Recombinant Zebrafish AMBRA1B

• Cat.No.: AMBRA1B-8476Z
• Product Overview: Recombinant Zebrafish AMBRA1B full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ambra1b activating molecule in BECN1-regulated autophagy protein 1-like [ Danio rerio (zebrafish) ]
• Official Symbol: AMBRA1B
• Gene ID: 559106
• mRNA Refseq: NM_001302220
• Protein Refseq: NP_001289149

Reviews

02/15/2020

Reduced assay variability in large-scale protein studies.

05/22/2019

Minimal assay interference from endogenous inhibitors.

12/05/2017

High specificity in target protein localization studies.

Q&As

How does the expression of AMBRA1B differ from AMBRA1A in different cell types or tissues?

The expression of AMBRA1B may differ from AMBRA1A in a cell-type or tissue-specific manner, indicating potential functional diversity.

What are the functional consequences of AMBRA1B isoform-specific interactions with autophagy-related proteins?

The isoform-specific interactions of AMBRA1B with autophagy-related proteins can have distinct functional consequences, influencing autophagy regulation and cargo recognition.

Does AMBRA1B have isoform-specific effects on autophagosome maturation and lysosomal fusion?

AMBRA1B may exhibit isoform-specific effects on autophagosome maturation and lysosomal fusion, impacting the efficiency and specificity of cargo degradation.

What are the differences in the subcellular localization and dynamics of AMBRA1B compared to AMBRA1A during autophagy induction?

AMBRA1B may exhibit differences in subcellular localization and dynamics compared to AMBRA1A during autophagy induction, indicating potential distinct roles in autophagosome formation and trafficking.

What is the impact of AMBRA1B overexpression or knockdown on cellular autophagy levels and flux?

Manipulation of AMBRA1B expression levels, either through overexpression or knockdown, can modulate cellular autophagy levels and flux, potentially impacting cellular homeostasis.

How does AMBRA1B modulate the activity of Beclin 1 and other autophagy initiation factors?

AMBRA1B may modulate the activity of Beclin 1 and other autophagy initiation factors in a manner that differs from AMBRA1A, contributing to isoform-specific autophagy regulation.

How is the post-translational modification pattern of AMBRA1B distinct from AMBRA1A and how does it affect its function in autophagy?

The post-translational modification pattern of AMBRA1B could differ from AMBRA1A, potentially affecting its stability, interaction partners, and overall function in autophagy.

What is the role of AMBRA1B in selective autophagy pathways, such as mitophagy or xenophagy?

AMBRA1B likely participates in selective autophagy pathways, such as mitophagy or xenophagy, potentially influencing the clearance of specific cellular targets.

Are there specific cellular or environmental conditions that regulate the alternative splicing and expression of AMBRA1B?

Specific cellular or environmental conditions may regulate the alternative splicing and expression of AMBRA1B, leading to isoform-specific regulation of autophagy under certain contexts.

How does AMBRA1B influence the interaction between autophagy and other cellular processes, such as apoptosis or immune responses?

AMBRA1B's interaction with other cellular processes, such as apoptosis or immune responses, may influence the crosstalk between autophagy and these pathways, contributing to cellular fate determination.