ADCK4
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Official Full Name
aarF domain containing kinase 4
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Overview
This gene encodes a protein with two copies of a domain found in protein kinases. The encoded protein has a complete protein kinase catalytic domain, and a truncated domain that contains only the active and binding sites of the protein kinase domain, however, it is not known whether the protein has any kinase activity. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ADCK4; aarF domain containing kinase 4; uncharacterized aarF domain-containing protein kinase 4; COQ8; FLJ12229;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ADCK4-428H | Recombinant Human ADCK4 Protein, His-tagged | E.coli | His | ||
Human | ADCK4-9022HCL | Recombinant Human ADCK4 293 Cell Lysate | HEK293 | N/A | ||
Rat | ADCK4-515R | Recombinant Rat ADCK4 Protein | Mammalian Cell | His | ||
Rat | ADCK4-171R | Recombinant Rat ADCK4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | ADCK4-171R-B | Recombinant Rat ADCK4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | ADCK4-240R | Recombinant Rhesus monkey ADCK4 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | ADCK4-68R-B | Recombinant Rhesus Macaque ADCK4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | ADCK4-68R | Recombinant Rhesus Macaque ADCK4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
ADCK4 involved in several pathways and played different roles in them. We selected most pathways ADCK4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ADCK4 has several biochemical functions, for example, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCK4 itself. We selected most functions ADCK4 had, and list some proteins which have the same functions with ADCK4. You can find most of the proteins on our site.
Function | Related Protein |
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protein serine/threonine kinase activity | LIMK1;CSNK1G2A;MAPK14B;BRAF;PRKCDA;SGK2;CDC42BPA;ULK3;CHEK2 |
ADCK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCK4.
Hoxa1; Kif19
- Q&As
- Reviews
Q&As (13)
Ask a questionWhile there are currently no specific drugs targeting ADCK4 protein, the regulation of the CoQ10 biosynthesis pathway and its involvement in various diseases suggest that ADCK4 protein may be a useful target for drug development. Compounds that can increase CoQ10 biosynthesis or protect against oxidative stress may be potential therapeutic agents for diseases associated with CoQ10 deficiency.
Currently, there are no clinical trials for ADCK4 protein therapy, but research is ongoing to explore the potential therapeutic applications of ADCK4 protein or the CoQ10 biosynthesis pathway. It is possible that clinical trials may be developed in the future, particularly for diseases that involve mitochondrial dysfunction.
There are currently ongoing clinical trials investigating the use of CoQ10 in the treatment of different diseases, including primary and secondary CoQ10 deficiencies, Parkinson's disease, and heart failure. However, there are no clinical trials specifically using ADCK4 protein as a treatment.
While there is currently little research on the effects of dietary interventions on ADCK4 protein levels specifically, it is known that a diet rich in fruits and vegetables, which are high in antioxidants, can help reduce oxidative stress and protect against CoQ10 deficiency. Therefore, a healthy diet may help support the function of the CoQ10 biosynthesis pathway.
While ADCK4 protein is involved in CoQ10 biosynthesis and mitochondrial function, it is not currently used as a biomarker for mitochondrial dysfunction. Other markers, such as ATP levels, mitochondrial DNA mutations, and reactive oxygen species, are more commonly used to diagnose mitochondrial dysfunction. However, research is ongoing to explore the potential use of ADCK4 protein as a biomarker.
ADCK4 protein is involved in the biosynthesis of coenzyme Q10 (CoQ10), which plays a critical role in cellular energy production and the regulation of oxidative stress. Therefore, ADCK4 protein may have potential applications in the development of new therapies for diseases associated with CoQ10 deficiency, such as primary and secondary CoQ10 deficiencies, nephrotic syndrome, and other neurological disorders.
Currently, there are no specific drugs or therapies that target ADCK4 protein, but research is ongoing to explore its potential therapeutic applications. Diseases that involve mitochondrial dysfunction, such as Parkinson's disease, may benefit from therapies that target ADCK4 protein or the CoQ10 biosynthesis pathway. However, more research is needed to understand the role of ADCK4 in these diseases.
While ADCK4 protein plays a role in cellular energy production and mitochondrial function, there is no evidence to suggest that ADCK4 protein supplementation can improve cognitive function. However, CoQ10 supplements have been studied for their potential benefits for cognitive function and neurological disorders, and further research is needed to understand the potential role of ADCK4 protein in these conditions.
There is no evidence to suggest that ADCK4 protein supplementation can improve athletic performance. While CoQ10 supplements have been studied for their potential benefits for athletes, the effects of ADCK4 protein supplementation are not yet understood.
There is currently limited research on the effects of exercise on ADCK4 protein levels specifically. However, exercise has been shown to improve mitochondrial function and reduce oxidative stress, which are important factors in the regulation of CoQ10 biosynthesis. Therefore, exercise may indirectly affect ADCK4 protein levels by improving overall mitochondrial function and reducing oxidative stress.
While CoQ10 supplementation is generally considered safe and well-tolerated, some people may experience mild side effects such as nausea, vomiting, and gastrointestinal upset. CoQ10 may also interact with certain medications, such as blood thinners and chemotherapy drugs. However, there is currently no evidence to suggest that ADCK4 protein supplementation would have any adverse side effects.
Yes, genetic testing can be used to identify mutations in the ADCK4 gene that are associated with hereditary glomerulopathies and other diseases. Genetic testing can be used to diagnose and monitor these conditions, as well as to identify carriers of ADCK4 mutations who may be at risk for passing on the mutation to their children.
There is currently no evidence to suggest that ADCK4 protein would have any cosmetic benefits. While CoQ10 is sometimes used in cosmetic products due to its antioxidant properties, it is unclear whether the addition of ADCK4 protein would have any added benefits.
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