ARHGEF18A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Zebrafish | ARHGEF18A-12827Z | Recombinant Zebrafish ARHGEF18A | Mammalian Cell | His |
|
- Involved Pathway
- Protein Function
- Interacting Protein
ARHGEF18A involved in several pathways and played different roles in them. We selected most pathways ARHGEF18A participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF18A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell death signalling via NRAGE, NRIF and NADE | AKAP13;ECT2;FGD2;FGD4;NET1;CASP2;KALRNB;ARHGEF18;OBSCN |
| G alpha (12/13) signalling events | ADRA1B;DCLRE1B;GNA13B;ITSN1;ARHGEF3;FGD2;ARHGEF18;KALRNB;ECT2 |
| GPCR downstream signaling | CHRM4;SOUL3;CNR1;TRIO;OPN4B;APPB;FGD4A;CHRM1;RXFP2B |
| NRAGE signals death through JNK | ARHGEF3;FGD2;PLEKHG2;MCF2L;ARHGEF1A;ARHGEF18;ABR;ARHGEF18A;DCLRE1B |
| Rho GTPase cycle | TAGAP1;ARHGAP18;ARHGAP24;ABR;OPHN1;NET1;ARHGEF18A;MYO9B;RHOU |
| Signal Transduction | ARHGAP23;PENKA;CCL35.2;C;GPR55;TULP3;NPSR1;RNF146;APLNR |
| Signaling by GPCR | ARHGAP4A;RGS6;TAS2R16;GPR132B;RCA2.1;ARHGEF17;RGS20;OR52B4;RGS1 |
| Signaling by Rho GTPases | ARHGAP4A;STARD13;TAX1BP3;NF2A;RHOJ;NOXO1A;ARHGEF17;ARHGAP17B;ARHGAP20 |
ARHGEF18A has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF18A itself. We selected most functions ARHGEF18A had, and list some proteins which have the same functions with ARHGEF18A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rho guanyl-nucleotide exchange factor activity | PLEKHG6;DOCK9;ARHGEF18;DNMBP;ARHGEF33;ARHGEF19;FGD2;ARHGEF7A;ARHGEF15 |
ARHGEF18A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF18A here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF18A.
- Q&As
- Reviews
Q&As (6)
Ask a questionAs of now, there are no known therapeutic interventions directly targeting ARHGEF18A. However, if its involvement in specific diseases or conditions is further elucidated, it might become a potential target for therapeutic development in the future.
Due to limited research on ARHGEF18A, there are no specific animal models designed to study its function. However, animal models with genetic modifications in the ARHGEF18A gene could be generated to better understand its role in various biological processes.
While ARHGEF18A is not as extensively linked to neurodevelopmental disorders as its variant counterpart ARHGEF18, further research is needed to determine its specific involvement in conditions like autism spectrum disorder or intellectual disability.
Yes, ARHGEF18A can interact with various proteins to mediate its functions. These interactions may involve binding to other guanine nucleotide exchange factors, Rho GTPases, or proteins involved in cytoskeletal dynamics, cell signaling, or other cellular processes.
Currently, there is limited information available regarding disease-associated mutations in the ARHGEF18A gene. Further studies and genetic analyses are necessary to determine if any mutations in ARHGEF18A are linked to specific disorders or conditions.
The expression of ARHGEF18A might be cell-type specific, with varying levels in different tissues and cell types. Further studies are needed to determine its expression pattern across various cell types and tissues.
Customer Reviews (8)
Write a reviewIt can be seamlessly integrated into various molecular biology techniques, such as immunoassays, cell-based functional assays, and protein-protein interaction studies.
Its adaptability enables researchers to unravel the complex interplay and functional relevance of ARHGEF18A in different biological processes.
They can offer insights into interpreting results and assist in identifying trends or patterns that may be relevant to the specific research question.
the manufacturer's technical support is instrumental in assisting researchers throughout their trials.
The prompt and precise support provided by the manufacturer ensures that researchers can proceed with their work smoothly, without any hindrances or uncertainties.
They can provide valuable guidance in experimental design, optimization, and troubleshooting, helping researchers overcome challenges and maximize the efficiency of their trials.
The manufacturer's technical support can also aid researchers in the data analysis phase.
As a researcher utilizing the ARHGEF18A protein in my trials, I have been highly impressed with its numerous advantages that significantly contribute to the success of my experimental endeavors.
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