Recombinant Zebrafish AIFM4

• Cat.No.: AIFM4-5167Z
• Product Overview: Recombinant Zebrafish AIFM4 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: aifm4 apoptosis-inducing factor, mitochondrion-associated, 4 [ Danio rerio (zebrafish) ]
• Official Symbol: AIFM4
• Gene ID: 791218
• mRNA Refseq: NM_001080700
• Protein Refseq: NP_001074169
• UniProt ID: A1L230

Reviews

04/07/2023

the superior quality of the AIFM4 protein, coupled with the manufacturer's exceptional technical support, positions it as an invaluable asset for my experimental endeavors.

06/14/2020

Their prompt and reliable support enables me to navigate through protocols, troubleshoot problems, and interpret complex data, guaranteeing the timely completion of my research objectives.

05/03/2018

By relying on its reliability and the manufacturer's expertise,significantly advancing our understanding in this field.

Q&As

What are the potential clinical applications of understanding the function of AIFM4 protein?

Understanding the function of AIFM4 protein can lead to the development of new therapies for diseases that involve mitochondrial dysfunction or abnormal apoptosis, such as neurodegenerative diseases and cancer. Additionally, AIFM4 protein may serve as a biomarker for certain diseases or as a target for therapeutic interventions.

How does AIFM4 protein differ from other mitochondrial proteins such as cytochrome c or ATP synthase?

AIFM4 protein differs from other mitochondrial proteins such as cytochrome c or ATP synthase in several ways. One of the main differences is their function- cytochrome c and ATP synthase are involved in energy production and transfer in the mitochondria, while AIFM4 is primarily involved in regulating apoptosis and cell death pathways. Additionally, AIFM4 is a relatively unknown protein compared to cytochrome c and ATP synthase, which have been extensively studied and characterized.

How is AIFM4 protein regulated?

The regulation of AIFM4 protein expression and activity is currently poorly understood. Some studies suggest that it may be regulated by post-translational modifications such as phosphorylation, acetylation or ubiquitination.

How can a better understanding of AIFM4 protein contribute to cancer research?

A better understanding of AIFM4 protein can contribute to cancer research by providing insights into the regulation of apoptosis and cell death pathways that are frequently disrupted in cancer cells. Additionally, the role of AIFM4 protein in regulating mitochondrial function may be relevant to cancer metabolism, which is characterized by altered energy production and utilization pathways. These insights can guide the development of new cancer therapies that target AIFM4 protein or related cellular pathways.

Are there any ongoing studies investigating the role of AIFM4 protein?

There is currently limited ongoing research investigating the role of AIFM4 protein in disease. However, increased studies are needed to fully understand the potential role of this protein in disease pathogenesis.

Can AIFM4 protein be used as a therapeutic target for disease?

It is currently unclear if AIFM4 protein can be used as a therapeutic target for disease. More research is needed to determine its exact function and potential role in disease pathogenesis.

Is there any association between AIFM4 protein and disease?

There is currently limited information on the association between AIFM4 protein and disease. However, some studies have suggested that it may be involved in the pathogenesis of certain diseases such as Parkinson's disease and cancers.

What are the potential implications of understanding the function of AIFM4 protein?

Understanding the function of AIFM4 protein can provide insight into the mechanisms underlying mitochondrial function and apoptosis regulation. This knowledge can lead to the development of new therapies for diseases that involve mitochondrial dysfunction or abnormal apoptosis, such as neurodegenerative diseases and cancer.

How is AIFM4 protein studied?

AIFM4 protein can be studied using various biochemical and molecular biology techniques. These include Western blotting, immunofluorescence staining, RNA interference, and overexpression experiments in cell culture systems. Additionally, animal models can be used to investigate the role of AIFM4 protein in vivo.

Is there any evidence to suggest that AIFM4 protein plays a role in brain function or neurodegenerative diseases?

Yes, some studies suggest that AIFM4 protein may be involved in brain function and the pathogenesis of neurodegenerative diseases such as Parkinson's disease. Specifically, it has been proposed that AIFM4 protein may play a role in regulating mitochondrial function and cell death in dopaminergic neurons, which are specifically affected in Parkinson's disease.

Are there any known diseases or disorders associated with mutations in the AIFM4 gene?

Currently, there are no known diseases or disorders that are specifically associated with mutations in the AIFM4 gene. However, some studies have suggested that alterations in AIFM4 expression or function may be involved in the development of certain diseases, including cancer.

Can AIFM4 protein be used as a biomarker for any diseases or conditions?

Currently, AIFM4 protein has not been established as a biomarker for any diseases or conditions. However, ongoing research studies may provide insights into the potential use of AIFM4 protein as a biomarker in the future.

Are there any drugs that target AIFM4 protein?

Currently, there are no drugs that specifically target AIFM4 protein. However, some drugs that target other proteins involved in mitochondrial function or apoptosis may indirectly affect the activity of AIFM4 protein.

Are there any ongoing research studies focused on AIFM4 protein?

Yes, there are ongoing research studies focused on AIFM4 protein. Some studies are aimed at understanding the molecular mechanisms underlying AIFM4 function and regulation, while others are focused on elucidating the role of AIFM4 in various cellular processes and disease states. Additionally, some research studies are aimed at developing new drugs or therapeutic strategies that target AIFM4 or related pathways.

Can mutations in the AIFM4 gene cause disease?

Currently, there is no evidence to suggest that mutations in the AIFM4 gene cause disease. However, further studies are needed to fully understand the potential effects of genetic variation in this gene on health and disease.

What are some of the challenges in studying AIFM4 protein?

One of the main challenges in studying AIFM4 protein is its relatively unknown function compared to other mitochondrial proteins. Additionally, AIFM4 protein is highly conserved across different species, which makes it difficult to generate animal models with altered AIFM4 expression or function. Furthermore, the low abundance of AIFM4 protein within the cell makes it challenging to detect and study its activity using traditional biochemical and imaging techniques.