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GP6

  • Official Full Name

    glycoprotein VI (platelet)

  • Overview

    This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor;for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded;protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon;collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively;spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms

    GP6; glycoprotein VI (platelet); platelet glycoprotein VI; GPVI; Glycoprotein VI; GPIV; MGC138168; Platelet collagen receptor; Platelet glycoprotein VI precursor; glycoprotein 6; BDPLT11;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • E.coli
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian cells
  • C
  • FC
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GP6-5623H Active Recombinant Human Glycoprotein 6 (platelet), His-tagged Mammalian cells His
Human GP6-1950H Recombinant Human GP6 protein, His-tagged E.coli His Tyr86~Thr231 (Accession # Q9HCN6)
Human GP6-5821HCL Recombinant Human GP6 293 Cell Lysate HEK293 N/A
Human GP6-3054H Recombinant Human GP6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GP6-3054H-B Recombinant Human GP6 Protein Pre-coupled Magnetic Beads HEK293
Human GP6-2689H Recombinant Human GP6 Protein (Ser22-Thr203), C-FC tagged Mammalian cells C-FC Ser22-Thr203
Mouse Gp6-5622M Active Recombinant Mouse Glycoprotein 6 (platelet), His-tagged Mammalian cells His
Mouse Gp6-361M Active Recombinant Mouse Gp6, His-tagged Mammalian cells His
Mouse Gp6-3808M-B Recombinant Mouse Gp6 Protein Pre-coupled Magnetic Beads HEK293
Mouse Gp6-360M Recombinant Mouse Gp6(Gln22-Lys265) Protein, C-6*His-tagged HEK293 His
Mouse Gp6-2985M Recombinant Mouse Gp6 protein, His-SUMO-tagged E.coli His-SUMO 22-265aa
Mouse Gp6-3808M Recombinant Mouse Gp6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
E.coli GP6-2611M Recombinant Mouse GP6 Protein (22-265 aa), His-SUMO-tagged E.coli His/SUMO 22-265 aa
Mus musculus (Mouse) RFL2769MF Recombinant Full Length Mouse Platelet Glycoprotein Vi(Gp6) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-313)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GP6 Related Articles
  • GP6 Related Research Area

GP6 involved in several pathways and played different roles in them. We selected most pathways GP6 participated on our site, such as ECM-receptor interaction, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ECM-receptor interactionCOL6A3;ITGA6B;COL1A1B;Itga10&Itgb1;ITGA9;THBS2;COL27A1B;GP9;ITGA1
Platelet activationPPP1R12A;PLCG2;AKT2;RAP1A;FERMT3;FGB;VWF;ARHGEF12;VASP

GP6 has several biochemical functions, for example, collagen binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GP6 itself. We selected most functions GP6 had, and list some proteins which have the same functions with GP6. You can find most of the proteins on our site.

Function Related Protein
collagen bindingMTAP1A;GP6;CTSK;Pdgfa&Pdgfb;RELL2;ANTXR1;ASPN;ABI3BP;DDR1
protein bindingC20orf20;RAB3C;PFKL;CSRP2;OSBPL7;DTX2;BID;SOX10;POR
receptor activityNLGN2A;PAQR5A;TNFRSF9;CD86;OGFRL2;CD33;ITGB1B.1;CD200;CMKLR1
transmembrane signaling receptor activityBCAM;LGR5;FCGR2C;KIR2DL4;OR4F29;CD79A;GP6;CD69;TLR7

GP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GP6.

CALM1; FYN; YES1; LYN; FCER1G

Hassapis, KA; Stylianou, DC; et al. Architectural Insight into Inovirus-Associated Vectors (IAVs) and Development of IAV-Based Vaccines Inducing Humoral and Cellular Responses: Implications in HIV-1 Vaccines. VIRUSES-BASEL 6:5047-5076(2014).
Guo, FC; Liu, Y; et al. Human Papillomavirus Infection and Esophageal Squamous Cell Carcinoma: A Case-Control Study. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 21:780-785(2012).
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