Recombinant Zebrafish ATXN1A

• Cat.No.: ATXN1A-3958Z
• Product Overview: Recombinant Zebrafish ATXN1A full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: atxn1a ataxin 1a [ Danio rerio (zebrafish) ]
• Official Symbol: ATXN1A
• Gene ID: 557340
• mRNA Refseq: NM_001044826
• Protein Refseq: NP_001038291
• UniProt ID: Q1L966

Reviews

04/22/2022

The high activity of ATXN1A ensures its stable performance, making it a preferred choice for researchers.

05/27/2020

The wide applicability of ATXN1Aeins makes them play a key role in many fields of research and promotes the progress of science.

05/21/2019

This high stability of ATXN1A ensures its stable properties, making it a preferred choice for researchers.

Q&As

Which diseases are associated with ATXN1A?

ATXN1A gene is associated with spinocerebellar ataxia type 1 (SCA1). SCA1 is an inherited neurological disorder caused by mutations in the ATXN1A gene.

What is the regulatory mechanism of ATXN1A gene?

The expression of ATXN1A gene is affected by a variety of regulatory mechanisms, including the binding of transcriptional regulators, epigenetic modification, and regulation by non-coding RNA.

How do ATXN1A mutations cause SCA1?

The ATXN1A mutation leads to the expansion of glutamine repeats in the ATXN1A protein, resulting in the formation of abnormal polyglutamic acid protein. The abnormal accumulation of this protein can lead to abnormal function and degenerative changes of nerve cells, triggering the occurrence of SCA1.

What is the role of ATXN1A gene in human body?

The protein encoded by the ATXN1A gene plays an important role in the nervous system, involving in cell cycle regulation, transcriptional regulation, and protein degradation.

In which tissues is the ATXN1A gene expressed?

This gene is expressed in several tissues, but its expression is higher in the central nervous system, especially in the cerebellum and spinal cord.

Does ATXN1A gene interact with other genes?

Yes, the ATXN1A gene interacts with other genes to form a complex regulatory network. For example, ATXN1A protein interacts with Capicua (CIC) protein to participate in transcriptional regulation.