HLA-DRB1
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Official Full Name
major histocompatibility complex, class II, DR beta 1
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Overview
The MHC molecule provides a context for the recognition of antigens by T lymphocytes. HLA-DR13 is associated with resistance to hepatitis B virus infection. -
Synonyms
HLA DRB1; MHC class II antigen HLA DR13; HLA DR13; major histocompatibility complex, class II, DR beta 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Homo sapiens (Human)
- Human
- Mouse
- E.coli
- E.coli expression system
- HEK293T
- Human Cell
- Insect Cell
- Fc
- GST
- His
- His|SUMO|Myc
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- HLA-DRB1 Related Articles
HLA-DRB1 involved in several pathways and played different roles in them. We selected most pathways HLA-DRB1 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | ITGB2;ITGB1;C1RA;ACTB2;RAB5C;BLB2;Itgam&Itgb2;BF1;ATP6AP1 |
| Cell adhesion molecules (CAMs) | CLDN11B;VTCN1;Icosl;CLDNA;F11R.1;HLA-DOB;SDC3;BLB2;SDC2 |
| Antigen processing and presentation | CD4;HSPA5;TNF;HLA-F;HSPA1A;HLA-DRB4;HLA-DMB;KIR2DS5;NFYB |
| Hematopoietic cell lineage | HLA-DRB1;IL4;IL5;ITGA2;CD33;CR1;IL11RA;CD8B;CD22 |
| Intestinal i | TNFRSF13B;LTBR;HLA-DMA;MHC2DAB;BMA1;HLA-DRB1;CXCL12;BLA;MAP3K14 |
| ne network for IgA production | BLB1;HLA-DRB4;IL15RA;HLA-DRB1;CCR9A;IL15;MADCAM1;HLA-DRB3;TGFB1 |
| Type I diabetes mellitus | H2-Q10;IL12B;PRF1;PTPRN2;LTA;TNF;Fasl;HLA-DRB4;HLA-B |
| Leishmaniasis | IL12B;ELK1;H2-AB1;TLR2;MARCKSL1;MAPK1;ITGB2;HLA-DMA;IL1B |
| Toxoplasmosis | AKT2;NOS2;IRAK4;LAMC1;HLA-DMB;PIK3CD;MYD88;LAMC2;HLA-DQA2 |
| Staphylococcus aureus infection | FPR3;C3;C2;C4A;HLA-DMB;C1S;HLA-DOB;HLA-DQB1;ITGB2 |
| Tuberculosis | PPP3R1;Il23a; Il12b;TNF;ATP6AP1;CARD9;PPP3CC;MAPK10;IFNA14;CD209C |
| Influenza A | TMPRSS2;CYCS;TMPRSS13;NFKBIB;IFNA5;TYK2;CCL5;CXCL10;H2-AA |
| HTLV-I infection | DLG1;KAT2B;FZD2;TP53INP1;SMAD3;NFYB;ATF4;PIK3R2;IL15 |
| Herpes simplex infection | CSNK2A2;SRSF5A;TLR9;MAP3K7;SRSF1B;IFIH1;TLR2-2;IL12BA;MAVS |
| Epstein-Barr virus infection | YWHAZ;Fcer2a;TRAF2;RBPJL;PSMC4;SKP2;PSMC2;POLR2K;IKBKB |
| Asthma | RNASE3;IL5;CD40LG;EPX;HLA-DQA2;IL4;MS4A2;HLA-DRB4;CCL11 |
| Autoi | IFNA13;HLA-DMB;HLA-DPB1;TSHB;GZMB;IFNA7;HLA-DRA;CD80;IFNA8 |
| ne thyroid disease | PRF1;HLA-DMA;HLA-DQB1;IFNA2;HLA-DOB;Fasl;HLA-C;FAS;IFNA1 |
| Inflammatory bowel disease (IBD) | IL21;STAT6;IL13;HLA-DPB1;HLA-DRB3;IL6;HLA-DPA1;IL22;FOXP3 |
| Systemic lupus erythematosus | C1QC;ACTN3;H2AFB2;C9;H2AFY;HIST1H4N;GRIN2B;HIST1H4H;HIST1H2BK |
| Rheumatoid arthritis | ATP6V0C;TLR2;CXCL5;HLA-DPB1;HLA-DRA;MMP1A;HLA-DMB;HLA-DRB3;CD86 |
| Allograft rejection | HLA-G;HLA-DRA;H2-AA;FAS;Il2;CD40;H2-Q10;HLA-DQA1;IL12B |
| Graft-versus-host disease | HLA-DRA;KLRD1;FASLG;HLA-DPA1;CD28;HLA-DQA2;HLA-DMA;HLA-C;HLA-DQA1 |
| Viral myocarditis | CAV1;HLA-DRB5;HLA-DRB1;EIF4G2;ACTB;HLA-DQB1;H2-AA;Casp3;RAC1 |
HLA-DRB1 has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRB1 itself. We selected most functions HLA-DRB1 had, and list some proteins which have the same functions with HLA-DRB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class II protein complex binding | MS4A1;ANXA11;PKM;HLA-DRA;ATP1B1;CD74;YWHAE;HSP90AA1;CD81 |
| MHC class II receptor activity | HLA-DRB4;HLA-DPA1;KRT17;HLA-DOA;HLA-DRA;HLA-DOB;HLA-DQB2;HLA-DRB1;HLA-DRB3 |
| peptide antigen binding | MAML1;MHC1UDA;CD209;MHC1UIA;MHC1ZKA;HLA-DRB4;MHC1ZDA;H2-Q10;MHC1UFA |
| virus receptor activity | GYPA;CXADR;HLA-DRB1;CLDN1;CLEC4G;CD4;CD209;CD46;IDE |
HLA-DRB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRB1.
HLA-DMA
- Q&As
- Reviews
Q&As (7)
Ask a questionHLA-DRB1 alleles are linked to susceptibility and progression of various diseases.
Certain HLA-DRB1 alleles are associated with a higher risk of autoimmune diseases.
Variability in HLA-DRB1 can affect transplant success, with mismatches potentially leading to rejection.
Its expression is tightly controlled, influenced by cytokines and immune signals.
It binds peptides from extracellular proteins, presenting them on the cell surface for T cell recognition.
HLA-DRB1 is crucial for immune responses, presenting peptides to CD4+ T cells.
Therapeutic strategies might involve modulating HLA-DRB1 expression or function in autoimmune diseases or transplantation.
Customer Reviews (3)
Write a reviewConsistently good quality.
Great product, fast shipping.
Excellent quality, very pure.
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