ACCN3
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Official Full Name
amiloride-sensitive cation channel 3
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Overview
subunit that forms a proton gated Na(+) channel; may play a role in prolonged pain perception. -
Synonyms
Accn3; amiloride-sensitive cation channel 3; Asic3; DRASIC; dorsal root ASIC; acid sensing ion channel 3; acid-sensing ion channel 3; proton gated cation channel DRASIC;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Mouse | ACCN3-1176M | Recombinant Mouse ACCN3 Protein | Mammalian Cell | His | ||
Mouse | ACCN3-246M | Recombinant Mouse ACCN3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ACCN3-246M-B | Recombinant Mouse ACCN3 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
ACCN3 involved in several pathways and played different roles in them. We selected most pathways ACCN3 participated on our site, such as Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACCN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Inflammatory mediator regulation of TRP channels | CALM3;ACCN3;MAP2K6;PIK3CD;CALML5;CYP4A12A;PLA2G4D;HTR2C;PLA2G4C |
ACCN3 has several biochemical functions, for example, PDZ domain binding, cation channel activity, enterobactin transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACCN3 itself. We selected most functions ACCN3 had, and list some proteins which have the same functions with ACCN3. You can find most of the proteins on our site.
Function | Related Protein |
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PDZ domain binding | SLC22A5;LNX2;GNG12;CFTR;ATP2B1;ATP2B1A;KIF14;LIN7C;ATP2B3A |
cation channel activity | ASIC3;GAR1;FAM26D;GRIN2A;FAM26F;TRPV2;TRPM1;FAM38B;FAM38A |
enterobactin transporter activity | |
ligand-gated sodium channel activity | ASIC5;ASIC4A;ACCN5;SCNN1D;ASIC1C;ACCN3;ASIC1;ASIC1B;ASIC3 |
sodium channel activity | SLC4A11;SCN12AA;SCN4AA;KCNK1;PKD2L1;SCNN1G;ASIC4;SCN12AB;SCN8AB |
ACCN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACCN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACCN3.
- Q&As
- Reviews
Q&As (10)
Ask a questionIt may be useful for a range of applications, including biochemical and biophysical studies of its structure and function, drug screening and development targeting ACCN3, and in vitro diagnostic assays for pain or sensory disorders. The protein may also be used as an immunogen to generate specific antibodies against ACCN3 or as a standard in quantitative assays for protein detection.
Researchers employ various approaches to study ACCN3 function and regulation in experimental models. Electrophysiological techniques, such as patch-clamp recordings, allow direct measurement of ACCN3 channel activity and characterization of its biophysical properties. Pharmacological studies involve the use of specific ACCN3 agonists or antagonists to manipulate channel function and assess its physiological relevance. Genetic knockout or knockdown techniques in animal models provide valuable insights into the in vivo role of ACCN3 in sensory processing. Additionally, molecular biology and imaging techniques enable the investigation of ACCN3 expression patterns, protein-protein interactions, and intracellular signaling pathways involved in ACCN3 modulation.
ACCN3 is involved in multiple physiological processes related to sensory perception. It has been implicated in pain signaling, particularly in nociceptive neurons, where it plays a crucial role in detecting noxious stimuli. ACCN3 channels are also implicated in mechanosensation, contributing to the detection of mechanical pressure and touch. Additionally, ACCN3 participates in acid sensing, allowing neurons to respond to changes in extracellular pH.
Yes, it can serve as an immunogen to generate specific antibodies for research purposes. The suitability of the protein for antibody production would depend on factors such as its antigenicity, purity, and stability.
ACCN3 channels can be modulated by several mechanisms. One regulatory mechanism involves changes in pH: low extracellular pH can activate ACCN3 channels, leading to ion influx and cellular depolarization. ACCN3 activity can also be influenced by phosphorylation events. For example, protein kinase C (PKC) can phosphorylate ACCN3, modulating its activity. Furthermore, ACCN3 expression and function can be regulated by factors such as neuropeptides, neurotransmitters, and inflammatory mediators.
Our recombinant protein products are primarily used as a research tool and are not approved for diagnostic or therapeutic purposes.
It is essential to investigate whether ACCN3 undergoes any PTMs or has alternative splicing variants that might affect its activity or interactions. Reviewing the available literature or consulting databases such as UniProt or NCBI can provide insights into known ACCN3 PTMs or splice variants.
Certainly, protein expression can be tailored according to your research needs. Modified versions can incorporate His tags, GST tags, or other fusion partners that aid in protein purification or detection.
Yes, by using ACCN3 as a bait, proteins that physically interact with ACCN3 can be captured and subsequently identified through mass spectrometry or immunoblotting techniques. It is recommended to optimize the experimental conditions, including appropriate controls and validation steps, to ensure the specificity and reliability of the identified interactions.
Yes, and these options include protein labeling with fluorescent dyes or tags, or incorporation of specific modifications or mutations.
Customer Reviews (3)
Write a reviewI was hesitant to purchase the recombinant mouse ACCN3 protein at first, but I am glad I did. The quality was exceptional and the price was reasonable.
I had some questions about the Recombinant Mouse ACCN3 Protein before purchasing and the customer service team was quick to provide answers.
The technical support team was very helpful in assisting me with selecting the right fusion tag for the recombinant ACCN3 protein.
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