Recombinant Zebrafish ARPC5LA

• Cat.No.: ARPC5LA-10856Z
• Product Overview: Recombinant Zebrafish ARPC5LA full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: arpc5la actin related protein 2/3 complex, subunit 5-like, a [ Danio rerio (zebrafish) ]
• Official Symbol: ARPC5LA
• Gene ID: 393550
• mRNA Refseq: NM_200578
• Protein Refseq: NP_956872
• UniProt ID: Q6P0D3

Reviews

04/26/2023

In addition to the remarkable protein quality, the manufacturer provides excellent technical support, proving to be a valuable resource when troubleshooting experimental challenges.

10/26/2018

Whether investigating metabolic pathways, studying enzymatic activity, or exploring drug targets, this protein offers versatility and reliability, allowing for accurate and meaningful data collection.

03/28/2018

Their expertise and prompt assistance can effectively address any concerns or challenges that may arise during the experimental process.

Q&As

Are there any diseases or disorders associated with ARPC5LA dysfunction?

Currently, there are no specific diseases or disorders directly linked to ARPC5LA dysfunction. However, as a component of the Arp2/3 complex, dysregulation or mutations in other subunits of the complex have been associated with various cellular abnormalities, including developmental disorders, cancer metastasis, and autoimmune diseases.

How is the ARPC5LA protein localized within the cell?

ARPC5LA is primarily localized in the cytoplasm of cells, where it interacts with other subunits of the Arp2/3 complex. However, it may also transiently localize to the plasma membrane or other cellular compartments during dynamic processes such as cell migration or membrane remodeling.

Are there any known interacting proteins or binding partners of ARPC5LA?

As a subunit of the Arp2/3 complex, ARPC5LA interacts with other subunits of the complex, including ARPC1, ARPC2, ARPC3, and ARPC4. It also interacts with Nucleation Promoting Factors (NPFs), which are proteins that initiate actin filament nucleation and regulate Arp2/3 complex activity.

Is ARPC5LA specific to certain cell types or tissues?

ARPC5LA is expressed in a wide range of cell types and tissues, suggesting that it has a general role in actin cytoskeleton regulation. However, the relative abundance or specific functions of ARPC5LA in different tissues or cell types may vary.

Can ARPC5LA be targeted by inhibitors or drugs?

Since ARPC5LA is an integral part of the Arp2/3 complex, its activity can potentially be targeted by drugs or inhibitors that modulate the function of the entire complex. Small-molecule inhibitors that interfere with Arp2/3 complex activity or inhibitors that disrupt the interaction between the complex and NPFs may indirectly affect the function of ARPC5LA.