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DPP4

  • Official Full Name

    dipeptidyl-peptidase 4

  • Overview

    The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]
  • Synonyms

    DPP4; dipeptidyl-peptidase 4; CD26; ADABP; ADCP2; DPPIV; TP103; dipeptidyl peptidase 4; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2);

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • Zebrafish
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Hi-5 Inscet Cell
  • Hi-5 Insect Cell
  • Human
  • Human Cell
  • Human Placenta
  • In Vitro Cell Free System
  • Insect cell
  • Mammalian Cell
  • Mammalian cells
  • S.frugiperda
  • Wheat Germ
  • C
  • hIgG
  • His
  • Fc
  • Flag
  • GST
  • HIS
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • hFc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DPP4-215H Active Recombinant Human DPP4 protein, His-tagged E.coli His
Human DPP4-8313H Active Recombinant Human DPP4, His tagged Hi-5 Insect Cell His
Human DPP4-1081H Active Recombinant Human DPP4, His-tagged Human HIS
Human DPP4-31H Active Native Human DPP4 Human Placenta N/A
Human DPP4-270H Active Recombinant Human DPP4 protein HEK293 N/A Asn29-Pro766
Human DPP4-116H Recombinant Human DPP4 Protein, His-tagged Insect cell His
Human DPP4-4760H Active Recombinant Human DPP4 protein, His-tagged HEK293 His Asp 34 - Pro 766
Human DPP4-134H Recombinant Human DPP4 Mammalian Cell His
Human DPP4-2844H Recombinant Human DPP4 Protein Wheat Germ N/A
Human DPP4-269H Active Recombinant Human DPP4 protein(Asn29-Pro766), hFc-tagged HEK293 N-hFc Asn29-Pro766
Human DPP4-2845H Recombinant Human DPP4 Protein, GST-tagged Wheat Germ GST
Human DPP4-27111TH Recombinant Human DPP4, His-tagged Hi-5 Inscet Cell His
Human DPP4-7872H Recombinant Human DPP4 protein, His-tagged E.coli His Ser484~Val728
Human DPP4-3739H Human 1PFQ N/A
Human DPP4-752H Recombinant Human Dipeptidyl-peptidase 4, His-tagged S.frugiperda N/A
Human DPP4-27255TH Recombinant Human DPP4, His-tagged His
Human DPP4-2979HCL Recombinant Human DPP4 cell lysate Human Cell N/A
Human DPP4-040H Recombinant Human DPP4 Protein, His-tagged CHO His 29-766
Human DPP4-4118HF Recombinant Full Length Human DPP4 Protein In Vitro Cell Free System 92 amino acids
Human DPP4-2540H Recombinant Human DPP4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DPP4-783H Recombinant Human DPP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DPP4-797HFL Recombinant Full Length Human DPP4 Protein, C-Flag-tagged Mammalian cells Flag
Human DPP4-793H Recombinant Human DPP4 Protein HEK293 766
Human DPP4-5830H Recombinant Human DPP4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DPP4-10H Active Recombinant Human DPP4 Protein (29-766aa), C-hIgG-tagged HEK293 C-hIgG 29-766 aa
Human DPP4-203H Recombinant Human DPP4 Protein, Fc-tagged HEK293 Fc 766
Human DPP48763H Recombinant Human DPP4 (39-766) Protein
Human DPP4-608H Active Recombinant Human DPP4 Protein, His-tagged CHO His 29-766
Human DPP4-197H Native Human Dipeptidyl Peptidase IV Human Placenta N/A
Human DPP4-792H Recombinant Human DPP4 Protein, His-tagged HEK293 His 766
Human DPP4-4125HF Recombinant Full Length Human DPP4 Protein, GST-tagged In Vitro Cell Free System GST 766 amino acids
Human DPP4-783H-B Recombinant Human DPP4 Protein Pre-coupled Magnetic Beads HEK293
Human DPP4-1494H Recombinant Human DPP4 Protein (Thr401-Thr746), N-His tagged E.coli N-His Thr401-Thr746
Human DPP4-4063H Recombinant Human DPP4 protein(Asn29-Pro766), C-His-tagged HEK293 C-His Asn29-Pro766
Mouse Dpp4-413M Active Recombinant Mouse Dipeptidylpeptidase 4, His-tagged Mammalian cells His
Mouse Dpp4-7873M Recombinant Mouse Dpp4 protein, His-tagged E.coli His Ser29~Arg178 (Accession # P28843)
Mouse Dpp4-120M Recombinant Mouse Dpp4, Fc-tagged Human Cell Fc
Mouse Dpp4-7874M Recombinant Mouse Dpp4 protein, His-tagged E.coli His Ser631~His760 (Accession # P28843)
Mouse Dpp4-415M Active Recombinant Mouse DPP4 protein, His-tagged HEK293 His Ser29-His760
Mouse DPP4-4794M Recombinant Mouse DPP4 Protein Mammalian Cell His
Mouse Dpp4-2641M Recombinant Mouse Dpp4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Dpp4-2369M Recombinant Mouse Dpp4 protein, His-SUMO-tagged E.coli His-SUMO 29-760aa
Mouse Dpp4-2503M-B Recombinant Mouse Dpp4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Dpp4-2503M Recombinant Mouse Dpp4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DPP4-1943R Recombinant Rat DPP4 Protein Mammalian Cell His
Rat Dpp4-7875R Recombinant Rat Dpp4 protein, His-tagged E.coli His Ser638~Arg767 (Accession # P14740)
Rat DPP4-1602R Recombinant Rat DPP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Dpp4-2370R Recombinant Rat Dpp4 protein, His-tagged E.coli His 37-767aa
Rat DPP4-1602R-B Recombinant Rat DPP4 Protein Pre-coupled Magnetic Beads HEK293
Rat Dpp4-2823R Recombinant Rat Dpp4 protein, His-SUMO-tagged E.coli His-SUMO 638-767aa
Bos taurus (Bovine) RFL19301BF Recombinant Full Length Bovine Dipeptidyl Peptidase 4(Dpp4) Protein, His-Tagged E.coli expression system His Full Length (1-765)
Cynomolgus DPP4-1203C Active Recombinant Cynomolgus DPP4 protein, His-tagged HEK293 His Asn29-Pro766
Cynomolgus Monkey DPP4-119C Active Recombinant Cynomolgus DPP4, Fc-tagged Human Cell Fc
Cynomolgus Monkey DPP4-95C Recombinant Cynomolgus DPP4, Fc tagged Human Cell N/A
Cynomolgus Monkey DPP4-201C Recombinant Cynomolgus DPP4 Human Cell N/A Asp34-Pro766
Cynomolgus Monkey DPP4-733CCL Recombinant Cynomolgus DPP4 cell lysate Human Cell N/A
Homo sapiens (Human) RFL31481HF Recombinant Full Length Human Dipeptidyl Peptidase 4(Dpp4) Protein, His-Tagged E.coli expression system His Full Length (1-766)
Rhesus Macaque DPP4-1323R Recombinant Rhesus monkey DPP4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DPP4-1148R-B Recombinant Rhesus Macaque DPP4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DPP4-1148R Recombinant Rhesus Macaque DPP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sus scrofa (Pig) RFL8847SF Recombinant Full Length Pig Dipeptidyl Peptidase 4(Dpp4) Protein, His-Tagged E.coli expression system His Full Length (1-766)
Zebrafish DPP4-7484Z Recombinant Zebrafish DPP4 Mammalian Cell His
Chicken DPP4-2913C Recombinant Chicken DPP4 Mammalian Cell His
Kit-0313 DPP IV Immunocapture Activity Assay Kit N/A
Kit-0312 Dipeptidyl peptidase IV Inhibitor Screening Assay Kit N/A
Kit-0315 DPP4 Inhibitor Screening Kit N/A
Kit-0314 DPP4 Activity Fluorometric Assay Kit N/A
Kit-0317 DPPIV/CD26 Assay Kit N/A
Kit-0316 DPPIV drug discovery Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DPP4 Related Articles
  • DPP4 Related Research Area

DPP4 involved in several pathways and played different roles in them. We selected most pathways DPP4 participated on our site, such as Incretin synthesis, secretion, and inactivation, Metabolism of proteins, Peptide hormone metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Incretin synthesis, secretion, and inactivationO3far1;DPP4;GPR120;CDX2;GRP;PCSK1;SPCS3;GPR119;SLC38A8
Metabolism of proteinsPROZ;HYOU1;TIMM13;CALCA;SEC16B;SCFD1;CPA3;HDGF;SEC22A
Peptide hormone metabolismCMA1;ACE;BCHE;SLC30A6;CPN1;SLC38A8;INHA;CPB2;GRP
Protein digestion and absorptionPGA5;CPA3;MEP1B;SLC15A1;CELA2A;CPA2;SLC9A3;ATP1B4;CELA2B
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)GPR119;PCSK1;DPP4

DPP4 has several biochemical functions, for example, dipeptidyl-peptidase activity, identical protein binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPP4 itself. We selected most functions DPP4 had, and list some proteins which have the same functions with DPP4. You can find most of the proteins on our site.

Function Related Protein
dipeptidyl-peptidase activityDPEP3;DPP7;FAP;DPP4;NAALAD2;DPEP2;DPP8;DPP3;DPEP1
identical protein bindingCXADR;C14orf166;WAS;ALCAMA;CREBZF;RUVBL2;ACY3;CEP72;PRKAB2
protease bindingUBC;ITGB1;CD70;PINK1;ECM1;F3;INS2;SRI;Serpina1c
protein bindingASPA;B2M;ELF4;TNNI3;CCDC155;EZR;CEP70;SEPT3;UBE2D3
protein homodimerization activityGPD1C;ADAM10;CHUK;HIF1AN;TPD52L1;SLIT2;SLC11A1;TENM1;NOG
receptor bindingCALCA;PTK6B;NSG1;PECI;TNFSF9;SLC27A2;FLT3LG;PDGFRB;CAV1
serine-type endopeptidase activityF7;C1RL;PRSS12;PCSK5;PRSS59.2;CFB;PARLA;GZME;GM5077
serine-type peptidase activityDPP6;DPP7;GZMM;MCPT1;ZFYVE9;GZME;KEX2;PRSS44;HTRA1A
virus receptor activitySLC20A2;SERPINB4;TYRO3;EFNB2;CD46;CR2;AXL;PVRL1;CLEC4G

DPP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPP4.

CXCL11; CXCL10; CXCL2; CCL11; CXCL9

Gierer, S; Muller, MA; et al. Inhibition of Proprotein Convertases Abrogates Processing of the Middle Eastern Respiratory Syndrome Coronavirus Spike Protein in Infected Cells but Does Not Reduce Viral Infectivity. JOURNAL OF INFECTIOUS DISEASES 211:889-897(2015).
Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does DPP4 relate to diabetes? 04/17/2023

DPP4 plays a crucial role in glucose homeostasis by cleaving incretin hormones. In diabetes, inhibiting DPP4 can enhance the action of these hormones, promoting insulin release and lowering blood sugar levels.

Are there any side effects associated with DPP4 inhibitors? 01/11/2022

Common side effects of DPP4 inhibitors include respiratory and urinary tract infections, headache, and nasopharyngitis. However, they are generally well-tolerated.

What clinical applications does DPP4 have in managing type 2 diabetes? 06/12/2020

Inhibitors of DPP4 are used in the treatment of type 2 diabetes to improve glycemic control. They work by prolonging the activity of incretin hormones, such as GLP-1, which stimulate insulin secretion.

Can DPP4 inhibitors be used as a monotherapy for diabetes? 03/10/2020

DPP4 inhibitors are often used as monotherapy or in combination with other antidiabetic medications to achieve optimal glycemic control.

How do DPP4 inhibitors differ from other diabetes medications? 06/11/2016

DPP4 inhibitors work by enhancing the effects of incretin hormones, while other diabetes medications may act on insulin sensitivity, insulin release, or glucose absorption.

Customer Reviews (3)

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Reviews
09/13/2019

    Its purity and efficacy make it an ideal choice for precise and accurate analysis, allowing me to generate reliable results.

    01/27/2019

      By incorporating the DPP4 Protein into their studies, scientists can confidently conduct their research, ushering in groundbreaking discoveries and novel insights within their respective domains.

      12/14/2016

        Its exceptional purity and functionality make it an ideal choice for accurate and precise analysis, ensuring reliable and reproducible results.

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