ANG
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Official Full Name
Angiogenin
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Overview
Angiogenin (Ang) also known as ribonuclease 5 is a protein that in humans is encoded by the ANG gene. Angiogenin is a potent stimulator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Hooper et al. (2003) reviewed the evidence that angiogenins are involved in host defense and noted that inflammation provokes upregulated ANG mRNA expression in liver and an increase in detectable ANG protein in serum. Weremowicz et al. (1989, 1990) assigned the human angiogenin gene to chromosome 14q11. -
Synonyms
Angiogenin; Ang; ribonuclease 5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Human
- Mouse
- Pig
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- E.coli
- E.Coli or Yeast
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- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- ANG Related Articles
- ANG Related Research Area
ANG involved in several pathways and played different roles in them. We selected most pathways ANG participated on our site, such as Adherens junctions interactions, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adherens junctions interactions | CDH18;CDH17;CADM2A;CADM2;CDH12A;CDH5;CDH4;CDH12;CTNNA1 |
Cell junction organization | JUPA;CDH10A;CDH12A;COL17A1A;DST;COL17A1;PLECA;CDH4;TESK1 |
Cell-Cell communication | CADM2A;CDH6;KIRRELA;PLEC;CDH2;CDH5;CLDN20;F11R.2;CDH18 |
Cell-cell junction organization | CDH12A;CDH6;CDH17;JUP;CDH11;ANG;CDH13;CDH10;F11R.2 |
ANG has several biochemical functions, for example, DNA binding, actin binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANG itself. We selected most functions ANG had, and list some proteins which have the same functions with ANG. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ARNTL2;ZNF625;SSRP1;SIX6B;CREB1B;AIFM1;PMS2;LASS5;ALX4 |
actin binding | WHAMM;MYLK;MSN;CNN1A;CAPZB;MYO1F;DIAP3;KCNMA1;WASF1 |
copper ion binding | METTL17;MOXD2;LOXL4;APOA4;HEPHL1;TYRP1;LOXL3;MT1;S100A5 |
endonuclease activity | NTHL1;MRE11A;ENDOU2;EAR2;G3BP1;RNASEL4;EAR4;OGG1;RNASEL3 |
heparin binding | PCOLCE2;LAMC2;CTGFA;RSPO4;TENM1;HRG;APP;MPO;FGF12 |
peptide binding | NPFFR2.1;OXTRL;NPFFR1L1;Ctsl;GNRHR4;CSNK1D;ERAP2;GNRHR1;HCRTR1 |
protein binding | DHDDS;ZNF436;KCNG4;CDC42BPA;XIRP2;BMP1A;KRTAP12-1;EZR;CTNNBL1 |
protein homodimerization activity | XPNPEP1;CTBP2;LRRFIP1;ENPP1;FOXP3;ERP29;CBS;AOC3;KLHL7 |
rRNA binding | RPL12;PPAN;MTERFD2;RNASEL;EMG1;RPS4X;MRPS7;RPS5;FASTKD2 |
receptor binding | AMN;EDN3;ENSA;GLA;RSPO1;HLA-F;NRG1;GNPAT;FASLG |
ribonuclease activity | EAR14;RNASET2;ERN2;RNASEL2;RNASET2B;ANG4;RNASE2;ANG;DIS3L2 |
ANG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANG here. Most of them are supplied by our site. Hope this information will be useful for your research of ANG.
ACTN2; FST; RNH1; TDGF1; FST; PTEN; ATP6AP1; ABCG8
- Q&As
- Reviews
Q&As (20)
Ask a questionGiven its involvement in angiogenesis and disease processes, ANG protein has been explored as a therapeutic target. However, more research is needed to fully understand its complex biology and potential for targeted therapies.
ANG protein levels have been measured in various cancer types and have shown prognostic value in some cases. High levels of ANG protein have been associated with poor prognosis in certain cancers, indicating its potential as a prognostic biomarker.
In neurodegenerative disorders, ANG protein is thought to have multiple functions. It has been shown to promote the survival of neurons and protect them from various kinds of stress. ANG protein also possesses ribonucleolytic activity, where it can cleave RNA molecules, and this activity may be important for its neuroprotective effects.
Yes, ANG protein has been implicated in various cellular processes beyond angiogenesis. It has been found to play a role in cell survival, proliferation, migration, and RNA metabolism. ANG protein can also promote the growth of neurons and participate in synaptic plasticity.
Yes, several mutations in the ANG gene have been identified in individuals with neurodegenerative disorders such as ALS. These mutations can impair ANG protein function, leading to the development of the disease.
ANG protein levels can be measured in clinical settings through various laboratory techniques, including enzyme-linked immunosorbent assays (ELISAs) or immunohistochemistry. However, the clinical utility of measuring ANG protein levels for assessing disease progression or treatment response remains to be fully established and is currently limited to specific research settings. Further studies are needed to determine its potential as a diagnostic or prognostic biomarker.
Yes, there is evidence to suggest a relationship between ANG protein and inflammation. Inflammatory signals can induce the expression of ANG protein, and elevated ANG protein levels have been detected in inflamed tissues. ANG protein has also been shown to interact with components of the immune system and modulate immune responses in certain contexts.
ANG protein is found both intracellularly and extracellularly. It is present in various tissues, including endothelial cells, neurons, and certain cancer cells.
There are currently no FDA-approved drugs specifically targeting ANG protein. However, some preclinical studies have explored the use of ANG inhibitors or activators in different disease models, including cancer. Clinical trials investigating the therapeutic potential of ANG protein-targeted therapies are limited but may emerge in the future.
ANG protein has been implicated in cardiovascular health and disease. It is involved in processes such as endothelial cell migration and vascular development. ANG protein has also been associated with conditions like atherosclerosis and ischemic heart disease, although further research is needed to fully understand its role in cardiovascular health and its potential as a therapeutic target.
ANG protein has been investigated as a potential therapeutic target for neurodegenerative diseases, including ALS. However, developing effective therapies targeting ANG protein is challenging due to its involvement in various cellular processes and the need to specifically modulate its functions without causing detrimental side effects. Further research is needed to better understand the role of ANG protein in disease pathogenesis and identify potential therapeutic strategies.
ANG protein has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions. In cancer, ANG protein can promote tumor growth and metastasis by inducing angiogenesis. In neurodegenerative disorders, ANG protein dysfunction has been linked to diseases like ALS (amyotrophic lateral sclerosis).
ANG protein levels have been measured in various disease states and can serve as a biomarker for certain conditions. For example, elevated ANG protein levels have been associated with certain cancers, making it potentially useful in diagnostic testing or monitoring disease progression.
Yes, there are natural regulators and inhibitors of ANG protein activity. One example is the ribonuclease inhibitor protein, which can bind to ANG protein and inhibit its ribonucleolytic activity. Additionally, certain microRNAs have been found to regulate ANG protein expression levels.
Yes, several small molecules and antibodies have been developed as inhibitors or activators of ANG protein. These molecules can be used for research purposes or potentially as therapeutic agents in treating diseases involving ANG protein dysregulation.
While ANG protein has been primarily studied in relation to ALS, there is evidence to suggest its potential involvement in other neurological disorders. For example, altered ANG protein levels and genetic variations in the ANG gene have been associated with conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. However, more research is needed to fully elucidate the role of ANG protein in these disorders.
ANG protein has been linked to ALS, a neurodegenerative disorder, through genetic mutations. Certain mutations in the ANG gene can lead to a decrease in ANG protein production or impair its function. This can contribute to the development of ALS, as ANG protein is involved in various processes that are important for maintaining the health and function of motor neurons.
ANG protein has been considered as a potential target for anti-angiogenic therapies. Inhibiting ANG protein's angiogenic activity could help in limiting pathological angiogenesis in diseases such as cancer. However, developing effective ANG inhibitors that specifically target pathological angiogenesis while sparing physiological angiogenesis remains a challenge.
Yes, various animal models have been used to study ANG protein and its role in diseases. For example, mice models with genetically modified ANG genes have been created to mimic certain mutations associated with neurodegenerative disorders like ALS. These models allow researchers to investigate the impact of ANG protein dysfunction on disease development and progression.
The expression and activity of ANG protein are regulated by various factors such as growth factors, cytokines, and cellular stress. Specific signaling pathways involving proteins like VEGF, HIF-1α, and PI3K/AKT are known to influence ANG protein regulation.
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