ALMS1
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Official Full Name
Alstrom syndrome 1
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Overview
This gene encodes a protein containing a large tandem-repeat domain. The mouse ortholog of this gene has been shown to function in ciliogenesis in inner medullary collecting duct cells. Mutations in this gene have been associated with Alstrom syndrome. Alternative splice variants have been described but their full length sequences have not been determined. -
Synonyms
ALMS1; Alstrom syndrome 1; Alstrom syndrome protein 1; KIAA0328; ALSS; DKFZp686A118; DKFZp686D1828;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ALMS1-301491H | Recombinant Human ALMS1 protein, GST-tagged | E.coli | GST | Leu2881-His3000 | |
Mouse | ALMS1-1562M | Recombinant Mouse ALMS1 Protein | Mammalian Cell | His | ||
Mouse | ALMS1-480M-B | Recombinant Mouse ALMS1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ALMS1-480M | Recombinant Mouse ALMS1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
ALMS1 involved in several pathways and played different roles in them. We selected most pathways ALMS1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALMS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ALMS1 has several biochemical functions, for example, alpha-actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALMS1 itself. We selected most functions ALMS1 had, and list some proteins which have the same functions with ALMS1. You can find most of the proteins on our site.
Function | Related Protein |
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alpha-actinin binding | KCNN2;DAG1;ADORA2A;MYOT;MAGI1;LRRC10;ALMS1;RARA;PKD2L1 |
ALMS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALMS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALMS1.
Atp6v1a
- Q&As
- Reviews
Q&As (14)
Ask a questionThe ALMS1 gene is expressed in several tissues and organs, including the retina, cerebral cortex, small intestine, kidney, and pancreas.
Alstrom syndrome is an autosomal recessive disorder caused by a mutation in the ALMS1 gene.
No studies have shown that ALMS1 mutations are associated with cancer.
Mutations in the ALMS1 gene may lead to changes in the structure or function of the ALMS1 protein, which may affect its role in the cell as well as the metabolism and signaling processes of the entire cell.
There are treatments that address the symptoms of Alstrom syndrome, including vision rehabilitation training, diabetes treatment, and hearing tests.
The ALMS1 gene encodes the ALMS1 protein, the function of which is not fully understood.
Yes, some research suggests that the ALMS1 gene may also have a role in nervous system development.
Yes, there is a great diversity of ALMS1 mutations.
There are few studies on the relationship between ALMS1 gene mutation and congenital heart disease, and there is no clear conclusion at present.
Some studies suggest that ALMS1 gene mutations may be associated with autoimmune diseases, rheumatoid arthritis, etc.
Mutations in the ALMS1 gene may affect intellectual development, but the extent of the effect is less certain.
There is currently no gene therapy for the ALMS1 gene mutation.
Mutations in the ALMS1 gene can cause Alstrom syndrome, which has symptoms including early blindness, obesity, diabetes, deafness and more.
Yes, because Alstrom syndrome is an autosomal recessive disorder, the ALMS1 gene mutation may be passed on to the next generation.
Customer Reviews (4)
Write a reviewGood stability under different temperature and humidity conditions.
The effect of chemical modification, such as PEGylation or glycosylation, is small.
Accurate localization and function in cells.
ALMS1 was effective in removing impurities during purification.
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