CDK5
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Official Full Name
CDK5 cyclin-dependent kinase 5
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Overview
Cyclin dependent kinase 5 (CdK5) is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells. -
Synonyms
Cyclin cdk5; CDK5; cyclin-dependent kinase 5; PSSALRE; OTTHUMP00000212917; OTTHUMP00000212939; TPKII catalytic subunit; protein kinase CDK5 splicing; cell division protein kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit; Cyclin dependent kinase 5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Sf9 insect cells
- Wheat Germ
- DDK
- Flag
- gst
- GST
- His
- His (Fc)
- Avi
- His|S
- SUMO
- Myc
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CDK5 Related Articles
- CDK5 Related Research Area
CDK5 involved in several pathways and played different roles in them. We selected most pathways CDK5 participated on our site, such as Alzheimers disease, Axon guidance, BDNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | BACE2;ATP5C1;NCSTN;CASP9;TNF;PPP3CC;ATF6;CAPN1;IL1B2 |
| Axon guidance | COL9A3;NCK2;SLIT2;TRPC4;LRRC4;PAK1;DPYSL2;PPP3CC;CSNK2B |
| BDNF signaling pathway | EEF2;DOK5;EGR2;JAK2;YBX1;BCL2L11;CDK5;GNB2L1;CFL1 |
| CRMPs in Sema3A signaling | CDK5R1B;CRMP1;DPYSL5A;SEMA3AB;DPYSL3;SEMA3A;DPYSL2;NRP1A;SEMA3AA |
| Cocaine addiction | GNAS;DRD1A;GRM2;SLC18A2;PRKACA;CREB5;DDC;GRIA2;SLC6A3 |
| DARPP-32 events | PRKAR1AA;CDK5 |
| DNA damage response | GADD45G;HUS1B;CHEK2;CDK5;RAD9A;DDB2;RAD1;GADD45A;TLK2 |
CDK5 has several biochemical functions, for example, ATP binding, ErbB-2 class receptor binding, ErbB-3 class receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK5 itself. We selected most functions CDK5 had, and list some proteins which have the same functions with CDK5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | KIF25;ACVR1C;TNK1;WRN;PDK2;ACTC1;ATP1A1A.2;ASCC3;CAMKK2 |
| ErbB-2 class receptor binding | CDK5;MUC4;NRG1 |
| ErbB-3 class receptor binding | ERBB2;NRG1;PIK3R1;CDK5 |
| acetylcholine receptor activator activity | |
| cyclin-dependent protein serine/threonine kinase activity | CDK15;CDK10;CDK11B;CDK1;MAK;CCND3;CDK17;CCNK;NAT1 |
| cytoskeletal protein binding | ACTN2;PKD2L1;TOR1AIP1;ANXA2B;ANXA2;EZRA;TNNT2A;FRMD5;RPH3AL |
| ephrin receptor binding | NTRK1;NTRK3;EFNB1;EFNB2;CDK5;FYN;EFNA1;Anks1;EFNA4 |
| kinase activity | NLK2;MIBP;ROCK2A;EPHB2B;BAIAP2L1A;KALRN;PRKAR2AA;PKN1B;MAPK8A |
| p53 binding | TP73;TRIM24;RCHY1;SETD7;CDK5;ANKRD1;BRD7;MDM2;TRIM29 |
| protein binding | HDDC3;PTPRO;RAD52;PIM1;ZFP259;TRIM11;ZNF317;CRTC2;ZNF624 |
| protein kinase activity | PRKACBA;ZNF143B;IKBKB;ROCK1;PKN1B;MAPKAPK2A;PDK4;AKT3A;SGK196 |
| protein kinase binding | CCNA2;STK11IP;HCLS1;CEP68;RELA;PRKAG2;SHC3;SCN5A;SOCS1 |
| protein serine/threonine kinase activity | RIPK1;TRIO;MAPK8A;STK11;MAPK14A;GM7168;MAP4K5;PAK2B;MAP4K4 |
| tau-protein kinase activity | CDK5;GSK3B;MARK2;PHKG1;PRKAA1;MARK1;PHKG2;CSNK1D;MARK4 |
CDK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK5.
CDKN1B; CCND2; CABLES1; CDKN1A
- Q&As
- Reviews
Q&As (6)
Ask a questionThe CDK5 is expressed from HEK293 host, which is a mammalian cells system.
CDK5 has been studied in relation to psychiatric disorders like schizophrenia and bipolar disorder due to its involvement in neuronal function and synaptic plasticity.
Yes, some studies indicate that inhibiting CDK5 might suppress cancer cell proliferation and migration, showing promise as a target for cancer therapy.
CDK5 inhibition can impact synaptic plasticity positively, potentially enhancing memory formation and cognition.
CDK5 is primarily active in post-mitotic neurons, unlike other CDKs that function during the cell cycle. Its activity is modulated by binding to non-cyclin proteins like p35 or p39.
Yes, preclinical studies have shown promising results in animal models, indicating the potential efficacy of CDK5 inhibitors in slowing disease progression.
Customer Reviews (3)
Write a reviewIts high quality greatly enhances the reliability and reproducibility of experimental data.
Whether I need expertise in experimental optimization or troubleshooting, I can rely on the manufacturer's support to promptly address any concerns or queries.
CDK5 protein is known for its versatility and functionality, enabling researchers to explore various biological processes and molecular interactions.
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