ARHGEF28
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Official Full Name
Rho guanine nucleotide exchange factor (GEF) 28
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Overview
This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants. -
Synonyms
ARHGEF28; RIP2; RGNEF; p190RHOGEF; Rho guanine nucleotide exchange factor (GEF) 28; rho guanine nucleotide exchange factor 28; p190-RhoGEF; Rho interacting protein 2; rho-guanine nucleotide exchange factor; 190 kDa guanine nucleotide exchange factor;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ARHGEF28-540HCL | Recombinant Human ARHGEF28 lysate | HEK293 | N/A |
- Involved Pathway
- Protein Function
- Interacting Protein
ARHGEF28 involved in several pathways and played different roles in them. We selected most pathways ARHGEF28 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Axon guidance | RAC3;GPC1A;PAK2;EPHA4;KLB;COL9A1;NRP1;RHOGA;CXCR4 |
Developmental Biology | LGI1A;CEBPB;NR5A1;ACTR2;DPYSL5B;SEMA3AB;CFC1;MED31;MEF2B |
EPH-Ephrin signaling | EPHB3A;ARPC3;MYL9;ARPC2;EPHA2;ARPC1A;EPHA2A;EPHB4A;AP2M1 |
EPHB-mediated forward signaling | ITSN1;KALRN;EPHB4A;ARPC3;CFL1;ACTR2B;EPHB3A;KALRNB;ACTR2 |
Regulation of RhoA activity | ARHGEF10;DEF6;PLEKHG6;MYO9B;DLC1;ARHGAP4;ARHGEF3;ARHGEF15;ARHGEF25 |
Signaling events mediated by focal adhesion kinase | ACTA1;ARHGEF28;KLF8;BMX;ARHGAP26 |
ARHGEF28 has several biochemical functions, for example, RNA binding, Rho guanyl-nucleotide exchange factor activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF28 itself. We selected most functions ARHGEF28 had, and list some proteins which have the same functions with ARHGEF28. You can find most of the proteins on our site.
Function | Related Protein |
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RNA binding | MRPL12;PRPF40B;RPL27A;MCTS2;CSTF2;PAPOLA;HNRPKL;SNRPF;EIF4B |
Rho guanyl-nucleotide exchange factor activity | ITSN2;TIAM2;ARHGEF25;ECT2;PLEKHG6;QUO;FGD4A;PLEKHG5;ARHGEF2 |
metal ion binding | HBBE2;IKZF2;ZIC5;B4GALT4;TDO2B;YME1L1;NCS1A;KIN;LNPA |
ARHGEF28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF28 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF28.
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- Q&As
- Reviews
Q&As (11)
Ask a questionLimited information is available regarding the subcellular localization of ARHGEF28. It is suggested to be mainly localized in the cytoplasm, but further studies are needed to confirm and elucidate its precise subcellular localization.
The involvement of ARHGEF28 in developmental processes has not been extensively studied. Future research may shed light on its potential role during development.
Studies on the tissue distribution of ARHGEF28 are scarce. Further investigations are required to determine its expression pattern across various tissues.
The protein interactors of ARHGEF28 have not been extensively studied. More research is needed to identify its potential interaction partners and elucidate its molecular mechanisms.
ARHGEF28 has not been extensively investigated in animal models or in vivo studies. Further research is required to explore its roles and functions in various animal models and physiological contexts.
There are currently no widely established functional assays or experimental approaches specific to studying ARHGEF28. Researchers may employ a variety of techniques, such as knockdown or overexpression experiments, to assess its potential functions or roles in specific cellular processes.
The specific physiological processes and cellular functions associated with ARHGEF28 are unknown. Further investigations are required to determine its involvement in various biological contexts.
The existence of alternative splicing isoforms for ARHGEF28 has not been reported in current literature. However, future research may uncover the presence of alternative variants and their potential functional implications.
There is currently limited information about the involvement of ARHGEF28 in neuronal development or neurodegenerative diseases. Future investigations may reveal its potential roles in these contexts.
Limited studies have investigated ARHGEF28 in non-human organisms. For example, one study in mice demonstrated its expression in the brain and its potential involvement in regulating dendritic spine morphology. Further research in non-human organisms may provide additional insights into the function of ARHGEF28.
There are no known diseases or conditions specifically associated with ARHGEF28 dysregulation at present. However, with additional studies, potential links to certain diseases or conditions may be discovered.
Customer Reviews (8)
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