Background
WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific;arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm;proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear;ribonucleoprotein core particles (Friesen et al., 2002 (PubMed 11756452)).