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TAC3

Official Full Name

tachykinin 3
Overview

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily;expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand;for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may;be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with;normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants.
Synonyms

TAC3; tachykinin 3; neurokinin beta , neuromedin K , NKNB; tachykinin-3; NKB; ZNEUROK1; neuromedin K; gamma tachykinin 3; preprotachykinin B; NKNB; PRO1155;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Rat

Source

E.coli
HEK293
HEK293T

Tag

GST
His
His|GST
Myc
DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TAC3-3093H	Recombinant Human TAC3, GST-tagged	E.coli	GST	1-121aa	$319 / 25ug
Human	TAC3-79H	Recombinant Human Tachykinin 3, His-tagged	E.coli	His		Inquiry
Human	TAC3-29652TH	Recombinant Human TAC3, His-tagged	E.coli	His	105 amino acids	Inquiry
Human	TAC3-29653TH	Recombinant Human TAC3, His-tagged	E.coli	His		Inquiry
Human	TAC3-1287HCL	Recombinant Human TAC3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TAC3-6390H	Recombinant Human TAC3 Protein (Cys23-Glu121), N-His tagged	E.coli	N-His	Cys23-Glu121	Inquiry
Human	TAC3-4009H	Recombinant Human TAC3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Rat	Tac3-5805R	Recombinant Rat Tac3 protein, His & GST-tagged	E.coli	His/GST	Gln29~Ala102 (Accession # P08435)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
TAC3 Related Articles

TAC3 involved in several pathways and played different roles in them. We selected most pathways TAC3 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)	ADRB2;GPR18;NMBB;GPR65;MLN;PYY;CXCL13;AMCF-II;OXGR1A.1
G alpha (q) signalling events	UTS2D;ANXA1;FFAR3;NMB;TRH;NMU;NPS;HCRT;MGLL
GPCR downstream signaling	CHRM3;ARHGEF18;LPAR2B;TAS2R16;NTS;KALRN;OPN1MW2;PENK;ADM2
GPCR ligand binding	RCA2.1;NPSR1;RLN3A;CX3CR1;CHRM4;PMCH;GPR37L1;GPR39;LPAR2A
Gastrin-CREB signalling pathway via PKC and MAPK	LPAR5A;PROK2;NMU;FPR-RS3;DGKB;NPFF;DGKQ;EDNRAB;FPR-RS4
Peptide ligand-binding receptors	CXCL11.8;SST1.1;PENKB;PROKR1A;CCL27;RLN3A;OXTRL;SSTR5;PRLH
Signal Transduction	OPN4;CCL35.2;FSTL1;AATF;CRABP1B;BOC;MDK;UTS2;RGS4
Signaling by GPCR	TRH;TAC2;ARHGEF25;GPR55;RGS18;EMR4;TAC3;ZFPM2B;ADCYAP1B

TAC3 has several biochemical functions, for example, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAC3 itself. We selected most functions TAC3 had, and list some proteins which have the same functions with TAC3. You can find most of the proteins on our site.

Function	Related Protein
protein binding	PSMC4;C7orf59;CCDC64;MAGEB4;WBP2NL;SMIM3;ROBO1;RIN1;FYN
receptor binding	PVRL1A;GRIN2A;LAMA3;INSL4;FGF24;SEMA4D;PVRL2;LIF;CRH

TAC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAC3.

IKBKAP; PTN; UBR1; VOPP1; FEZ1; CCDC90B

Bahadory, F; Moore, KH; et al. Gene expression of nnuscarinic, tachykinin, and purinergic receptors in porcine bladder: comparison with cultured cells. FRONTIERS IN PHARMACOLOGY 4:-(2013).

Mostafa, GA; Al-Ayadhi, LY; et al. The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism. JOURNAL OF NEUROINFLAMMATION 8:-(2011).