FGB
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Official Full Name
fibrinogen beta chain
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Overview
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. -
Synonyms
FGB; fibrinogen beta chain; fibrinogen, B beta polypeptide; MGC104327; MGC120405;
- Transfected Stable Cell Lines
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Cattle
- Chicken
- Dog
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Zebrafish
- Bovine Plasma
- Dog Plasma
- E.coli
- HEK293
- Human plasma
- Mammalian Cell
- Porcine plasma
- Rabbit Plasma
- Rat plasma
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|S
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- FGB Related Articles
- FGB Related Research Area
FGB involved in several pathways and played different roles in them. We selected most pathways FGB participated on our site, such as Complement and coagulation cascades, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Complement and coagulation cascades | C2;C7;Hc;MASP1;C5;VWF;CD59;F12;F7 |
Platelet activation | PIK3R1;MYLK3;PRKG2;COL24A1;ITPR3;MAPK3;P2RY1;PIK3CD;PIK3R5 |
FGB has several biochemical functions, for example, contributes_to cell adhesion molecule binding, chaperone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGB itself. We selected most functions FGB had, and list some proteins which have the same functions with FGB. You can find most of the proteins on our site.
Function | Related Protein |
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contributes_to cell adhesion molecule binding | FGA;FGB |
chaperone binding | HSPE1;DNAJA3A;DNAJB4;VWF;AHSA2;DNAJB5;ATP1A2;BAG4;SYVN1 |
protein binding | SLC8A1;INO80E;SLC6A12;DDR1;ALKBH8;MARCH2;OAS1B;SHC3;DTX2 |
protein binding, bridging | RAD50;GOLGA5;CNTLN;NMD3;BCL3;COL1A2;FRMD4A;ANK2;DSP |
contributes_to receptor binding | FGA;FGB |
structural molecule activity | CLDN12;TUBA1C;LCE1F;NES;LAD1;CLTA;PRPH;CLDN8;LCE4A |
FGB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGB here. Most of them are supplied by our site. Hope this information will be useful for your research of FGB.
FGA; p27958-pro_0000037566; KLK6; MIS12; GAMMAHV.ORF10; TK1; ANXA7; p29991-pro_0000037940; p29991-pro_0000308465; CDKN1A; CSNK2B; BKLF1; AIMP2; GRB7; SMN1; PIK3R3
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, congenital fibrinogen disorders, such as afibrinogenemia and hypofibrinogenemia, are genetic disorders characterized by deficient or low FGB protein levels.
Low FGB protein levels can result in impaired blood clotting, leading to an increased risk of bleeding and hemorrhage.
High FGB protein levels can be associated with conditions such as inflammation, infection, and certain cancers.
FGB protein levels can be measured to assess the risk of thrombosis or bleeding in patients with coagulation disorders.
Conditions such as liver disease, DIC (disseminated intravascular coagulation), and certain genetic disorders can lead to decreased FGB protein levels.
Customer Reviews (3)
Write a reviewTheir team of experts has been instrumental in addressing any issues or concerns I have encountered during my experiments.
The FGB Protein boasts remarkable stability, ensuring its integrity is maintained during storage and experimentation.
Equally noteworthy is the remarkable technical support provided by the manufacturer.
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