VEGFC
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Official Full Name
vascular endothelial growth factor C
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Overview
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014] -
Synonyms
VEGFC; vascular endothelial growth factor C; VRP; Flt4-L; FLT4 ligand DHM; vascular endothelial growth factor-related protein; VEGF-C; AW228853;
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- VEGFC Related Articles
Fig1. Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib and cilengitide are known to act. (Pictures from PHARMGKB)
What is VEGFC protein?
VEGFC (vascular endothelial growth factor C) gene is a protein coding gene which situated on the long arm of chromosome 4 at locus 4q34. The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. The VEGFC protein is consisted of 419 amino acids and its molecular mass is approximately 46.9 kDa.
What is the function of VEGFC protein?
VEGFC act as a growth factor in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. It may has functions in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults.
VEGFC Related Signaling Pathway
The VEGFR-2/3 signaling pathway, when combined with it, can activate the pathway, thereby promoting lymphangiogenesis and tumor metastasis. In the PI3K/Akt signaling pathway, VEGFC activates phosphatidylinositol 3-kinase (PI3K) through VEGFR-2, and then activates Akt, which is involved in the regulation of cell proliferation, survival and vascular permeability. In addition, there are MAPK/ERK signaling pathways, Notch signaling pathways and so on.
VEGFC Related Diseases
Overexpression of VEGFC is associated with angiogenesis and metastasis of malignant tumors, such as breast cancer, lung cancer, and colorectal cancer. It is also associated with lymphangiogenesis and lymph node metastasis, and overexpression of VEGFC can lead to abnormal lymphangiogenesis and lymph node enlargement. In addition, some other vascular diseases are associated, such as generalized vasodilatation, congenital lymphedema and so on.
Fig2. Expression patterns determining different types of metastases in EOC Tumour cells of patients with 'predominant retroperitoneal' metastases are characterised by a mesenchymal tumour type with low E-Cadherin and high VEGF-C and –D expression. (Sascha Kuerti, 2017)
Bioapplications of VEGFC
Using VEGFC's anti-angiogenic effect, researchers are exploring its use in the treatment of tumors, inhibiting tumor angiogenesis and stopping tumor growth and metastasis. At the same time, there are also some studies on the treatment of cardiovascular diseases such as myocardial infarction and arterial disease.
High Purity
Fig1. SDS-PAGE (VEGFC-604H) (PROTOCOL for western blot)
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Fig2. Activity Data. (VEGFC-566H)
Case Study 1: Omar García-Pérez, 2023
Fig1. VEGFC protein in CSCC tumors detected by immunofluorescence.
Case Study 2: Zhengmin Wang, 2021
Fig2. Various VEGF-positive bands in the GBM cell lysates were detected by pan-VEGF antibody, and the molecular weight ranged from 15 to 120 kDa.
Fig2. Blocking VEGF-C signaling reduces immune cells infiltration to endometriotic tissues. (Wan-Ning Li, 2020)
VEGFC involved in several pathways and played different roles in them. We selected most pathways VEGFC participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with VEGFC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ras signaling pathway | PLA2G4C;CALM1;PDGFRB;TBK1;SHC2;CALM2;VEGFC;PLCG2;PLCG1 |
Rap signaling pathway | PIK3R1;FIGF;SRC;VASP;NGFR;VEGFB;FLT4;FGF5;FGF12 |
Cytokine-cytokine receptor interaction | PF4V1;IL2RGB;RNF207B;CTF1;IL4R;KDR;CCR1;CNTFR;CXCL3 |
PIK-Akt signaling pathway | VEGFC;PDGFA;HSP90AA1;RELA;ANGPT1;FGFR4;PIK3CD;FGF20;ITGB6 |
Focal adhesion | ITGA1;VEGFB;PARVAA;COMP;COL5A2;FYNA;PPP1CA;RAC3B;RHOAA |
TNF signaling pathway | RELA;MAP3K7;MMP14;IL1B;CXCL2;CASP7;MAP2K3;RPS6KA5;RPS6KA4 |
Pathways in cancer | PRKACG;RBX1;ARNT;EGLN3;DAPK2;FGF14;TCF7L2;MAPK10;FGF6 |
VEGFC has several biochemical functions, for example, chemoattractant activity, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VEGFC itself. We selected most functions VEGFC had, and list some proteins which have the same functions with VEGFC. You can find most of the proteins on our site.
Function | Related Protein |
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chemoattractant activity | SAA1;SAA3;SCG2;CXCL12;VHL;FGF2;CCL16;FIGF;HMGB2 |
growth factor activity | AREG;BMP2B;FGF3;OGN;FGF8B;IL9;TGFB1A;GSDF;FGF12A |
protein binding | KCP;KCNIP2;CAMP;IP6K2;IGFBP3;CXCL14;SNRPD3;GPRC5A;NSMCE1 |
vascular endothelial growth factor receptor 3 binding | VEGFC;FIGF;VHL |
VEGFC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VEGFC here. Most of them are supplied by our site. Hope this information will be useful for your research of VEGFC.
FLT4
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Q&As (7)
Ask a questionVEGFC primarily signals through its interactions with VEGFR-2 (Vascular Endothelial Growth Factor Receptor 2) and VEGFR-3. Upon binding to one of these receptors, VEGFC triggers receptor dimerization, leading to the activation of intracellular signaling pathways. This activation involves phosphorylation events and subsequent recruitment of downstream effectors, which ultimately regulate cellular responses such as proliferation, migration, and angiogenesis. The intricate signaling mechanisms underlying VEGFC-receptor interactions contribute to its functional versatility and provide potential targets for therapeutic interventions.
VEGFC protein is derived from the conversion of proVEGFC precursor protein and comprises approximately 354 amino acid residues. Structurally, it consists of a signal sequence, an N-terminal domain, and a C-terminal VEGF homology domain. The signal sequence is involved in cellular localization and secretion processes, while the VEGF homology domain interacts with target receptors, mediating cellular proliferation and angiogenesis. Understanding the specific structural features is crucial for elucidating the functional properties and molecular interactions associated with VEGFC.
VEGFC's involvement in pathological conditions, including cancer, is extensively studied. The upregulation of VEGFC expression in tumor cells promotes angiogenesis and lymphangiogenesis within the tumor microenvironment. This enhanced blood and lymphatic vessel formation facilitates tumor growth, invasion, and metastasis. Moreover, VEGFC can induce lymphangiogenesis in sentinel lymph nodes, aiding cancer cell dissemination. Targeting VEGFC signaling pathways has emerged as a potential therapeutic strategy to inhibit tumor angiogenesis and lymphangiogenesis, highlighting the clinical significance of understanding the complex interplay between VEGFC and cancer progression.
Several therapeutic interventions targeting VEGFC and its downstream signaling pathways are under investigation. Anti-VEGFC monoclonal antibodies, VEGFR inhibitors, and small molecule inhibitors of VEGFC-mediated signaling have shown promise in preclinical and clinical studies. These interventions aim to disrupt the angiogenic and lymphangiogenic processes driven by VEGFC, thereby inhibiting tumor growth, metastasis, and other pathological conditions associated with VEGFC dysregulation. Additionally, exploring combinational approaches with existing therapies, such as chemotherapy and immunotherapy, holds potential for synergistic effects and improved treatment outcomes. Continued research efforts are focused on optimizing these interventions for clinical application and expanding the therapeutic repertoire for VEGFC-associated diseases.
Multiple regulatory mechanisms control VEGFC expression levels. Transcriptional regulation plays a significant role, with various transcription factors binding to the VEGFC promoter region to activate or suppress its transcription. Additionally, post-transcriptional regulation through microRNAs and RNA-binding proteins can modulate VEGFC mRNA stability and translation efficiency. Furthermore, environmental factors, such as hypoxia and inflammation, influence VEGFC expression by activating specific signaling pathways. Understanding the precise regulatory mechanisms is crucial for deciphering the intricate balance required for maintaining proper VEGFC levels and ensuring its functional integrity.
Dysregulation of VEGFC has been associated with various pathological conditions. Excessive VEGFC expression has been implicated in tumor angiogenesis, promoting the growth and spread of cancer cells by stimulating the formation of blood and lymphatic vessels in the tumor microenvironment. On the other hand, decreased or insufficient VEGFC levels have been linked to lymphatic disorders, such as lymphedema, where impaired lymphatic vessel development results in fluid buildup and tissue swelling. Additionally, alterations in VEGFC signaling have been observed in ocular diseases, inflammatory disorders, and cardiovascular diseases. Understanding the dysregulation of VEGFC in these contexts may pave the way for potential therapeutic strategies targeting this protein.
VEGFC (Vascular Endothelial Growth Factor C) has diverse cellular functions. Primarily, it serves as a potent angiogenic factor, participating in neovascularization and lymphangiogenesis processes. VEGFC also regulates endothelial cell proliferation and migration, playing a crucial role in lymphatic dissemination and metastasis. Additionally, VEGFC is implicated in neurodevelopment, mammary gland morphogenesis, tissue regeneration, and other physiological processes. Its multifaceted functions highlight its significance in various biological contexts, emphasizing the need for further investigation to unravel its precise mechanisms and implications.
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Write a reviewEmbodied with the glorious power of scientific progress, the innovation behind this reagent inspires truly remarkable experimental encounters.
By requiring minimal usage, this protein reagent significantly reduces consumable costs, making it an ideal choice for large-scale experiments.
The manufacturer's proactive approach in offering valuable insights and suggestions has greatly improved the outcome of my experiments.
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