AHI1
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Official Full Name
Abelson helper integration site 1
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Overview
Jouberin is a protein that in humans is encoded by the AHI1 gene. -
Synonyms
AHI1; Abelson helper integration site 1; jouberin; Abelson helper integration site 1 protein homolog; Abelson helper integration site; AHI 1; AHI-1; AHI1_HUMAN; Contatins SH3 and WD40 domains; dJ71N10.1; DKFZp686J1653; FLJ14023; FLJ20069; JBTS3; ORF1; OTTHUMP00000017263; OTTHUMP00000017265; OTTHUMP00000234456; OTTHUMP00000234654; OTTHUMP00000234656; abelson helper integration site 1 protein; D10Bwg0629e; 1700015F03Rik;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AHI1-459H | Recombinant Human AHI1 Protein, GST-tagged | Wheat Germ | GST | ||
Human | AHI1-41HCL | Recombinant Human AHI1 cell lysate | N/A | |||
Human | AHI1-945HF | Recombinant Full Length Human AHI1 Protein, GST-tagged | In Vitro Cell Free System | GST | 609 amino acids | |
Human | AHI1-0454H | Recombinant Human AHI1 Protein (Met1-His350), N-His-tagged | E.coli | N-His | Met1-His350 | |
Zebrafish | AHI1-4773Z | Recombinant Zebrafish AHI1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
AHI1 involved in several pathways and played different roles in them. We selected most pathways AHI1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AHI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AHI1 has several biochemical functions, for example, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHI1 itself. We selected most functions AHI1 had, and list some proteins which have the same functions with AHI1. You can find most of the proteins on our site.
Function | Related Protein |
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identical protein binding | BAIAP2;NOXO1;EED;CHAF1A;SLC22A1;VWA1;DAPK1;MAP1S;IFIT3 |
protein binding | XPO5;PAK1;PDE4D;FLVCR1;PPP2CB;VAMP8;ARL13B;BAX;NAMPT |
AHI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AHI1.
HAP1; NPHP1; DNM2; Dnm2; SMYD2; COL18A1
- Q&As
- Reviews
Q&As (10)
Ask a questionGene editing technologies like CRISPR/Cas9 hold promise for potential therapeutic interventions in AHI1-related disorders. However, further research is needed to address safety and ethical considerations.
Mouse models with AHI1 gene mutations have been widely used to study the function of the AHI1 protein and its role in ciliopathies.
AHI1 mutations disrupt ciliary transport and signaling, leading to defective cilia formation and function. These defects contribute to the pathogenesis of ciliopathies, such as Joubert syndrome.
The AHI1 protein is involved in regulating the formation and function of primary cilia, which act as sensory organelles and are essential for vesicle trafficking and cell signaling.
Techniques such as co-immunoprecipitation, yeast two-hybrid assays, and proximity-based labeling methods are commonly used to study the interactions of the AHI1 protein with other cellular proteins.
AHI1 mutations disrupt the normal function of the AHI1 protein, affecting ciliogenesis and intraflagellar transport, which are essential processes in the development of the brain's cerebellum and brainstem. This disruption leads to the characteristic features of Joubert syndrome.
AHI1 mutations have been linked to a spectrum of human disorders, including Joubert syndrome and nephronophthisis-related ciliopathies.
The AHI1 protein is known to interact with proteins involved in intraflagellar transport (IFT), such as IFT122 and IFT139, as well as other ciliary-associated proteins.
The transcription of the AHI1 gene can be influenced by various factors, including transcription factors and epigenetic modifications.
The AHI1 protein plays a critical role in various cellular processes, such as ciliogenesis, cell signaling, and vesicle trafficking.
Customer Reviews (5)
Write a reviewWe are thoroughly impressed with the proficiency of this lab protein, and it has undoubtedly elevated the caliber of our research investigations.
I'd give this protein ten stars if I could – it's that good.
This protein has made my experiments feel like a walk in the park – I highly recommend it!
Kudos to the developers of this recombination protein – it's a brilliant scientific tool.
The lab protein product has proven to be a reliable and indispensable tool in our laboratory, delivering reproducible results with utmost precision.
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