AHR2 gene can lead to altered AHR2 function and affect individual susceptibility to environmental toxins and diseases, similar to AHR1A polymorphisms.
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