AKAP12B
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Zebrafish | AKAP12B-5656Z | Recombinant Zebrafish AKAP12B | Mammalian Cell | His | ||
Zebrafish | AKAP12B-8337Z | Recombinant Zebrafish AKAP12B | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
AKAP12B involved in several pathways and played different roles in them. We selected most pathways AKAP12B participated on our site, such as G Protein Signaling Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP12B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
G Protein Signaling Pathways | AKAP13;AKAP6;GNB5B;Akap2;AKAP7;AKAP4;GNA13;GNG13B;AKAP12 |
AKAP12B has several biochemical functions, for example, protein kinase A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP12B itself. We selected most functions AKAP12B had, and list some proteins which have the same functions with AKAP12B. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
protein kinase A binding | NBEA;AKAP5;AKAP6;MYRIP;AKAP12B;AKAP13;AKAP12;Akap3;Akap2 |
AKAP12B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP12B here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP12B.
- Q&As
- Reviews
Q&As (9)
Ask a questionThe potential of AKAP12B as a therapeutic target is an active area of research. Modulating the expression or activity of AKAP12B may have implications in cancer treatment and cardiovascular disease. Strategies to target AKAP12B could include gene therapy, small molecule inhibitors, or approaches that aim to modulate its interactions with specific enzymes or signaling molecules. However, more research is needed to fully understand the therapeutic opportunities and challenges associated with targeting AKAP12B.
AKAP12B is a large protein with multiple domains that facilitate its interaction with different molecules. It contains a PSD-95/Discs Large/ZO-1 (PDZ) domain, which is involved in protein-protein interactions. Additionally, AKAP12B has an A-kinase anchor domain that enables its interaction with PKA, as well as other domains, such as an N-terminal acidic region and an actin-binding domain. The specific structure and organization of AKAP12B are still being investigated, and further studies are needed to fully elucidate its structural properties and functional domains.
There have been studies investigating the effects of AKAP12B knockout or knockdown in cellular and animal models. These studies have demonstrated the importance of AKAP12B in cell migration, invasion, and other cellular processes.
The expression and activity of AKAP12B can be regulated at multiple levels. It is subject to transcriptional and post-transcriptional regulation, and its localization and function can be regulated through phosphorylation and protein-protein interactions. Additionally, AKAP12B expression and function may be influenced by various signaling pathways and environmental factors.
Yes, AKAP12B interacts with various protein partners to facilitate specific signaling events. Some notable interaction partners include PKA regulatory subunits, PKC isoforms, protein phosphatases, actin cytoskeleton-associated proteins, and components of the extracellular matrix.
AKAP12B has been implicated in various diseases and conditions. For example, it has been suggested that alterations in AKAP12B expression or function may contribute to cancer progression and metastasis. Reduced expression of AKAP12B has been observed in several cancer types, including breast, prostate, and colon cancer, and has been associated with poor prognosis. Additionally, AKAP12B has been implicated in cardiovascular diseases, such as coronary artery disease and cardiac hypertrophy.
AKAP12B has been implicated in a range of cellular processes, including cell proliferation, migration, and adhesion. It may also play a role in the regulation of gene expression, cytoskeletal dynamics, and neuronal function. Additionally, AKAP12B has been associated with cancer progression and metastasis, suggesting its involvement in tumorigenesis and invasion.
While genetic mutations in AKAP12B have not been extensively studied, certain single nucleotide polymorphisms (SNPs) in the AKAP12 gene have been associated with an increased risk of certain cancers. These SNPs may affect the expression or function of AKAP12B, but further research is needed to fully understand their implications.
AKAP12B is widely expressed in different tissues and organs throughout the body. It is found in the cytoplasm and associated with various cellular compartments, such as the plasma membrane, nucleus, and endoplasmic reticulum.
Customer Reviews (3)
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