Recombinant Zebrafish ARSA

• Cat.No.: ARSA-2206Z
• Product Overview: Recombinant Zebrafish ARSA full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: arsa arylsulfatase A [ Danio rerio (zebrafish) ]
• Official Symbol: ARSA
• Gene ID: 541416
• mRNA Refseq: NM_001013543
• Protein Refseq: NP_001013561
• UniProt ID: Q5BL32

Reviews

12/20/2021

By utilizing the ARSA protein, I can approach my research with unwavering confidence in its quality, along with the unparalleled support provided by its manufacturer.

03/05/2020

I am genuinely excited to embark on this scientific journey, empowered by the superior ARSA protein and the manufacturer's unwavering commitment to ensuring my success.

10/01/2017

The ARSA protein comes highly recommended due to its exceptional performance in ELISA assays.

Q&As

Are there any known genetic variations in the ARSA gene?

Yes, several genetic variations, including point mutations, deletions, and insertions, have been identified in the ARSA gene. These variations can lead to reduced ARSA activity and are responsible for different types and severities of metachromatic leukodystrophy.

Can ARSA deficiency be treated?

At present, there is no cure for metachromatic leukodystrophy caused by ARSA deficiency. However, there are some treatments available that aim to manage the symptoms and slow disease progression, such as enzyme replacement therapy and hematopoietic stem cell transplantation. Research is ongoing to develop more effective therapeutic strategies for this condition.

What happens if ARSA is deficient?

Deficiency of ARSA activity results in the accumulation of sulfatides within cells, particularly in the central and peripheral nervous systems. This buildup leads to the destruction of myelin, impairing nerve signal transmission and causing the symptoms associated with metachromatic leukodystrophy (MLD), such as motor and cognitive deterioration.

Is ARSA protein associated with any other diseases besides metachromatic leukodystrophy?

Yes, in addition to MLD, alterations in ARSA activity have been implicated in certain types of multiple sclerosis (MS). Although the exact relationship is not fully understood, it is believed that decreased ARSA function may contribute to the pathogenesis of certain forms of MS.