Hematopoietic Stem Cell Growth Factors
- Activins
- BMPs (Bone Morphogenetic Proteins)
- Common β Chain Receptor Family Ligands
- Common gamma Chain Receptor Family Ligands
- EGF Ligands
- FGF Ligands
- Growth Differentiation Factor (GDF)
- Hedgehogs
- IGF Ligands
- IL-6 Family Ligands
- Other Hematopoietic Stem Cell Growth Factors
- Platelet-Derived Growth Factors (PDGFs)
- Vascular Endothelial Growth Factors (VEGFs)
- Wnt Ligands (Wnts)
About Hematopoietic Stem Cell Growth Factors
Hematopoietic stem cells (HSCs) are self-renewing and pluripotent cells that can differentiate into different types of blood cells, including red blood cells, white blood cells, and platelets. Hematopoietic stem cell growth factors are a class of bioactive proteins that regulate and promote the proliferation and differentiation of hematopoietic stem cells. Hematopoietic stem cell growth factors regulate the proliferation, differentiation, and self-renewal of HSCs by binding to specific receptors and through signaling pathways. Over the years, several types have been identified, some of which are widely used and studied. Cytokines that affect hematopoiesis include cytokines that can be classified into the common β-chain, common γ-chain, and IL-6 cytokine families. Growth factors such as EGF, FGF, GDF, IGF, PDGF, and VEGF also affect hematopoietic stem cell differentiation. In addition, hematopoietic stem cell fate is modified by activin, bone morphogenetic protein (BMP), Hedgehog molecules, and Wnt-related molecules.
Hematopoietic stem cell growth factors are essential for the normal development and function of the hematopoietic system. They are widely used in clinical treatment and research, providing new therapeutic avenues and hope for addressing a range of blood disorders and hematopoietic dysfunctions.
Fig.1 Human hematopoiesis with characteristic markers, TFs, and miRNAs with potential approaches for HSCs in clinical applications. (Mann Z, et al., 2022)
Available Products and Services of Hematopoietic Stem Cell Growth Factors
We offer the following products related to hematopoietic stem cell growth factors, click to view all related molecules/targets and research reagents.
Our product types cover recombinant proteins, native proteins, protein pre-coupled magnetic beads, cell & tissue lysates, chromatography reagents, GMP proteins, lectins, assay kits, and others.
Creative BioMart also provides researchers with a series of resources about each hematopoietic stem cell growth factor, such as involved pathway, protein function, interacting protein, related articles, and research area, please visit the product details page.
Common Applications of Hematopoietic Stem Cell Growth Factors
- Hematopoietic stem cell culture and expansion
Hematopoietic stem cell growth factors can promote the proliferation and expansion of hematopoietic stem cells. In in vitro culture, the addition of appropriate growth factors can improve the yield and survival of HSCs. This is useful in situations where large numbers of HSCTs are needed for clinical transplantation or laboratory research.
- Hematopoietic stem cell differentiation
Hematopoietic stem cells can be induced to differentiate towards specific cell lines (such as red blood cells, white blood cells, and platelets) by adding specific growth factors. This helps to understand the regulatory mechanisms of hematopoietic cell differentiation, as well as stem cell therapeutic strategies in the treatment of blood-related diseases.
- Disease research and treatment
Researchers can use HSGF to explore the pathogenesis of various hematologic diseases, such as aplastic anemia and myelofibrosis. In addition, certain HSCGFs have been used to treat certain diseases or to promote regeneration after stem cell transplantation.
- Drug screening and therapeutic development
Drug screening and therapeutic development are possible through the use of hematopoietic stem cell growth factors. Researchers can evaluate the effects of new drugs on hematopoietic stem cells and develop more effective drug treatment strategies.
If you are interested in hematopoietic stem cell growth factors or need related products and services, you can make price inquiries and purchases through our online ordering system. Meanwhile, you can also directly contact our professional team for consultation and cooperation.
Reference:
- Mann Z, Sengar M, Verma YK, Rajalingam R, Raghav PK. Hematopoietic Stem Cell Factors: Their Functional Role in Self-Renewal and Clinical Aspects. Front Cell Dev Biol. 2022 Mar 24;10:664261. doi: 10.3389/fcell.2022.664261. PMID: 35399522; PMCID: PMC8987924.
- Huang, Xiaosong, Scott Cho, and Gerald J. Spangrude. "Hematopoietic stem cells: generation and self-renewal." Cell Death & Differentiation 14.11 (2007): 1851-1859.
- Zhang CC, Lodish HF. Cytokines regulating hematopoietic stem cell function. Curr Opin Hematol. 2008;15(4):307-311. doi:10.1097/MOH.0b013e3283007db5
