BAG3
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Official Full Name
BCL2-associated athanogene 3
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Overview
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] -
Synonyms
BAG3; BCL2-associated athanogene 3; BIS; MFM6; BAG-3; CAIR-1; BAG family molecular chaperone regulator 3; docking protein CAIR-1; BCL2-binding athanogene 3; bcl-2-binding protein Bis;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- BAG3 Related Research Area
BAG3 involved in several pathways and played different roles in them. We selected most pathways BAG3 participated on our site, such as Apoptosis Modulation and Signaling, Cellular response to heat stress, Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Apoptosis Modulation and Signaling | DIABLO;BAG3;CDKN2A;BOK;CRADD;PTRH2;DFFA;PTPN13;BCL2L11 |
Cellular response to heat stress | NUP35;ST13;RPS19BP1;MAPKAPK2B;HSPA12B;HDAC6;HSPH1;C11orf73;EEF1A1 |
Cellular responses to stress | SUZ12A;BMI1B;RAD50;RNF2;EGLN3;AGO1;HIST1H1C;CDKN2C;Txn1 |
Regulation of HSF1-mediated heat shock response | C11orf73;HSPA13;HSPH1;DNAJC2;BAG3;HSPA12B;KIAA1967;HSPA14;BAG5 |
BAG3 has several biochemical functions, for example, chaperone binding, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAG3 itself. We selected most functions BAG3 had, and list some proteins which have the same functions with BAG3. You can find most of the proteins on our site.
Function | Related Protein |
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chaperone binding | DNAJB4;BAK1;PARK2;VWF;CXorf41;DNAJA3B;HSPE1;CDC37L1;AHSA1L |
protein binding | PENK;FUBP1;DDIT4L;DNM2;LSM2;SDPR;NDUFAF1;TXLNG;KATNBL1 |
protein complex binding | PPIB;PRKACA;YWHAB;THRA;C8A;STK11;TUBB;UFD1L;VAMP2 |
BAG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAG3.
HSPB8; HSPB1; DAZAP2; STUB1; PDE9A
- Q&As
- Reviews
Q&As (6)
Ask a questionThe expression level of BAG3 protein can be quantitatively detected by Western blot, immunohistochemistry, real-time PCR and other technical methods.
This protein is involved in biological processes such as cardiomyocyte survival and metabolism, and plays an important role in the occurrence and progression of cardiomyopathy.
The specific regulatory mechanism of BAG3 protein can be explored to develop therapeutic strategies for its function, such as bioengineering drugs or cell gene therapy.
BAG3 protein plays an important role in regulating muscle cell life activities, metabolic processes and protein synthesis, and plays an important role in the occurrence and development of amyotrophic lateral sclerosis.
BAG3 protein plays an important role in the autophagy process, such as participating in the formation of autophagy membranes and inhibiting specific steps of autophagy pathways, affecting the occurrence and development of autophagy processes.
It is possible to develop specific targeted drugs for BAG3 protein, interfere with the binding of BAG3 protein to other apoptosis-regulatory proteins, etc., to affect the growth and metastasis of tumor cells.
Customer Reviews (3)
Write a reviewWith its wide applicability, it can play a key role in many fields of research and promote the progress of science.
The short half-life and high clearance properties of this recombinant protein make it a higher potential in drug research and development, which is expected to become a new generation of therapeutic drugs.
It's the most biologically active protein I've ever seen, and the purity of its production is impressive.
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