AGPAT4
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Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
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Overview
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. -
Synonyms
AGPAT4; 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta); 1-acyl-sn-glycerol-3-phosphate acyltransferase delta; dJ473J16.2; LPAAT delta; 1 acyl sn glycerol 3 phosphate acyltransferase delta; 1 acylglycerol 3 phosphate O acyltransferase 4; 1 AGP acyltransferase 4; Lysophosphatidic acid acyltransferase delta; 1-AGPAT 4; 1-AGP acyltransferase 4; lysophosphatidic acid acyltransferase-delta (LPAAT-delta); 1-AGPAT4; LPAAT-delta; RP3-473J16.2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Mouse
- Mus musculus (Mouse)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- AGPAT4 Related Articles
AGPAT4 involved in several pathways and played different roles in them. We selected most pathways AGPAT4 participated on our site, such as Glycerolipid metabolism, Glycerophospholipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGPAT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycerolipid metabolism | ALDH2.2;ALDH9A1;LPIN3;ALDH3A2;glpK;LPIN1;MGLL;PPAP2A;ALDH1B1 |
Glycerophospholipid metabolism | LPIN2;AGPAT2;LCAT;CEPT1;EPT1;PPAP2A;MBOAT2B;PLA2G2A;PPAP2CB |
Metabolic pathways | TUSC3;ALDH3A1;CBR3;DHODH;SMPD2A;PIP5KL1;GAPDHS;ADK;PLA2G5 |
Phospholipase D signaling pathway | IL-8;PLCB1;KIT;PIK3R2;LPAR3;PIK3R3;GRB2;MAPK3;GRM7 |
AGPAT4 has several biochemical functions, for example, 1-acylglycerol-3-phosphate O-acyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGPAT4 itself. We selected most functions AGPAT4 had, and list some proteins which have the same functions with AGPAT4. You can find most of the proteins on our site.
Function | Related Protein |
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1-acylglycerol-3-phosphate O-acyltransferase activity | LPCAT2;AGPAT1;AGPAT4;AGPAT5;LCLAT1;AGPAT3;AGPAT9L;AGPAT9;AGPAT2 |
protein binding | ZNF624;ITGA2;HTN1;PSMG2;FBXL19;F12;WDYHV1;MRPL48;SH3PXD2B |
AGPAT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGPAT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGPAT4.
REL; CRK
- Q&As
- Reviews
Q&As (24)
Ask a questionAGPAT4’s function can affect cellular lipid storage and energy utilization.
Yes, AGPAT4’s activity can impact lipid-mediated signaling processes within cells.
Yes, AGPAT4’s role influences the composition and fluidity of lipid bilayers.
AGPAT4’s involvement is tied to the regulation of lipid metabolism and homeostasis.
Yes, AGPAT4’s involvement is connected to maintaining the integrity of organelle membranes.
Yes, AGPAT4’s activity is essential for the synthesis and maintenance of cellular membranes.
AGPAT4 is an enzyme involved in the biosynthesis of phospholipids and lipid metabolism.
AGPAT4’s involvement can impact the production of lipid-derived second messenger molecules.
Research investigates how AGPAT4’s dysfunction contributes to disease mechanisms.
Research investigates AGPAT4’s impact on lipid composition and profiles of cellular membranes.
Yes, AGPAT4’s function can influence the dynamics and formation of lipid droplets.
AGPAT4 catalyzes the addition of fatty acids to glycerol-3-phosphate, forming LPA.
Yes, mutations in AGPAT4 can lead to metabolic disorders affecting lipid metabolism.
Yes, AGPAT4’s activity can influence cellular growth and proliferation through lipid metabolism.
AGPAT4’s role involves generating diverse phospholipids that contribute to remodeling.
Yes, AGPAT4’s function can be influenced by cellular stress and changes in metabolic state.
Yes, AGPAT4’s activity can contribute to lipid-mediated signaling pathways within cells.
Yes, AGPAT4’s function can be modulated by intracellular signals and metabolic cues.
AGPAT4 is primarily found in the endoplasmic reticulum (ER) membrane.
Research explores how AGPAT4’s function influences cellular health and function.
Yes, AGPAT4 is a potential therapeutic target for modulating lipid metabolism and related diseases.
AGPAT4’s activity helps maintain lipid balance and cellular lipid levels.
AGPAT4’s role can influence the dynamic behavior and curvature of cellular membranes.
Yes, AGPAT4’s activity and role can vary based on the specific cellular context.
Customer Reviews (5)
Write a reviewThe comprehensive documentation streamlined the integration of the product into our experimental workflow.
The knowledge gained from the product justified its cost, offering substantial value for investment.
Replicating results emphasized the reliability and relevance of the product’s effects.
The product consistently met our expectations, lending credibility to our findings.
Comprehensive documentation streamlined our incorporation of the product into our research workflow.
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