Recombinant Zebrafish AKAP12B

• Cat.No.: AKAP12B-5656Z
• Product Overview: Recombinant Zebrafish AKAP12B full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: akap12b A kinase (PRKA) anchor protein 12b [ Danio rerio (zebrafish) ]
• Official Symbol: AKAP12B
• Gene ID: 567365
• mRNA Refseq: NM_001098184
• Protein Refseq: NP_001091654
• UniProt ID: F2Z4T4

Reviews

06/21/2020

Their dedicated team of experts is readily available to address any concerns or difficulties that may arise during my experiments.

09/03/2018

The prompt and efficient assistance provided by the manufacturer significantly enhances my research experience and ensures seamless progress in my work.

12/09/2015

I am grateful to have such a reliable and efficient product that will undoubtedly contribute to the advancement of my scientific endeavors.

Q&As

Can AKAP12B protein be targeted for therapeutic interventions?

The potential of AKAP12B as a therapeutic target is an active area of research. Modulating the expression or activity of AKAP12B may have implications in cancer treatment and cardiovascular disease. Strategies to target AKAP12B could include gene therapy, small molecule inhibitors, or approaches that aim to modulate its interactions with specific enzymes or signaling molecules. However, more research is needed to fully understand the therapeutic opportunities and challenges associated with targeting AKAP12B.

Is there any further information available about the structure and domains of AKAP12B protein?

AKAP12B is a large protein with multiple domains that facilitate its interaction with different molecules. It contains a PSD-95/Discs Large/ZO-1 (PDZ) domain, which is involved in protein-protein interactions. Additionally, AKAP12B has an A-kinase anchor domain that enables its interaction with PKA, as well as other domains, such as an N-terminal acidic region and an actin-binding domain. The specific structure and organization of AKAP12B are still being investigated, and further studies are needed to fully elucidate its structural properties and functional domains.

Are there any known knockout or knockdown studies performed on AKAP12B protein?

There have been studies investigating the effects of AKAP12B knockout or knockdown in cellular and animal models. These studies have demonstrated the importance of AKAP12B in cell migration, invasion, and other cellular processes.

How is AKAP12B protein regulated?

The expression and activity of AKAP12B can be regulated at multiple levels. It is subject to transcriptional and post-transcriptional regulation, and its localization and function can be regulated through phosphorylation and protein-protein interactions. Additionally, AKAP12B expression and function may be influenced by various signaling pathways and environmental factors.

AKAP12B has been implicated in a range of cellular processes, including cell proliferation, migration, and adhesion. It may also play a role in the regulation of gene expression, cytoskeletal dynamics, and neuronal function. Additionally, AKAP12B has been associated with cancer progression and metastasis, suggesting its involvement in tumorigenesis and invasion.

Yes, AKAP12B interacts with various protein partners to facilitate specific signaling events. Some notable interaction partners include PKA regulatory subunits, PKC isoforms, protein phosphatases, actin cytoskeleton-associated proteins, and components of the extracellular matrix.

Can you provide examples of diseases or conditions associated with AKAP12B protein?

AKAP12B has been implicated in various diseases and conditions. For example, it has been suggested that alterations in AKAP12B expression or function may contribute to cancer progression and metastasis. Reduced expression of AKAP12B has been observed in several cancer types, including breast, prostate, and colon cancer, and has been associated with poor prognosis. Additionally, AKAP12B has been implicated in cardiovascular diseases, such as coronary artery disease and cardiac hypertrophy.

What are the potential roles of AKAP12B protein in cellular processes?

AKAP12B has been implicated in a range of cellular processes, including cell proliferation, migration, and adhesion. It may also play a role in the regulation of gene expression, cytoskeletal dynamics, and neuronal function. Additionally, AKAP12B has been associated with cancer progression and metastasis, suggesting its involvement in tumorigenesis and invasion.

Are there any known genetic mutations or polymorphisms associated with AKAP12B protein?

While genetic mutations in AKAP12B have not been extensively studied, certain single nucleotide polymorphisms (SNPs) in the AKAP12 gene have been associated with an increased risk of certain cancers. These SNPs may affect the expression or function of AKAP12B, but further research is needed to fully understand their implications.

Where is AKAP12B protein found in the body?

AKAP12B is widely expressed in different tissues and organs throughout the body. It is found in the cytoplasm and associated with various cellular compartments, such as the plasma membrane, nucleus, and endoplasmic reticulum.