ACOX1
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Official Full Name
acyl-CoA oxidase 1, palmitoyl
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Overview
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
ACOX1; acyl-CoA oxidase 1, palmitoyl; acyl Coenzyme A oxidase 1, palmitoyl; peroxisomal acyl-coenzyme A oxidase 1; PALMCOX; ACOX1_HUMAN; AOX; EC 1.3.3.6; Palmitoyl CoA oxidase; Palmitoyl-CoA oxidase; Peroxisomal acyl coenzyme A oxidase 1; SCOX; Straight chain acyl CoA oxidase; Straight-chain acyl-CoA oxidase; acyl-CoA oxidase, straight-chain; peroxisomal fatty acyl-CoA oxidase; acyl-Coenzyme A oxidase 1, palmitoyl; ACOX;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- His|GST
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
ACOX1 involved in several pathways and played different roles in them. We selected most pathways ACOX1 participated on our site, such as Fatty acid degradation, alpha-Linolenic acid metabolism, Biosynthesis of unsaturated fatty acids, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Fatty acid degradation | HADHB;GCDHA;ALDH2.2;ACADL;ACSL1B;HADH;ALDH9A1B;ADH1C;HADHA |
alpha-Linolenic acid metabolism | PLA2G4F;PLA2G2E;ACAA1;ACOX1;PLA2G2A;PLA2G4D;PLA2G10;PLA2G6;PLA2G4C |
Biosynthesis of unsaturated fatty acids | HADHA;HSD17B12A;PTPLA;BAAT;ACOT7;PTPLAD1;ACOT5;HSD17B12B;PECR |
Metabolic pathways | SLC33A1;DGAT2;NAMPT;PLA2G7;CHIA.2;NDST2;P4HA1;IDH3A;ASAH1 |
Fatty acid metabolism | HADH;ACADL;MCAT;ELOVL5;ACSL4;ACAT2;HADHAB;ACADS;HADHA |
PPAR signaling pathway | PPARAB;PPARDB;ACSL5;ACSBG1;DBI;RXRGB;SLC27A1B;ACAA1;APOC3 |
cAMP signaling pathway | AMH;PTGER3;CREB3L3;PTCH1;PDE4B;PIK3R5;GRIA2;NFKBIA;RYR2 |
Peroxisome | ABCD1;XDH;MLYCD;DAO.2;DHRS4;ACAA1A;GNPAT;ABCD3;ECH1 |
ACOX1 has several biochemical functions, for example, FAD binding, PDZ domain binding, acyl-CoA dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOX1 itself. We selected most functions ACOX1 had, and list some proteins which have the same functions with ACOX1. You can find most of the proteins on our site.
Function | Related Protein |
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FAD binding | CRY2;DAO.3;CYB5R3;KMO;DAO1;DAO.1;DAO.2;MICAL1;AGPS |
PDZ domain binding | GJA1;PLEKHA2;CLCN3;EXOC4;LPAR1;PDZK1;GRIA1;CFTR;ATP2B1B |
acyl-CoA dehydrogenase activity | ACADVL;ACAD8;ACAD9;ACOXL;GCDHB;ACADSB;ACADM;ACADS;ACADL |
acyl-CoA oxidase activity | ACOXL;ACOX2;ACOX1 |
electron carrier activity | ACADL;AKR1A1;CYP1A2;NDUFA12;FDX1L;SRD5A1;COX11;NCF1;NOX4 |
fatty-acyl-CoA binding | ACAD9;HADHA;ACOT7;GCDHB;ACADVL;ECI2;IVD;GCDHA;ACOXL |
flavin adenine dinucleotide binding | DLDH;ACAD9;ACAD8;GCDHA;GULO;FMO5;AOX3L1;CYB5R3;ACOX2 |
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | ETFA;ACOXL;ACAD9;IVD;GCDH;ACOX3;ACADM;ACADL;ACAD11 |
palmitoyl-CoA oxidase activity | ACAA1;ACAA1A;ACOXL;ACOX1;ACADL |
protein N-terminus binding | NCOA1;KCNQ2;EXOC4;MEN1;RASSF1;UNC13A;ARF6;GTF2H3;ERCC2 |
receptor binding | NPFFL;FZD1;PICK1;GNPAT;FZD8;GFRA1;APP;WNT5B;CAV1 |
ACOX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOX1.
UBA1; UBE2N; UBE2V1; midostaurin; TYSND1; PEX5; GABARAPL1; PEX14
- Q&As
- Reviews
Q&As (13)
Ask a questionACOX1 has potential therapeutic applications in treating metabolic disorders, such as diabetes, obesity, and fatty liver disease. By enhancing ACOX1 activity or expression, it may be possible to increase fatty acid β-oxidation and reduce the accumulation of lipids in tissues. Additionally, modulating ACOX1 expression or activity may also have implications for cancer therapy, as ACOX1 has been shown to play a role in the proliferation and survival of certain cancer cells.
ACOX1 expression is highest in tissues that have high rates of β-oxidation, such as liver, kidney, and heart. However, it is also expressed in other tissues, such as muscle, adipose tissue, and brain, albeit at lower levels. The expression of ACOX1 can also be regulated by various factors, such as nutrient status and hormonal signaling.
There are currently no drugs or compounds approved by the FDA that specifically target ACOX1 for therapeutic purposes. However, some studies have identified potential compounds that could modulate ACOX1 activity, such as perhexiline and bezafibrate. These compounds have been shown to increase fatty acid oxidation and reduce lipid accumulation in animal models, and further research is needed to determine their potential efficacy in human patients.
Yes, mutations in the ACOX1 gene have been associated with various peroxisomal disorders, such as X-linked adrenoleukodystrophy (ALD) and Refsum disease. These mutations can impair the function of ACOX1 and lead to a buildup of long-chain fatty acids, which can cause neurological, liver, and other health problems.
ACOX1 may have applications in food production and agriculture for improving the quality and nutritional content of crops. For example, increasing ACOX1 expression may lead to increased levels of unsaturated fatty acids in plant oils, which are considered to be healthier for human consumption than saturated fatty acids. Additionally, ACOX1 may play a role in the biosynthesis of plant hormones, such as jasmonates, which can affect plant growth and response to stress.
There may be ethical concerns related to the use of genetic engineering techniques to modify ACOX1 expression and other metabolic pathways in crops. Some people may view the use of genetic engineering as potentially harmful to the environment, and there may be questions about the safety and long-term effects of consuming crops that have been genetically modified. Additionally, there may be questions about the potential impact of these modifications on biodiversity and sustainable agriculture.
Some studies have suggested that ACOX1 may play a role in the progression and metastasis of certain types of cancer. For example, decreased expression of ACOX1 has been associated with poor prognosis in colorectal cancer and breast cancer. However, the mechanisms underlying these effects are not fully understood and more research is needed to determine the exact role of ACOX1 in cancer biology.
ACOX1 levels and activity may serve as a biomarker for certain diseases or conditions, such as non-alcoholic fatty liver disease (NAFLD) and diabetic neuropathy. In patients with NAFLD, ACOX1 activity has been shown to be reduced, indicating a potential role for ACOX1 in the pathogenesis of this condition. Similarly, ACOX1 expression has been linked to the development and progression of diabetic neuropathy, suggesting that it could serve as a marker for this complication in diabetic patients.
Understanding the role of ACOX1 in fatty acid metabolism and its dysregulation in metabolic disorders could lead to the development of new therapies that target this pathway. For example, identifying compounds that selectively inhibit or activate ACOX1 could have therapeutic potential for treating peroxisomal disorders, while targeting downstream enzymes in the β-oxidation pathway may be beneficial in other conditions such as fatty liver disease.
Yes, ACOX1 expression has been shown to be altered in various metabolic disorders, such as type 2 diabetes and non-alcoholic fatty liver disease. Therefore, ACOX1 could potentially be used as a biomarker for these conditions, although further research is needed to validate its diagnostic and prognostic utility.
Yes, ACOX1 is part of a larger complex of peroxisomal enzymes and proteins involved in fatty acid β-oxidation. Other enzymes in this pathway include acyl-CoA synthetase, which activates fatty acids by adding coenzyme A, and several enzymes that catalyze the cleavage of long-chain fatty acids into two-carbon fragments. Additionally, the proteins PEX5 and PEX7 are required for the import of fatty acyl-CoAs into peroxisomes, where ACOX1 and other enzymes in the pathway are located.
ACOX1 inhibition has been suggested as a possible therapeutic strategy for the treatment of certain disorders characterized by defective peroxisomal β-oxidation, such as X-linked adrenoleukodystrophy (ALD). Activating ACOX1 could also be beneficial in conditions where increased β-oxidation is desired, such as in situations of high-energy demand. However, more research is needed to determine the feasibility and safety of manipulating ACOX1 activity in clinical settings.
There are currently no drugs or compounds approved for therapeutic use that directly target ACOX1. However, some compounds have been identified that can modulate ACOX1 activity, such as the peroxisome proliferator-activated receptor (PPAR) agonist fenofibrate, which has been shown to increase ACOX1 expression and activity.
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