Gpt
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Official Full Name
glutamic-pyruvate transaminase (alanine aminotransferase)
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Overview
This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase. -
Synonyms
GPT; glutamic-pyruvate transaminase (alanine aminotransferase); alanine aminotransferase 1; ALT1; GPT1; AAT1; Alanine aminotransferase; ALAT1_HUMAN; Glutamate pyruvate transaminase 1; Glutamic alanine transaminase 1; Glutamic pyruvic transaminase 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1; GPT 1; OTTHUMP00000228783; glutamic-alanine transaminase 1;
- Recombinant Proteins
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Human
- Mouse
- Pig
- Porcine
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Human
- Human Heart
- Human Liver
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Porcine Heart
- Wheat Germ
- Yeast
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Gpt Related Articles
Gpt involved in several pathways and played different roles in them. We selected most pathways Gpt participated on our site, such as Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gpt were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Arginine biosynthesis | ARG1;GLUD1A;GLS;GLUD1;GPT2L;NOS2A;ASL2;OTC;NOS2 |
Alanine, aspartate and glutamate metabolism | GLUL;ADSL;NIT2;ABAT;ADSSL;CPS1;GOT2B;GLS2;GFPT2 |
Metabolic pathways | CBR1;PLCD1;GLCE;PNLIPRP3;ACOX3;AGL;GPAT2;ALOX12;COX5B2 |
Carbon metabolism | HIBCH;TPI1;PKMB;GLDC;GPIA;FBP1B;IDH3G;SUCLG2;PKMA |
-Oxocarboxylic acid metabolism | ACO2;GOT2;IDH3A;BCAT1;GOT2B;GOT1;GPT;IDH2;BCAT2 |
Biosynthesis of amino acids | ASS1;ALDOCB;PGAM2;RPE;PSPH;TPI1B;PKMB;IDH3B;PKM2 |
Gpt has several biochemical functions, for example, L-alanine:2-oxoglutarate aminotransferase activity, pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gpt itself. We selected most functions Gpt had, and list some proteins which have the same functions with Gpt. You can find most of the proteins on our site.
Function | Related Protein |
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L-alanine:2-oxoglutarate aminotransferase activity | GPT2L;GPT;GPT2 |
pyridoxal phosphate binding | PHYKPL;MARC1;MOSC2;MARC2;GCAT;DDC;ALAS1;GPT;CCBL2 |
Gpt has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gpt here. Most of them are supplied by our site. Hope this information will be useful for your research of Gpt.
CDC7; RALA; SASS6
- Q&As
- Reviews
Q&As (5)
Ask a questionThe GPT gene, encompassing GPT1 and GPT2, is pivotal in glucose and amino acid metabolism. GPT2 is notably linked to tumorigenesis in various cancers, while the involvement of GPT1 in cancer remains uncertain and requires further exploration.
The GPT gene encodes ALT1, a key enzyme in cellular metabolism. ALT1 facilitates the reversible transamination between alanine and 2-oxoglutarate, crucial for glucose and amino acid metabolism. Elevated serum ALT1 levels are commonly used as a biomarker for liver injury caused by drug toxicity, infection, alcohol, and steatosis.
SMS protein alone doesn't impact LSCC patient prognosis, but when combined with GPT, it shows significance. Inconsistency between SMS transcriptional and protein levels may stem from various factors, including the involvement of regulatory elements and different post-transcriptional and post-translational modifications.
Analysis of LSCC tissues and cell lines revealed an inverse relationship between GPT and SMS expressions, confirmed through qRT-PCR and TCGA data. GPT protein, primarily located in the epithelium, was down-regulated in LSCC tissues.
GPT gene expression serves as a marker for cancer-induced metabolic reprogramming in tissues, indicating shifts in energy metabolism and biosynthetic processes.
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