Recombinant Zebrafish ARHGAP12B

• Cat.No.: ARHGAP12B-11122Z
• Product Overview: Recombinant Zebrafish ARHGAP12B full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: arhgap12b Rho GTPase activating protein 12b [ Danio rerio (zebrafish) ]
• Official Symbol: ARHGAP12B
• Gene ID: 393848
• mRNA Refseq: NM_200874
• Protein Refseq: NP_957168
• UniProt ID: Q6P4P5

Reviews

11/12/2022

The manufacturer can further support researchers by providing customized solutions tailored to their specific needs.

08/25/2022

This collaborative partnership greatly contributes to the success of my research projects and facilitates meaningful contributions to the scientific community.

07/09/2022

Its reliability, versatility, and ability to deliver clear and reliable results make it a top choice for researchers in need of a high-quality protein for their experiments.

11/27/2020

This enhanced visibility and distinctness of the protein bands greatly aided in the accurate analysis and interpretation of my Western Blotting results.

01/10/2020

The manufacturer's support and expertise further enhance the utility of ARHGAP12B in my experimental work, ensuring reliable and high-quality results.

04/29/2017

Another advantage of using ARHGAP12B protein in trials is its potential as a therapeutic agent.

10/02/2016

ARHGAP12B protein has exhibited remarkable performance in Western Blotting experiments.

07/02/2016

The reliable and high-quality results obtained using ARHGAP12B protein make it an excellent choice for researchers studying protein structures.

Q&As

Are there any known regulators of ARHGAP12B expression?

The regulatory mechanisms controlling ARHGAP12B expression have not been extensively studied. However, transcription factors or signaling pathways may potentially regulate its expression. Further research is needed to identify its regulators.

Is ARHGAP12B conserved across different species?

ARHGAP12B exhibits a moderate level of conservation across different species, including mammals. However, the extent of conservation and its functional implications need further investigation.

Are there any known genetic variants or mutations in ARHGAP12B associated with neurodevelopmental disorders?

No specific genetic variants or mutations in ARHGAP12B have been identified as causative factors for neurodevelopmental disorders thus far. However, given its potential role in brain development and its association with human-specific features, further genetic studies may reveal potential links between ARHGAP12B and neurodevelopmental disorders.

Can ARHGAP12B interact with other proteins within the Rho family GTPases?

Although not yet fully characterized, it is plausible that ARHGAP12B can interact with Rho family GTPases, given its predicted RhoGAP domain. These interactions could potentially regulate the activity and signaling of these GTPases.

Are there any known genetic polymorphisms in ARHGAP12B?

Currently, there are no well-characterized genetic polymorphisms reported in the ARHGAP12B gene. However, further research is necessary to identify common polymorphisms and their potential functional implications.

Can ARHGAP12B affect cell migration and invasion?

Considering its predicted role in Rho GTPase signaling, which is critical for cell migration and invasion, it is possible that ARHGAP12B could influence these cellular processes. However, functional studies are needed to determine the direct impact of ARHGAP12B on cell migration and invasion.

Has ARHGAP12B been associated with any neurodevelopmental disorders?

There is currently no known association between ARHGAP12B and neurodevelopmental disorders. However, genetic studies and functional investigations are required to explore its potential contributions to these conditions.

Is ARHGAP12B involved in any specific developmental processes?

The involvement of ARHGAP12B in developmental processes is not well established. However, as it is expressed in the brain, it may play a role in neuronal development or synaptic plasticity.

Does ARHGAP12B have any known cellular or physiological roles?

The specific cellular or physiological roles of ARHGAP12B are still largely unknown. However, given its potential involvement in cytoskeletal regulation, it may play a role in cell migration, adhesion, or other processes requiring dynamic cytoskeletal rearrangements.

Are there any disease associations or mutations identified in the ARHGAP12B gene?

There are currently no known disease associations or mutations identified in the ARHGAP12B gene. However, further research is needed to fully characterize its genetic variants and assess any potential disease links.

Does ARHGAP12B have any known protein-protein interaction domains?

ARHGAP12B contains a predicted RhoGAP domain, which suggests its potential to interact with Rho family GTPases. However, other protein-protein interaction domains have not been reported.

Does ARHGAP12B have any post-translational modifications?

The post-translational modifications of ARHGAP12B have not been extensively studied. However, it is predicted to contain several phosphorylation sites, suggesting potential regulation through phosphorylation-mediated events.

Is ARHGAP12B expressed in all tissues?

ARHGAP12B shows a tissue-specific expression pattern, with higher levels reported in the brain, particularly in the cortex and hippocampus. It is also expressed in the testis, kidney, and adrenal gland, albeit at lower levels.

Are there any inhibitors or activators known to modulate ARHGAP12B activity?

Currently, there are no known specific inhibitors or activators that directly modulate ARHGAP12B activity. Further research is warranted to identify potential molecules capable of modulating its function.

Can ARHGAP12B interact with other proteins to form complexes or signaling pathways?

The protein interactions and potential complex formations involving ARHGAP12B are not well characterized. Further studies are needed to identify its binding partners and elucidate its role in signaling pathways.

Can ARHGAP12B be targeted for therapeutic interventions?

Given the limited knowledge of ARHGAP12B's function and its role in disease, it is currently unclear if it can be targeted for therapeutic interventions. More research is needed to determine its potential as a therapeutic target.