ACAP3B

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Protein tags may or may not affect protein activity. For some applications, His tags may not affect protein activity and therefore need not be removed. However, protein tags are useful for affinity purification or for a variety of other purposes. If you are concerned about tags interfering with protein activity, Creative BioMart can also offer tag-free recombinant ACAP3B protein customization services.

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The interaction between ACAP3B and ARF6 is mediated by the PH domain of ACAP3B, which binds to the N-terminal helix of ARF6. This interaction results in the recruitment of ACAP3B to the plasma membrane and its subsequent activation as a GAP for ARF6. The coiled-coil domain of ACAP3B is also involved in its interaction with ARF6 and plays a role in regulating its activity.

ACAP3B is widely expressed in different tissues, with higher expression levels detected in brain, heart, and kidney tissues. It is also expressed in various cancer cell lines, suggesting its potential role in cancer development and progression.

ACAP3B has been shown to play a role in endocytosis by regulating the internalization of cell surface receptors. It interacts with the clathrin adaptor protein AP-2 and is involved in the formation of clathrin-coated pits, which are responsible for the internalization of various receptors from the cell surface.

ACAP3B is involved in cytokinesis, the final stage of cell division, by regulating the trafficking of membrane vesicles to the cleavage furrow. It interacts with the centralspindlin complex, which is required for the assembly of the contractile ring that drives cytokinesis.

ACAP3B protein is involved in membrane trafficking and vesicle formation through its interaction with the small GTPase ARF6. It acts as a GTPase-activating protein (GAP) for ARF6, which regulates membrane trafficking and fusion events in the cell.

Recombinant ACAP3B protein can be used for various applications, including biochemical assays, protein-protein interaction studies, and antibody production. Its role in membrane trafficking and vesicle formation makes it particularly useful for studying cellular processes related to endocytosis and cytokinesis.

When working with any recombinant protein, it is important to follow proper handling and safety protocols to prevent contamination and ensure safety. It is also important to consider the protein's stability and activity under the specific experimental conditions being used. Consult our instructions or seek advice from a technical support representative for guidance on handling and using recombinant ACAP3B protein.