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DAAM1

  • Official Full Name

    dishevelled associated activator of morphogenesis 1

  • Overview

    Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.
  • Synonyms

    DAAM1; dishevelled associated activator of morphogenesis 1; disheveled-associated activator of morphogenesis 1; KIAA0666; FLJ41657;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DAAM1-2312H Recombinant Human DAAM1 Protein, GST-tagged Wheat Germ GST
Human DAAM1-11811H Recombinant Human DAAM1, GST-tagged E.coli GST 715-1068a.a.
Human DAAM1-2111HCL Recombinant Human DAAM1 cell lysate N/A
Human DAAM1-989H Recombinant Human DAAM1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DAAM1-671H Recombinant Human DAAM1 Protein, His-tagged E.coli His Met1~Tyr250
Human DAAM1-1134HFL Recombinant Full Length Human DAAM1 Protein, C-Flag-tagged Mammalian cells Flag
Human DAAM1-2226H Recombinant Human DAAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DAAM1-713H Recombinant Human DAAM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DAAM1-713H-B Recombinant Human DAAM1 Protein Pre-coupled Magnetic Beads HEK293
Mouse DAAM1-4284M Recombinant Mouse DAAM1 Protein Mammalian Cell His
Mouse DAAM1-2189M Recombinant Mouse DAAM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Daam1-2444M Recombinant Mouse Daam1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DAAM1-2189M-B Recombinant Mouse DAAM1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DAAM1-1172R Recombinant Rhesus monkey DAAM1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DAAM1-997R-B Recombinant Rhesus Macaque DAAM1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DAAM1-997R Recombinant Rhesus Macaque DAAM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken DAAM1-4121C Recombinant Chicken DAAM1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DAAM1 involved in several pathways and played different roles in them. We selected most pathways DAAM1 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwayCSNK1A1L;BTRC;VANGL1;FZD7A;DKK1B;MAPK8;TRP53;WNT2BA;TP53

DAAM1 has several biochemical functions, for example, Rho GTPase binding, actin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAAM1 itself. We selected most functions DAAM1 had, and list some proteins which have the same functions with DAAM1. You can find most of the proteins on our site.

Function Related Protein
Rho GTPase bindingDIAPH1;DAPK3;DIAP3;INF2;CDC42BPB;ROCK2B;DIAPH3;ROCK2;ANTXR2A
actin bindingPAWR;PHACTR3;ABLIM1;MKL1B;CAPGB;MARCKSL1;ITGB1;PXK;LCP1
identical protein bindingPKD2L1;CXADR;TPCN1;SNX1;HSPB1;ROBO1;BNIP3L;CORO1B;SP100
protein bindingFBXL15;TRP53;CFI;HSPA4;BEX5;PRIMPOL;ID1;GNAI3;CRY1A

DAAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAAM1.

RHOA; SRC; TRIP10; FNBP1L; DVL1; RHOD; RHOC; RHOB; a5j090_xenla

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